A cascade nanoreactor for enhancing sonodynamic therapy on colorectal cancer via synergistic ROS augment and autophagy blockage

Aptamer-Modified Zinc Ferrite Nanoparticles for Autophagy-Mediated Chemotherapy and MR Imaging of Ovarian Cancer

“…CQ is a downstream autophagy inhibitor that inhibits lysosomal hydrolases and prevents autophagosome−lysosome fusion, thus effectively preventing LC3-II degradation. 38,39 We found that CQ also significantly reduced the level of cell death caused by ZFONPs and restored cell viability (Figure 2F,G). In addition, Western blot analysis showed that treatment with CQ resulted in a significant increase in the level of LC3-II protein expression (Figure 2H).…”

Dual-targeting nanotheranostics for MRI-guided enhanced chemodynamic therapy of hepatoma via regulating the tumor microenvironment

“…4A) revealed slight green fluorescence in the PBS group, which is due to endogenous ROS production in these cells. 45 SMCC-7721 cells treated with only H 2 O 2 , FM@TCM, or FM@TCM + H 2 O 2 exhibited green fluorescence, and the latter group showed significantly stronger fluorescence intensity than the other two groups (Fig. 4C).…”

Nanozyme: a rising star for cancer therapy

“…Zhang's group also incorporated an autophagy inhibitor and Ce6 together into a homologous tumor cell membrane-modified hollow polydopamine nanocarrier pre-doped with Pt nanozymes (CCP@HP@M). 60 HP exhibited SOD-like activity capable of converting O 2…”

“…Zhang's group also incorporated an autophagy inhibitor and Ce6 together into a homologous tumor cell membrane-modified hollow polydopamine nanocarrier pre-doped with Pt nanozymes (CCP@HP@M). 60 HP exhibited SOD-like activity capable of converting O 2 ˙ − to O 2 and H 2 O 2 , while the POD and CAT-like activities of the Pt nanozymes could further catalyze the excess H 2 O 2 to produce ˙OH and O 2 for effectively alleviating hypoxia, which resulted in a significant increase of SDT efficiency and stimulated apoptosis and ferroptosis. Zhao and Huang conjugated PdPt bimetallic nanozymes with glucose oxidase (GOx) and sonosensitizer IR780 (PdPt@GOx/IR780) (Fig.…”