A Case of Adult T-Cell Leukemia/Lymphoma in Sphenoid Sinus

Nakao, Yoshio; Tagashira, Nobuharu; Hamai, Yukio; Horibe, Yuichiro; Tanigawa, Tetsuya

doi:10.7248/jjrhi1982.42.2_146

Cited by 2 publications

(4 citation statements)

References 3 publications

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“…Review of the literature identified 16 patients fulfilling the inclusion criteria for this study. 10,13,[15][16][17][18]20,21,[24][25][26][31][32][33][34] The data on these cases and the patient presented in the current study are summarized below. The demographic and clinical presentation data are summarized in Tables 1 and 2…”

Section: Resultsmentioning

confidence: 99%

“…Review of the literature identified 16 patients fulfilling the inclusion criteria for this study. 10,13,15–18,20,21,24–26,31–34 The data on these cases and the patient presented in the current study are summarized below. The demographic and clinical presentation data are summarized in Tables 1 and 2 and in the Table, Supplemental Digital Content 1, Detailed Summary, available at http://links.lww.com/IOP/A230.…”

Section: Resultsmentioning

confidence: 99%

“…42 The involvement of orbit and ocular adnexa by ATLL is frequently accompanied by a precipitous clinical decline, manifesting with leukemic involvement of the blood, CSF, and bone marrow, and nodal and cutaneous dissemination. 21,24,25,31 The importance of CNS evaluation in patients with orbital and ocular adnexal ATLL cannot be overemphasized. 19% of patients with orbital and ocular adnexal ATLL had intracranial involvement of the frontal lobes or pituitary gland, which is in line with the estimated 10-20% rate of CNS progression in aggressive ATLL published by Teshima et al 43 Notably, the Revised ATLL International Consensus Meeting Report recommends diagnostic lumbar puncture and intrathecal chemotherapy for all patients with aggressive ATLL after response to one chemotherapy or antiviral cycle.…”

Section: Demographics and Transmissionmentioning

confidence: 99%

“…Since the first report in the ophthalmic literature by Kabayama et al, most data on ocular adnexal and orbital ATLL have been documented in isolated case reports. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] The absence of cohesive data on the orbital and ocular adnexal manifestations of this rare and aggressive disease can limit its appropriate work-up, timely diagnosis, and appropriate management. Herein, we describe a 20-year-old man with orbital involvement by ATLL as an initial manifestation of his systemic disease and review the presentation, evolving diagnostic modalities, current management trends, and outcomes for all well-documented cases of orbital and ocular adnexal ATLL.…”

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confidence: 99%

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Orbital and Ocular Adnexal Manifestations of Adult T-Cell Leukemia/Lymphoma: a Case Report and Systematic Review

Henry

Bagg

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To describe a patient with orbital adult T-cell leukemia/lymphoma (ATLL) and to review the literature on presentation, diagnostics, management, and clinical course of this rare disease. Methods: A systematic literature review. PubMed/MEDLINE and Google Scholar databases were searched for all well-documented cases of orbital/ocular adnexal ATLL. Results: Sixteen patients were included in the final analysis. The median age at diagnosis was 47 years (range, 20–85), 9/16 patients (56%) were male, and patients were of Japanese (10/16, 63%), Caribbean (5/16, 31%), or African (1/16, 6%) origin. Proptosis (6/15, 40%) and visual loss (5/15, 33%) were the most common presenting signs. Involvement of adjacent structures was documented in 8 of 16 (50%) patients. All patients had evidence of systemic ATLL, which was identified concurrently with orbital/ocular adnexal disease in 9 of 15 (60%) patients. Management included multi-agent chemotherapy with steroids (9/13, 69%), antivirals (2/13, 15%), biologic agents (4/13, 31%), and umbilical cord blood transplantation (1/13, 8%). Most patients (8/12, 67%) experienced at least partial remission with disease relapse occurring in 6 of 8 patients (75%). The median survival time was 28 months (95% CI, 5.5–50.5 months). Conclusions: Adult T-cell leukemia/lymphoma should be considered in the differential diagnosis of orbital and ocular adnexal space-occupying lesions, particularly in male patients from endemic regions. Orbital disease is frequently locally aggressive and presents concurrently with systemic ATLL, highlighting the importance of comprehensive multimodal work-up and multidisciplinary management. Emerging targeted therapies and hematopoietic stem cell transplant may prolong survival.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Demographics and Transmissionmentioning

confidence: 99%

mentioning

confidence: 99%

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Orbital and Ocular Adnexal Manifestations of Adult T-Cell Leukemia/Lymphoma: a Case Report and Systematic Review

Henry

Bagg

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature

Miyagi¹,

Nagasaki²,

Taira³

et al. 2009

Leukemia & Lymphoma

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Extranodal adult T-cell leukemia/lymphoma (ATLL) of the head and neck is a rare disease. We studied the clinicopathological features of nine patients with ATLL involving extranodal head and neck sites and conducted a literature review. Six patients presented with extranodal mass of the head and neck, whereas three had disseminated diseases. Tumors involved the parotid gland, sinonasal tract, masseter muscle, mandible and skull. Histopathology included diffuse pleomorphic-type (with angiocentric features), Hodgkin-like and anaplastic large cell-type. Five patients with localised disease showed prolonged survival regardless of unfavourable histology and/or aberrant provirus status, including integration of multiple copies or defective provirus. Patients with localised disease documented in the literature, including our study series, had a reduced frequency of elevated lactate dehydrogenase, no hypercalcemia and longer survival. ATLL should be included in the differential diagnosis of extranodal head and neck lymphoma. Localised extranodal ATLL of the head and neck may exhibit indolent clinical behaviours.

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A Case of Adult T-Cell Leukemia/Lymphoma in Sphenoid Sinus

Cited by 2 publications

References 3 publications

Orbital and Ocular Adnexal Manifestations of Adult T-Cell Leukemia/Lymphoma: a Case Report and Systematic Review

Orbital and Ocular Adnexal Manifestations of Adult T-Cell Leukemia/Lymphoma: a Case Report and Systematic Review

Extranodal adult T-cell leukemia/lymphoma of the head and neck: a clinicopathological study of nine cases and a review of the literature

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