A case of acanthosis nigricans as a paraneoplastic syndrome with squamous cell lung cancer

Abstract

A 55-year-old man presented with oral mucosal ulcers, blackening of both hands, and hyperpigmentation on axillary, anal, and inguinal regions for the last 3 months, which were all progressive. The patient was referred to the oncology department with the diagnosis of acanthosis nigricans for investigation of an underlying malignancy. He was a smoker. A computed tomography scan of thorax revealed enlarged mediastinal lymphadenopathies and a lesion on the left upper lobe. Fine-needle aspiration biopsy of the mediastinal lesion was consistent with squamous cell carcinoma, and biopsies of the skin and oral mucosal lesion also further confirmed the diagnosis of acanthosis nigricans. After docetaxel and cisplatin chemotherapy, a significant improvement in his skin and mucosal lesions was observed with almost complete resolution of the pulmonary lesion and the mediastinal lymph nodes.

Efficacy and safety of total glucosides of paeony in the treatment of recurrent aphthous ulcers: a single-center, double-blind, randomized, placebo-controlled clinical trial

“…Recent reviews have found that it was difficult to avoid local infections even if the dosage was controlled within 15 mg/day. In patients with obesity, glaucoma, depression, and hypertension, the dose of 5-10 mg/ day may also cause varying degrees of adverse effects (Karakas et al, 2016). Although the efficacy of thalidomide in the treatment of RAU has been increasingly recognized, some patients may still experience symptoms such as dizziness, constipation, and rash that are difficult to avoid.…”