A brief review of physiological roles, plant resources, synthesis, purification and oxidative stability of Alpha-linolenic Acid

Tang, Yao Jiang Yuhan; Meng, Jun Tao Jiasong

doi:10.9755/ejfa.2018.v30.i5.1676

Cited by 3 publications

(2 citation statements)

References 146 publications

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“…Alpha-linolenic acid (ALA) occupies a special place in the family of omega-3 acids-it is a precursor of other FAs of the omega-3 family, i.e., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Numerous studies have demonstrated the beneficial effect of ALA in the prevention and treatment of many diseases, e.g., central nervous system disorders, cardiovascular diseases, and some types of cancer [3,20,21]. However, considering linseed oil as a source of ALA, it should be remembered that the complexity of its composition remains a controversial issue.…”

Section: Introductionmentioning

confidence: 99%

An Attempt to Enrich Pig Meat with Omega-3 Fatty Acids Using Linseed Oil Ethyl Ester Diet Supplement

et al. 2021

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This study aims to evaluate an effect of pig diet supplementation with ethyl esters derived from linseed oil with a high content of alpha-linolenic acid (ALA) on the fatty acids profile of meat. The study was conducted on Polish Landrace fatteners supplemented for a period of 7 weeks (control and experimental groups of 8 animals each, 16 in total). After this period, loin (Longissimus dorsi) and ham (Biceps femoris) samples were collected for laboratory analysis, including basic composition (fat, protein, ash, dry matter) and fatty acids (FAs) profile. The supplementation caused a significant increase in the level of ALA acid, decrease in the content of saturated fatty acids (SFAs), increase in unsaturated FAs level, and resulting decrease in the ratio of n-6/n-3. The indices of atherogenicity and thrombogenicity were beneficially altered in the experimental groups. It can thus be supposed that meat enriched this way may be considered as an interesting choice for consumers who are aware of the importance of diet consumed.

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Section: Introductionmentioning

confidence: 99%

An Attempt to Enrich Pig Meat with Omega-3 Fatty Acids Using Linseed Oil Ethyl Ester Diet Supplement

et al. 2021

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“…S5). (KEGG Pathway database (https://www.genome.jp/kegg/pathway.html), Ali et al, 2010;Castellarin et al, 2007b;Dong and Lin, 2021;Clifford et al, 2017;Petrussa et al, 2013;Tang YuHan et al, 2018;Yang et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

The single-berry metabolomic clock paradigm reveals new stages and metabolic switches during grapevine berry development

Tavernier,

Savoi,

Torregrosa

et al. 2024

Preprint

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SummaryAsynchronous development of berries causes metabolic chimerism in usual samples. We thus revisited the developmental changes in the metabolome of theVitis viniferasingle berries from anthesis to over-ripening.A dataset of 9,256 ions obtained by non-targeted ultra-performance liquid chromatography coupled to high-resolution mass spectrometry was submitted to an analysis workflow combining classification and dimension reduction tools, to reveal the dynamics of metabolite composition without phenologicala priori.This approach led to a metabolome-based definition of developmental stages, as well as the clustering of metabolites into 12 specific kinetic patterns. The single berry intrinsic metabolomic clock alleviates constitutive asynchronicity biases in the usual combination of phenological scales and observer clock. Such increase in temporal resolution enabled the identification of metabolite clusters annunciative of the onset of ripening since the herbaceous plateau. In particular, these clusters included transient lipidic changes and the start of ABA accumulation. We also highlighted a cluster of stilbenes that accumulate after sugar loading stops, during fruit shriveling.This non-targeted approach enables a more precise and unbiased characterization of grapevine berry development through the metabolomic clock paradigm. The discovery of new metabolic milestones of berry development paves the way towards an unbiased assessment of berry physiological stages.

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Antiproliferative Ability and Fluorescence Tracking of α-Linolenic Acid-Loaded Microemulsion as Label-Free Delivery Carriers in MDA-MB-231 Cells

Liu

Wang

et al. 2019

J. Agric. Food Chem.

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In this work, the effects of α-linolenic acid (ALA) loaded in oil-in-water (O/W) and water-in-oil-in-water (W/O/W) microemulsions on cell viability, lactic dehydrogenase (LDH) viability, and reactive oxygen species (ROS) levels were examined using Cell Counting Kit-8 (CCK-8), an LDH assay kit, and a fluorescence microscope, respectively. The CCK-8 assay demonstrated that ALA inhibited MDA-MB-231 human breast cancer cell proliferation in a dose-dependent manner. Further, the results of LDH activity and ROS levels revealed that ALA-induced cancer cell damage was closely related to oxidative stress. Under the irradiation of ultraviolet light, the microemulsion without any added fluorescent dye would emit bright blue fluorescence, and the fluorescent images of the cells treated with ALA-loaded O/W and W/O/W microemulsions at different incubation times were taken, which exhibited long-term photostability and biocompatibility. In addition, the fluorescence mechanism of the microemulsion was explained by immobilizing surfactant molecules with aggregation-induced emission (AIE) properties at the water–oil interface through the microemulsion with a self-assembled structure. These findings showed the potential application of O/W and W/O/W microemulsions as the label-free delivery carriers in long-term imaging of living cells and real-time release monitoring of nutrients.

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A brief review of physiological roles, plant resources, synthesis, purification and oxidative stability of Alpha-linolenic Acid

Cited by 3 publications

References 146 publications

An Attempt to Enrich Pig Meat with Omega-3 Fatty Acids Using Linseed Oil Ethyl Ester Diet Supplement

An Attempt to Enrich Pig Meat with Omega-3 Fatty Acids Using Linseed Oil Ethyl Ester Diet Supplement

The single-berry metabolomic clock paradigm reveals new stages and metabolic switches during grapevine berry development

Antiproliferative Ability and Fluorescence Tracking of α-Linolenic Acid-Loaded Microemulsion as Label-Free Delivery Carriers in MDA-MB-231 Cells

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