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Cited by 2 publications
(4 citation statements)
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“…Recent studies extend MYC 's broad activity to the entire non-coding transcriptome, including a larger and far less explored segment of the non-coding transcriptome, long non-coding RNAs (lncRNAs), which typically form functional secondary and higher order structures comprising protein-protein or protein-nucleic acid complexes [ 25 ]. LncRNAs are operationally defined as any non-protein-coding RNA > 200 nt in length, which corresponds to a convenient cut-off in biochemical fractionation and excludes all known classes of small RNAs [ 26 ].…”
Section: Functional Regulation (Transcription Micro-rnas and Apoptosmentioning
confidence: 99%
See 1 more Smart Citation
“…Recent studies extend MYC 's broad activity to the entire non-coding transcriptome, including a larger and far less explored segment of the non-coding transcriptome, long non-coding RNAs (lncRNAs), which typically form functional secondary and higher order structures comprising protein-protein or protein-nucleic acid complexes [ 25 ]. LncRNAs are operationally defined as any non-protein-coding RNA > 200 nt in length, which corresponds to a convenient cut-off in biochemical fractionation and excludes all known classes of small RNAs [ 26 ].…”
Section: Functional Regulation (Transcription Micro-rnas and Apoptosmentioning
confidence: 99%
“…However, for selected genes, these data have been independently validated for specific lncRNAs by determining steady-state RNA levels by qRT-PCR and direct transcriptional effects by nuclear run-on experiments. This data is augmented by visualization with global epigenetic and MYC ChIP data [ 25 ].…”
Section: Functional Regulation (Transcription Micro-rnas and Apoptosmentioning
confidence: 99%
“…Hence, DNA replication is both under transcriptional and non-transcriptional control by Myc. As a huge expansion of its regulatory sphere, MYC also controls virtually the entire non-coding transcriptome (Weinberg et al 2015). MYC regulates the expression of miRNAs, short RNA molecules that regulate the half-life or translational efficiency of target mRNAs (Mendell 2005, 2008; Croce 2009; Di Leva et al 2014).…”
Section: Cellular Signalingmentioning
confidence: 99%
“…Deregulated MYC genes are a driving force in the majority of all human cancers (Vogt 2012; Dang 2012; Vogelstein et al 2013; Stine et al 2015; Tokheim et al 2016), and MYC was dubbed the emperor of oncogenes (Weinberg et al 2015). MYC , MYCN , and MYCL were listed in the census of human cancer genes (Futreal et al 2004) and classified as driver genes in cancer genome landscapes (Vogelstein et al 2013).…”
Section: Tumorigenesismentioning
confidence: 99%