A Case of Adult-onset Henoch-Schönlein Purpura Triggered by Fire Ants

Abstract

Adult-onset IgA vasculitis, also known as Henoch-Schönlein purpura (HSP), is a rare disease that often presents with a non-blanchable, purpuric rash and can simultaneously affect the gastrointestinal, renal and musculoskeletal systems. The etiology of HSP is unknown. It can be triggered by any entity that creates an immunological insult, including medications, infections and vaccines. We describe a unique case of an adult woman who presented with HSP after experiencing multiple insect bites from fire ants and mosquitos while traveling overseas.

A specific diagnostic metabolome signature in adult IgA vasculitis

“…IgAV is known to occur following infection and is referred to as a “seasonal” disease demonstrated by an epidemiological peak in autumn and winter in children and spring and summer in adults (García-Porrúa et al, 2002 ). In most patients, a virus, bacteria or a drug is a trigger leading to the onset of vasculitis (Brandy-García et al, 2020 ; Endo et al, 2019 ; Itoh et al, 2020 ; Mazumder et al, 2020 ). In adults, IgAV diagnosis is based upon clinical symptoms and laboratory parameters as well as the analysis of a histological sample, e.g., skin or kidney sample which may show IgA deposits.…”

Childhood Immunoglobulin A Vasculitis Associated with COVID-19: A Case Report

“…Other immunological triggers involve several drugs, insect bites, and vaccines, such as the measles vaccine. 5,6 Herein, we presented a case of a girl child patient who developed a confluent palpable purple red rash over both ankles, associated with bilateral ankle edema, tenderness, and a limited range of movement. During hospitalization, she was confirmed to have coronavirus disease 2019 (COVID-19) viral infection in the absence of the respiratory symptoms.…”