A case–control study of the risk of upper gastrointestinal mucosal injuries in patients prescribed concurrent NSAIDs and antithrombotic drugs based on data from the Japanese national claims database of 13 million accumulated patients

Sugisaki, Nobuyuki; Iwakiri, Ryuichi; Tsuruoka, Nanae; Sakata, Yasuhisa; Shimoda, Ryo; Fujimoto, S.; Eguchi, Yuichiro; Fujimoto, Kazuma

doi:10.1007/s00535-018-1483-x

Cited by 18 publications

(19 citation statements)

References 69 publications

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“…This database contains integrated medical and pharmacy claims data, including data for inpatients and outpatients from >90 health insurance providers for company employees and their family members as previously described. (13)(14)(15)(16) The JMDC claims database consists of data from relatively younger and more homogeneous populations than the general population in Japan, and patients aged ³75 years are not included. The database includes data on demographics, diagnoses, examinations, and drugs prescribed, including days of supply and dosage information.…”

Section: Methodsmentioning

confidence: 99%

“…The JMDC consists of data for approximately 3.7 million people, including data from health insurance providers for company employees and their families. (13)(14)(15)(16) Although the incidence of upper GI bleeding is influenced by several risk factors and therapeutic approaches, the time transition of the incidence of the GI bleeding evaluated by large amounts of data in a real-world database has not been clearly reported in Japan. The present study was performed to i) examine the time course of the incidence of upper GI bleeding in several recent years (2009-2014) using the relatively large-scale JMDC claims database; ii) compare the incidence of upper GI bleeding, peptic ulcers, and gastroduodenal reflux disease (GERD); and iii) examine the time course of the medications prescribed from 2009 to 2014 in the JMDC claims database.…”

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confidence: 99%

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Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients

Fujimoto

Tsuruoka

Esaki

et al. 2021

J. Clin. Biochem. Nutr.

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This study was to examine the recent trends in upper gastro intestinal bleeding in Japan using a large scale real world database. The incidence of upper gastrointestinal bleeding was evaluated in the Japan Medical Data Center claims database of 13,019,713 patients aged 20 to 74 years with traceability for 3 months from 2009 to 2014. The incidence was compared with peptic ulcers and gastroesophageal reflux disease. The prescrip tion of medications was also evaluated. The incidence of bleeding was 0.137%, 0.121%, 0.113%, 0.106%, 0.099%, and 0.105% during 2009 to 2014 with a time dependent decline (p<0.001). Peptic ulcers (>10 times higher than the incidence of bleeding) decreased with time (p<0.001), whereas gastroesophageal reflux disease increased (p = 0.006). Upper gastrointestinal bleeding was higher in male patients and older patients (60-74 years old) (p<0.001 respectively). The prescription rate of antithrombotic medications and proton pump inhibitors increased from 2009 to 2014 (p<0.001 respectively). The incidence of upper gastrointestinal bleeding decreased from 2009 to 2014 in this relatively large scale real world database in Japan, concomitant with the decrease in peptic ulcers. The decreased incidence might have been due to changes in the disease structure and therapeutic strategies over time.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients

Fujimoto

Tsuruoka

Esaki

et al. 2021

J. Clin. Biochem. Nutr.

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“…17,18 The incidence of short-segment Barrett's esophagus (SSBE) is still relatively high in Japan, and the increase in the prevalence of Barrett's esophagus does not catch up the increase in the gastroesophageal reflux disease in Asian countries including Japan. [16][17][18][19][20][21] Although the definition of Barrett's esophagus differs between Japan and Western countries, [21][22][23][24] the prevalence of Barrett's esophagus is higher in Western countries than in Japan. 17,25,26 Several reports in Western countries have indicated a close relationship between Barrett's esophagus and colorectal neoplasia, 14,[27][28][29][30][31][32][33] but the relationship between these two diseases remains unclear in Japan.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies show that the prevalence of Barrett's esophagus is relatively low in Japan, while other recent studies indicate an increased prevalence . The incidence of short‐segment Barrett's esophagus (SSBE) is still relatively high in Japan, and the increase in the prevalence of Barrett's esophagus does not catch up the increase in the gastroesophageal reflux disease in Asian countries including Japan . Although the definition of Barrett's esophagus differs between Japan and Western countries, the prevalence of Barrett's esophagus is higher in Western countries than in Japan .…”

Section: Introductionmentioning

confidence: 99%

Correlation of Barrett's esophagus with colorectal polyps in Japanese patients: A retrospective chart review

