A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands

Li, Guoming; Zheng, Shaoqin; Zhang, Zhenyan; Hu, Yan-Shan; Lin, Nansong; Julie, Nadia; Shu, Lei; Sun, Limei; Zhang, Hongying; Yuan, Yueming; Liang, Yuan; Yu, Zhengjie; Xie, W.; Mwaisiga, Ridley; Morewaya, Jacob; Xu, Qin; Shen, Jianping; Deng, Changsheng

doi:10.1016/j.pmedr.2023.102154

Cited by 2 publications

(3 citation statements)

References 22 publications

(32 reference statements)

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“…Recently, WHO approved the use of a first-generation vaccine107 and this review identified one study in Kenya where ACE was used to educate the caregivers of children of the vaccine’s benefits and to deliver malaria vaccination at health facilities 32. Likewise, WHO recommends MDA (using artemisinin and piperaquine combination) as a prevention measure to accelerate malaria elimination in countries with moderate transmission rates and confined transmission settings, such as islands 108. Often these HS interventions also include HE on MDA to inform communities of its role in malaria prevention and control 14 73.…”

Section: Discussionmentioning

confidence: 99%

“… 32 Likewise, WHO recommends MDA (using artemisinin and piperaquine combination) as a prevention measure to accelerate malaria elimination in countries with moderate transmission rates and confined transmission settings, such as islands. 108 Often these HS interventions also include HE on MDA to inform communities of its role in malaria prevention and control. 14 73 Our review found higher MDA participation rates in communities where HS activities were combined with HE, 14 73 and involved local community leaders.…”

Section: Discussionmentioning

confidence: 99%

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Community engagement approaches for malaria prevention, control and elimination: a scoping review

Awasthi,

Jancey,

Clements

et al. 2024

BMJ Open

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IntroductionGlobally malaria programmes have adopted approaches to community engagement (ACE) to design and deliver malaria interventions. This scoping review aimed to understand, map, and synthesise intervention activities guided by ACE and implemented by countries worldwide for the prevention, control and elimination of malaria.MethodsThree databases (Web of Science, Proquest, and Medline) were searched for peer-reviewed, primary studies, published in English between 1 January 2000 and 31 December 2022. Advanced Google was used to search for grey literature. The five levels of the International Association for Public Participation were used to categorise ACE - (1) Inform, (2) Consult, (3) involve, (4) Collaborate, and (5) Co-lead. Intervention activities were categorised as health education (HE), and/or health services (HS), and/or environmental management (EM). Outcomes were collected as knowledge, attitude, behaviour, help-seeking, health and HS and environment. Enablers and barriers were identified. Malaria intervention phases were categorised as (1) prevention (P), or (2) control (C), or (3) prevention and control (PC) or prevention, control and elimination (PCE).ResultsSeventy-five studies were included in the review. Based on ACE levels, most studies were at the inform (n=37) and involve (n=26) level. HE (n=66) and HS (n=43) were the common intervention activities. HE informed communities about malaria, its prevention and vector control. EM activities were effective when complemented by HE. Community-based HS using locally recruited health workers was well-accepted by the community. Involvement of local leaders and collaboration with local stakeholders can be enablers for malaria intervention activities.ConclusionInvolving local leaders and community groups in all stages of malaria prevention programmes is vital for successful interventions. Key elements of successful ACE, that is, consult, collaborate, and co-lead were under-represented in the literature and require attention. National programes must consult and collaborate with community stakeholders to develop ownership of the interventions and eventually co-lead them.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Community engagement approaches for malaria prevention, control and elimination: a scoping review

Awasthi,

Jancey,

Clements

et al. 2024

BMJ Open

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“…Artemisinin and its derivatives are the rst-choice antimalarial drugs worldwide [9]. A campaign for artemisinin/DHA-piperaquine administration was conducted in malaria-endemic areas and was veri ed as safe and effective in improving malaria protection and decreasing malaria incidence [10][11]. In addition to malaria treatment, artemisinin and its derivatives have anti-in ammatory and immunoregulatory activities [12][13][14].…”

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confidence: 99%

Dihydroartemisinin inhibits the susceptibility of Anopheles stephensi to Plasmodium by activating Toll signaling pathway

Liu,

Zheng,

Wang

et al. 2024

Preprint

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Background Malaria is a serious public health concern. Artemisinin and its derivatives are first-line drugs for the treatment of Plasmodium falciparum malaria. In mammals, artemisinin exhibits potent anti-inflammatory and immunoregulatory properties. However, it is unclear whether artemisinin plays a regulatory role in the innate immunity of mosquitoes, thereby affecting the development of Plasmodium in Anopheles when Artemisinin and its metabolites enter mosquitoes. This study aimed to determine the effect of DHA, a first-generation semisynthetic derivative of artemisinin, on innate immunity and malaria vector competence of Anopheles stephensi. Methods Anopheles stephensi was fed Plasmodium-infected mice treated with dihydroartemisinin (DHA) via gavage, Plasmodium-infected blood containing DHA in vitro, or DHA-containing sugar, followed by Plasmodium yoelii infection. The engorged female mosquitoes were separated and dissected 8 days after infection. Plasmodium oocysts were counted and compared between the control and DHA-treated groups. Additionally, total RNA and proteins were extracted from engorged mosquitoes 24 and 72 h post-infection (hpi). Real-time PCR and western blotting were performed to detect the transcriptional levels and protein expression of immune molecules in mosquitoes. Finally, the Toll signaling pathway was inhibited via RNAi and the infection intensity was analyzed to confirm the role of the Toll signaling pathway in the effect of DHA on the vector competence of mosquitoes. Results DHA treatment via different approaches significantly reduced the number of Plasmodium oocysts in mosquitoes. The transcriptional levels of anti-Plasmodium immune genes, including TEP1, LRIM1, and APL1C; Toll pathway genes, including Tube, MyD88, and Rel1; and the effector Defensin 1, were upregulated by DHA treatment at 24 and 72 hpi. TEP1 and Rel1 protein expression was significantly induced under DHA treatment. However, Rel1 knockdown in DHA-treated mosquitoes abrogated DHA-mediated refractoriness to Plasmodium infection. Conclusions DHA treatment effectively inhibited the development of P. yoelii in An. stephensi by upregulating mosquitoes’ Toll signaling pathway, thereby influencing the susceptibility of Anopheles to Plasmodium.

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A campaign of mass drug administration with artemisinin-piperaquine to antimalaria in Trobriand Islands

Cited by 2 publications

References 22 publications

Community engagement approaches for malaria prevention, control and elimination: a scoping review

Community engagement approaches for malaria prevention, control and elimination: a scoping review

Dihydroartemisinin inhibits the susceptibility of Anopheles stephensi to Plasmodium by activating Toll signaling pathway

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