A Breast Cancer Nomogram for Prediction of Non-Sentinel Node Metastasis - Validation of Fourteen Existing Models

Koca, Bülent; Kuru, Bekir; Özen, Nurten; Yoruker, Savas; Bek, Yüksel

doi:10.7314/apjcp.2014.15.3.1481

Cited by 27 publications

(34 citation statements)

References 39 publications

(104 reference statements)

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“…This result stated the aggravated risk corolated with tumour size. In the present study; LVI, the number of positive SLNs, extracapsular extension and the positive SLN ratio (proportion of positive SLN to total SLN) were the other factors affecting non-SLN metastasis risk in univariate analysis compatible with literature [22][23][24]. However, only the positive SLN ratio showed significance in multivariate analysis (p=0.005).…”

Section: Discussionsupporting

confidence: 84%

See 1 more Smart Citation

The Accuracy of Memorial Sloan-Kettering Cancer Center Nomogram in Anatolian Breast Cancer Patients

Erdoğan¹,

Yuksel²,

Berberoğlu³

et al. 2016

Acta Oncol Tur.

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ÖZETAmaç: Bir çok meme kanseri hastasında sentinel lenf nodundan başka metastatik lenf nodu olmadığı halde gereksiz yere aksiller diseksiyon uygulanmaktadır. Bu çalışmanın amacı Memorial Sloan-Kettering Cancer Center (MSKCC) nomogramının Anadolu'da yaşayan meme kanseri hastalarındaki doğruluğunu araştırmaktır. Gereç ve yöntem: Sentinel lenf nodu (SLN) biyopsisi pozitif olduğu için aksiller lenf nodu diseksiyonu yapılan 120 meme kanserli hastanın hasta ve tümör özellikleri irdelendi. Bu hastaların her birisinin non-SLN tutulum riski MSKCC nomogramı kullanılarak hesaplandı. Bulgular: Negatif SLN sayısı, pozitif SLN sayısı, SLN ekstrakapsüler yayılımı, pozitif SLN sayısının toplam SLN sayısına oranı (pozitif SLN oranı), lenfovasküler invazyon varlığı, tumor çapı, human epidermal growth factor receptor-2 durumu tek değişkenli analizde non-SLN metastazı ile istatistiksel olarak ilişkili bulunan faktörlerdi. Çok değişkenli analizde ise tümör çapı ≥ 5cm (p<0.036) ve pozitif SLN oranı (p<0.005) non-SLN metastazı ile ilişkili bulunan parametrelerdi. Nomogramın sonucuna göre ROC eğrisi çizildi ve eğri altı alan 0,779 (p<0.001) olarak bulundu. Sonuç: SLN pozitif meme kanserli hastalarda non-SLN metastaz riskini belirlemede MSKCC nomogramı bizim hasta populasyonumuz için iyi bir ayıraç olmuştur. Anahtar kelimeler: Meme kanseri, nomogramlar, lenf nod diseksiyonu ABSTRACT Background and Aim: Many breast cancer patients undergo to unnecessary axillary dissection as additional nodal metastasis is not detected other than sentinel lymph node in most of the patients. This study is conducted to establish the accuracy of Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram in Anatolian patients. Materials and Methods: One hundred and twenty sentinel lymph node (SLN) biopsy positive breast cancer patients who received completion axillary lymph node dissection were reviewed according to patient and tumour characteristics. The likelihood of having positive non-SLN metastasis based on the factors and the performance of the diagnostic value of MSKCC nomogram were evaluated. Results: The number of negative SLNs, the number of positive SLNs, SLN extracapsular extention, proportion of positive SLNs to total SLNs (positive SLN ratio), lymphovascular invasion, tumor size, human epidermal growth factor receptor-2 status were found statistically significant on non-SLN metastasis in univariate analysis. Tumor size ≥ 5cm (p<0.036) and positive SLN ratio (p<0.005) were found to be correlated with non-SLN metastasis in multivariate analysis. Receiver operating characteristic (ROC) curve was formed according to the nomogram and areas under curve (AUC) was found as 0,779 (p<0.001). Conclusions: The MSKCC nomogram was good discriminator of non-SLN metastasis in SLN positive breast cancer patients for our patient population.

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Section: Discussionsupporting

confidence: 84%

“…Tumour size is also reported as a related factor with non-SLN metastasis in some other various studies [21][22][23]. In our study, there was significance between the non-SLN positive and negative groups according to mean tumour size (p=0.002) and in multivariate analysis tumour size over 5 cm.…”

Section: Discussionsupporting

confidence: 72%

The Accuracy of Memorial Sloan-Kettering Cancer Center Nomogram in Anatolian Breast Cancer Patients

Erdoğan¹,

Yuksel²,

Berberoğlu³

et al. 2016

Acta Oncol Tur.

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“…The number of sentinel lymph nodes dissected and the ratio of metastatic/dissected sentinel nodes, tumor burden in metastatic sentinel node and extracapsular invasion to the surrounding tissue were investigated using both univariant and multivariant analyses and found related with non-sentinel lymph node involvement in various studies (17)(18)(19)(20)(21)(22). Considering our findings, it can be stated that when more than half of the dissected sentinel nodes are infiltrated, the likelihood of having metastasis in the rest of the axillary lymph nodes significantly increases.…”

Section: Discussionmentioning

confidence: 99%

Factors Influencing Non-sentinel Node Metastasis in Patients with Macrometastatic Sentinel Lymph Node Involvement and Validation of Three Commonly Used Nomograms

Güven¹,

Doğan²,

Kültüroğlu³

et al. 2017

Eur J Breast Health

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“…Based on the identified predictors of NSLNM in different studies, several nomograms have been developed to predict the presence of tumor in NSLNs in the axilla (Van Zee et al, 2003;Barranger et al, 2005;Kohrt et al, 2008;Pal et al, 2008;Gur et al, 2010;Koca et al, 2014). The most widely used nomogram is developed by Memorial Sloan-Kettering Cancer Center (MSKCC) (Van Zee et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic Features Predicting Involvement of Nonsentinel Axillary Lymph Nodes in Iranian Women with Breast Cancer

Moosavi

Abdirad²,

Omranipour³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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, and the number of positive sentinel lymph nodes to the total number of harvested sentinel lymph nodes ratio (OR=20.2; 95% CI, 3.4-121.9), were significantly associated with non-sentinel lymph node metastasis. Conclusions: According to this study, age, primary tumor size, lymphovascular invasion, extracapsular invasion, and the ratio of positive sentinel lymph nodes to the total number of harvested sentinel lymph nodes, were found to be independent predictors of non-sentinel lymph node metastasis.

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A Breast Cancer Nomogram for Prediction of Non-Sentinel Node Metastasis - Validation of Fourteen Existing Models

Cited by 27 publications

References 39 publications

The Accuracy of Memorial Sloan-Kettering Cancer Center Nomogram in Anatolian Breast Cancer Patients

The Accuracy of Memorial Sloan-Kettering Cancer Center Nomogram in Anatolian Breast Cancer Patients

Factors Influencing Non-sentinel Node Metastasis in Patients with Macrometastatic Sentinel Lymph Node Involvement and Validation of Three Commonly Used Nomograms

Clinicopathologic Features Predicting Involvement of Nonsentinel Axillary Lymph Nodes in Iranian Women with Breast Cancer

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