A carrier-free, dual-functional hydrogel constructed of antimicrobial peptide Jelleine-1 and 8Br-cAMP for MRSA infected diabetic wound healing

Zhou, Jingjing; Wang, Zhanhui; Yang, Changyan; Zhang, Hanru; Fareed, Muhammad Subaan; He, Yuhang; Su, Jie; Wang, Panpan; Shen, Zhiqiang; Yan, Wenjin; Wang, Kairong

doi:10.1016/j.actbio.2022.07.066

Cited by 31 publications

(26 citation statements)

References 62 publications

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“…Wang et al. developed an antibacterial hydrogel from the natural antibacterial peptide Jelleine-1 (J-1) and 8-Bromoadenosine-3′, 5′-cyclic monophosphate (8Br-cAMP) using π-π interactions and hydrogen bond [ 72 ]. Among them, peptides assembled by hydrophobic interactions and hydrogen bonds [ 73 ], J-1 could self-assemble into nanofibers in the 8Br-cAMP phosphate solution and interwove to form a nanofiber network of sufficient density to trap water molecules to form a self-supporting hydrogel.…”

Section: Fabrications Of Hydrogel Dressingmentioning

confidence: 99%

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Recent progress of antibacterial hydrogels in wound dressings

Jia¹,

Li²,

Cao³

et al. 2023

Materials Today Bio

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Section: Fabrications Of Hydrogel Dressingmentioning

confidence: 99%

Section: Fabrications Of Hydrogel Dressingmentioning

confidence: 99%

Recent progress of antibacterial hydrogels in wound dressings

Jia¹,

Li²,

Cao³

et al. 2023

Materials Today Bio

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“…with antibacterial peptides Jelleine‐1(J‐1) and 8 ‐ bromo adenosine‐3′, 5′‐cyclic monophosphate (8BR‐camp) can promote the healing of diabetic wounds infected by MRSA. [ 207 ]…”

Section: Biomedical Potential Of Antibacterial Hydrogels With Fixed A...mentioning

confidence: 99%

“…[201] The carrier-free bifunctional hydrogel constructed by Zhou et al with antibacterial peptides Jelleine-1(J-1) and 8bromo adenosine-3′, 5′-cyclic monophosphate (8BR-camp) can promote the healing of diabetic wounds infected by MRSA. [207] Peptides are a promising alternative to antibiotics that physically disrupt the cell membrane of bacteria, resulting in rapid bactericidal activity. Embedding antimicrobial peptides in hydrogels or combining antimicrobial peptides with hydrogels can effectively improve the performance of hydrogels and make them more versatile for future development.…”

Section: Biomedical Potential Of Antimicrobial Peptide Hydrogelsmentioning

confidence: 99%

Antimicrobial Hydrogels: Potential Materials for Medical Application

Li,

Han,

et al. 2023

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Microbial infections based on drug‐resistant pathogenic organisms following surgery or trauma and uncontrolled bleeding are the main causes of increased mortality from trauma worldwide. The prevalence of drug‐resistant pathogens has led to a significant increase in medical costs and poses a great threat to the normal life of people. This is an important issue in the field of biomedicine, and the emergence of new antimicrobial materials hydrogels holds great promise for solving this problem. Hydrogel is an important material with good biocompatibility, water absorption, oxygen permeability, adhesion, degradation, self‐healing, corrosion resistance, and controlled release of drugs as well as structural diversity. Bacteria‐disturbing hydrogels have important applications in the direction of surgical treatment, wound dressing, medical device coating, and tissue engineering. This paper reviews the classification of antimicrobial hydrogels, the current status of research, and the potential of antimicrobial hydrogels for one application in biomedicine, and analyzes the current research of hydrogels in biomedical applications from five aspects: metal‐loaded hydrogels, drug‐loaded hydrogels, carbon‐material‐loaded hydrogels, hydrogels with fixed antimicrobial activity and biological antimicrobial hydrogels, and provides an outlook on the high antimicrobial activity, biodegradability, biocompatibility, injectability, clinical applicability and future development prospects of hydrogels in this field.

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“…[10] Our previous studies showed that J-1 hydrogels formed by J-1 in adenosine diphosphate (ADP) sodium salt solution, and 8-bromine cyclic adenosine monophosphate (8Br-cAMP) sodium salt solution exhibited significant antibacterial, hemostatic, anti-adhesion, or wound healing effects, and good biocompatibility, indicating that they had good clinical application potential. [11] J-1 hydrogels, on the other hand, need to be enhanced in terms of stability, mechanical strength, and protease stability as biomedical materials. Given the excellent properties of d-amino acids as peptide molecular or material building blocks, D-J-1 was synthesized and D-J-1 hydrogel was prepared in the current study to improve the application of J-1 hydrogels and better understand the effects of d-amino acids on the self-assembly properties, biocompatibility, stability, and biological functions of J-1 hydrogel.…”

Section: Introductionmentioning

confidence: 99%

The Antimicrobial, Hemostatic, and Anti‐Adhesion Effects of a Peptide Hydrogel Constructed by the All‐d‐Enantiomer of Antimicrobial Peptide Jelleine‐1

Zhang

Zhou

et al. 2023

Adv Healthcare Materials

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Peptide hydrogels were believed to be potential biomaterials with wide application in the biomedical field because of their good biocompatibility, injectability, and three‐dimensional (3D) printability. Most of the previously reported polypeptide hydrogels are composed of L‐peptides, while the hydrogels formed by self‐assembly of D‐peptides are rarely reported. Herein, we reported a peptide hydrogel constructed by D‐J‐1, which was the all‐D‐enantiomer of antimicrobial peptide Jelleine‐1. Field emission scanning electron microscope (FE‐SEM) and rheologic study were performed to characterize the hydrogel. Antimicrobial, hemostatic, and anti‐adhesion studies were carried out to evaluate its biofunction. Our results showed that D‐J‐1 hydrogel was formed by self‐assembly and cross‐linking driven by hydrogen bonding, hydrophobic interaction, and π‐π stacking force of aromatic ring in the structure of D‐J‐1. It exhibited promising antimicrobial activity, hemostatic activity, and anti‐adhesion efficiency in a rat sidewall defect‐cecum abrasion model. In addition, it also exhibited good biocompatibility. Notably, D‐J‐1 hydrogel showed improved in vitro and in vivo stability when compared with its L‐enantiomer J‐1 hydrogel. Therefore, the present study would provide new insight into the application of D‐peptide hydrogel, and provide a new peptide hydrogel with antibacterial, hemostatic, and anti‐adhesion efficacy for clinical use.This article is protected by copyright. All rights reserved

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A carrier-free, dual-functional hydrogel constructed of antimicrobial peptide Jelleine-1 and 8Br-cAMP for MRSA infected diabetic wound healing

Cited by 31 publications

References 62 publications

Recent progress of antibacterial hydrogels in wound dressings

Recent progress of antibacterial hydrogels in wound dressings

Antimicrobial Hydrogels: Potential Materials for Medical Application

The Antimicrobial, Hemostatic, and Anti‐Adhesion Effects of a Peptide Hydrogel Constructed by the All‐d‐Enantiomer of Antimicrobial Peptide Jelleine‐1

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