Journal of Cell Biology volume 217, issue 8, P2877-2890 2018 DOI: 10.1083/jcb.201710132 View full text Has correction 2019-03-09
Scott W. Messenger, Sang Su Woo, Zhongze Sun, Thomas F.J. Martin

Abstract: Messenger et al. show that exosome secretion in cancer cells is Ca2+-stimulated and dependent on Ca2+-bound Munc13-4. Munc13-4, a late endosome priming factor, acts via a Rab11-dependent pathway to prepare multivesicular endosomes for exocytosis. These results indicate that Munc13-4 plays a central role in exosome release in cancer cells.

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