A Case of CD56<sup>+</sup> Mycosis Fungoides

Klekotka, Paul; Faulkner-Jones, Beverly E.; Heffernan, Michael

doi:10.1001/archderm.142.10.1370

Cited by 13 publications

(4 citation statements)

References 3 publications

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“…17 Expression of CD56 has been documented only in sporadic case reports. [18][19][20][21][22][23][24][25] Interestingly, also on the molecular level, variability in TCRg gene rearrangement has been described in concurrent biopsies of MF from the same patient. 26 Our findings suggest that in a single patient, there may be substantial phenotypic variation between lesions of MF present at the same time.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic Variation in Different Lesions of Mycosis Fungoides Biopsied Within a Short Period of Time From the Same Patient

Kash

Massone

Fink‐Puches

et al. 2016

The American Journal of Dermatopathology

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Phenotypic variants of mycosis fungoides (MF) include mainly the expression of cytotoxic markers by neoplastic cells (either α/β or γ/δ cytotoxic). To manage the patient properly, distinction from other cutaneous cytotoxic natural killer/T-cell lymphomas is paramount. Particularly for cutaneous γ/δ T-cell lymphoma, distinction is often based on clinicopathologic correlation (presence of tumors at first diagnosis as opposed to patches only in MF). The authors report a case of cytotoxic MF characterized by expression of TCRγ in two of three biopsies performed within a time frame of 1 week. The patient presented with patches, plaques, and 1 tumor at the time of first diagnosis; thus, distinction from cutaneous γ/δ T-cell lymphoma was not possible on clinical grounds alone. The diagnosis of MF was established, thanks to the phenotypic variations revealed by the three biopsies, with 1 lacking expression of cytotoxic proteins (TIA-1 and granzyme B) and of TCRγ. This case shows the importance to perform several biopsies in cases of cutaneous lymphoma, as morphologic and phenotypic features are variable and information gathered from a single biopsy may result in a wrong diagnosis.

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Section: Discussionmentioning

confidence: 99%

Phenotypic Variation in Different Lesions of Mycosis Fungoides Biopsied Within a Short Period of Time From the Same Patient

Kash

Massone

Fink‐Puches

et al. 2016

The American Journal of Dermatopathology

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“…45,58 Other immunophenotypic variants of MF, including CD8+/CD42, CD4+/CD56+/CD82, CD56+/CD42/CD82, and CD8+/ CD56+/CD42 cases, have also been described. [58][59][60][61][62][63][64][65][66][67][68] Although most MF cases are thought to arise from the CD4+/CD82 T-helper memory subset, 2 it is unclear whether MF variants that …”

Section: Discussionmentioning

confidence: 99%

Flow Cytometric Evaluation of Skin Biopsies for Mycosis Fungoides

Jokinen

Fromm

Argényi

et al. 2011

The American Journal of Dermatopathology

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Multicolor flow cytometry (FC) is indispensable for lymphoma diagnosis and classification, but its utility in evaluating skin biopsies for mycosis fungoides (MF) is not well established. We describe the largest series to date of skin biopsies evaluated by FC for MF (n = 33), and we compare the flow cytometric results with the histologic, molecular, and clinical findings. Abnormal T-cell populations were identified by FC in 14 of 18 patients (78%) having histologically confirmed MF and in no patient whose histology was negative or indeterminate for MF (n = 14). One patient had histologic, flow cytometric, and molecular findings compatible with MF, but this patient's clinical course was more suggestive of a drug eruption. Fourteen of 15 abnormal T-cell populations showed definitive aberrant expression of at least 2 surface antigens, including CD2 (47%), CD3 (67%), CD4, CD5 (87%), CD7, and CD45 (67%); most cases (67%) had light scatter properties suggesting increased cell size and/or cytoplasmic complexity. The high specificity of FC suggests that it will be a useful adjunct to routine histology in the evaluation of diagnostic skin biopsies for MF.

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“…41 There are a total of 7 patients with MF manifesting a CD56 phenotype previously reported in the literature. [42][43][44][45] Only one of these cases exhibited a CD4 phenotype. The other cases were of the null phenotype (4) or were CD8 1 (2).…”

Section: Discussionmentioning

confidence: 99%