A Case of Capecitabine-induced Hyperpigmentation and Radiation Recall Phenomenon

Ghosal, Niladri; Misra, Vatsala

doi:10.1016/j.clon.2009.02.007

“…More recently, Ghosal and Misra have reported a case 5 with thoracic hyperpigmentation instead of inflammation being the main clinical finding. Other well known capecitabine side effects are hyperpigmentation associated with palmar-plantar erythrodisesthesia 6 or even Stevens-Johnson syndrome 7 .…”

Section: Discussionmentioning

confidence: 99%

Case Report: Capecitabine-induced radiation recall phenomenon: a case report

Aguilar

¹

,

Ramírez

²

,

García-Garré

³

2013

F1000Res

6

0

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Radiation recall dermatitis is defined as an inflammatory reaction of the skin at the site of previous irradiation. Different drugs have been associated with triggering this phenomenon, and it can also affect other areas and organs where previous radiotherapy has been administered. The time gap between the inflammatory reaction and previous radiation can range from days to several years. We report a case of capecitabine-induced Radiation Therapy Oncology Group (RTOG) grade 4 (ulcerating dermatitis) recall skin toxicity of skin irradiated 3 years previously. To our knowledge, this is the first reported case of capecitabine-induced RTOG grade 4 (ulcerating dermatitis) recall skin toxicity of previously irradiated skin. Clinicians should be aware of this phenomenon, even when considering patients for whom it has been a long time since previous radiation therapy. This unusual and late drug side effect should be borne in mind in the differential diagnosis and management of advanced-disease patients as it may be confused with local relapse or infectious complication of previously operated areas.

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“…More recently, Ghosal and Misra have reported a case 5 with thoracic hyperpigmentation instead of inflammation being the main clinical finding. Other rare though well known Capecitabine side effects are hyperpigmentation associated with palmar-plantar erythrodisesthesia 6 or even Stevens-Johnson syndrome 7 .…”

Section: Discussionmentioning

confidence: 99%

Capecitabine-induced radiation recall phenomenon: a case report

Aguilar

¹

,

Ramírez

²

,

García-Garré

³

2012

View full text Add to dashboard Cite

Radiation recall dermatitis is defined as an inflammatory reaction of the skin at the site of previous irradiation. Different drugs have been associated with triggering this phenomenon, and it can also affect other areas and organs where previous radiotherapy has been administered. The time gap between the inflammatory reaction and previous radiation can range from days to several years. We report a case of capecitabine-induced Radiation Therapy Oncology Group (RTOG) grade 4 (ulcerating dermatitis) recall skin toxicity of skin irradiated 3 years previously. To our knowledge, this is the first reported case of capecitabine-induced RTOG grade 4 (ulcerating dermatitis) recall skin toxicity of previously irradiated skin. Clinicians should be aware of this phenomenon, even when considering patients for whom it has been a long time since previous radiation therapy. This unusual and late drug side effect should be borne in mind in the differential diagnosis and management of advanced-disease patients as it may be confused with local relapse or infectious complication of previously operated areas.

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“…Four cases of capecitabine-induced RRD have been reported thus far, but no erosional manifestation was reported. [1][2][3][4] Thus, the severity of the skin manifestation should not be related to the type of drugs but to the individual immune status. In our case, the patient had pancytopenia due to ALL, implying that the skin manifestation of RRD becomes severer in immunocompromised hosts.…”

Section: Case Of Capecitabine-induced Severe Erosional Radiation Recamentioning

confidence: 99%