Takedomi

Tsuruoka

Takamori

et al. 2019

J of Gastro and Hepatol

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Background and Aim Barrett's esophagus and colorectal polyps have several overlapping risk factors. Whereas several reports in Western countries have indicated a close relationship between Barrett's esophagus and colorectal polyps, the relationship between these two diseases remains unclear in Japan. This study was performed to determine whether the prevalence of Barrett's esophagus is related to that of colorectal polyps in Japanese patients. Methods The present retrospective chart review included 1582 Japanese patients who underwent both total colonoscopy and esophagogastroduodenoscopy from January 2010 to December 2016. The data on colorectal polyps and Barrett's esophagus were obtained from the endoscopic findings. The medical record of each patient was checked for age, sex, body mass index, smoking, alcohol drinking, use of acid suppression agents, and comorbidities including a history of diabetes, ischemic heart disease, gastroesophageal reflux disease, hiatal hernia, and Helicobacter pylori infection. Results Colorectal polyps were detected in 789 of the 1582 patients (49.9%). Barrett's esophagus was detected in 233 patients (14.7%), and most cases of Barrett's esophagus (n = 229) were classified as short‐segment Barrett's esophagus. Colorectal polyps were more frequent in patients with than without Barrett's esophagus (odds ratio, 1.79; 95% confidence interval, 1.31–2.46; P < 0.001). In addition to Barrett's esophagus, the data indicated that old age, male sex, obesity, smoking, alcohol drinking, diabetes mellitus, and ischemic heart disease were independent risk factors for colorectal polyps. Conclusions The present study revealed the correlation between the prevalence of Barrett's esophagus and colorectal polyps in Japanese patients.

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“…Исследование типа «случай-контроль», проведенное в Японии и охватившее 13 млн человек, показало, что все НПВП (как неселективные, так и селективные), низкие дозы АСК, антикоагулянты и антиагреганты повышают риск развития ГЭРБ (р<0,0001). Для неселективных НПВП ОР составляет 1,54; для селективных -1,41; для малых доз АСК -1,89; для антиагрегантов -1,67 и для антикоагулянтов -1,91 [12]. Использование АСК может вызвать как системные побочные эффекты, так и местное повреждение слизистой оболочки желудочно-кишечного тракта [13].…”

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Gastroesophageal reflux disease and esophagitis associated with the use of drugs: the modern state of the problem

Осадчук¹,

Давыдкин²,

Gricenko³

et al. 2019

Terapevticheskii arkhiv

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From the standpoint of evidence - based medicine, the ability of various drugs to induce the development of gastroesophageal reflux disease and esophagitis is considered. Thus, all known drugs can be divided into 3 groups: drugs that have the ability to reduce pressure in the lower esophageal sphincter, for example, β-adrenoreceptor agonists, α-adrenoreceptor antagonists, anticholinergics, calcium channel blockers, nitrates, benzodiazepines (diazepam), estrogen, progesterone, aminophylline (theophylline), tricyclic antidepressants, selective serotonin reuptake inhibitors, glucocorticosteroids; means providing a direct damaging effect on the esophageal mucosa, as well as lowering its resistance reflyuktatu, e.g., bisphosphonates, acetylsalicylic acid / non - steroidal anti - inflammatory agents, anticoagulants, antiplatelet drugs, iron preparations, ascorbic acid, potassium chloride, quinidine, phenytoin, calcium dobesilate, 131I sodium iodide, antibiotics (tetracycline, doxycycline, clindamycin, ciprofloxacin, ornidazole, clindamycin, rifampicin), antitumor agents; drugs that impede gastric emptying: calcium channel blockers, anticholinergics. These data can be used in practice in the choice of treatment tactics, especially in individuals with a diagnosis of gastroesophageal reflux disease or heartburn.

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A case–control study of the risk of upper gastrointestinal mucosal injuries in patients prescribed concurrent NSAIDs and antithrombotic drugs based on data from the Japanese national claims database of 13 million accumulated patients

Abstract: This case-control study using the large organized Japanese claims database provided the risk of upper GI mucosal injuries in patients receiving NSAIDs and antithrombotic drugs.

Cited by 18 publications

References 69 publications

Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients

Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients

Correlation of Barrett's esophagus with colorectal polyps in Japanese patients: A retrospective chart review

Gastroesophageal reflux disease and esophagitis associated with the use of drugs: the modern state of the problem

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