1994
DOI: 10.1038/371423a0
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Abstract: Phosphorylation of the neurofilament proteins of high and medium relative molecular mass, as well as of the Alzheimer's tau protein, is thought to be catalysed by a protein kinase with Cdc2-like substrate specificity. We have purified a novel Cdc2-like kinase from bovine brain capable of phosphorylating both the neurofilament proteins and tau. The purified enzyme is a heterodimer of cyclin-dependent kinase 5 (Cdk5) and a novel regulatory subunit, p25 (ref. 8). When overexpressed and purified from Escherichia c… Show more

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Cited by 555 publications
(508 citation statements)
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References 23 publications
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“…The CDKAL1 has a domain similar to CDK5 regulatory subunit-associated protein 1 (CDK5RAP1), a neuronal protein that specifically inhibits activation of CDK5. 15 The reduced expression of CDKAL1 enhances activity of CDK5 in b cells and thus decreases insulin secretion. 16 The function of the CDKAL1 on insulin secretion would be influenced by alternative splicing.…”
Section: Discussionmentioning
confidence: 99%
“…The CDKAL1 has a domain similar to CDK5 regulatory subunit-associated protein 1 (CDK5RAP1), a neuronal protein that specifically inhibits activation of CDK5. 15 The reduced expression of CDKAL1 enhances activity of CDK5 in b cells and thus decreases insulin secretion. 16 The function of the CDKAL1 on insulin secretion would be influenced by alternative splicing.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, CDK9, whose expression is ubiquitous , shows an increased kinase activity in terminally di erentiated tissues (Bagella et al, 1998). This is similar to the CDK5 kinase, whose expression also appears not to be cell cycle dependent, and is higher in di erentiated tissues (Lew et al, 1994;Tsai et al, 1994). Because B-Myb is involved in mutually antagonistic interactions with factors associated with cell di erentiation and gene transcription, such as the retinoblastoma family member p107 (Sala et al, 1996b;Raschella' et al, 1997), we asked whether CDK9 could interfere with B-Myb activity.…”
Section: Introductionmentioning
confidence: 90%
“…Only one CDK appears to be involved in cell cycle regulation in budding and ®ssion yeast (Elledge, 1996) while diverged, multiple members exist in higher eukaryotes. In higher eukaryotes, the di erent members play distinct functions in certain points of the cell cycle (reviewed by Sherr, 1993;Pines, 1995), and additional role in postmitotic neurons has been demonstrated for CDK5 (Tsai et al, 1994;Lew et al, 1994), and have also been suggested for other CDKs (Freeman et al, 1994). Similarly, only one member of the NIMA family probably exists in Aspergillus (Osmani and Ye, 1996), while mammals have at least six NIMA-related genes (Letwin et al, 1992;Schultz et al, 1994;Lu and Hunter, 1995).…”
Section: Discussionmentioning
confidence: 99%
“…The activity of the CDKs is regulated at the di erent stages of the cell-cycle through reversible phosphorylation, and by binding of the CDKs to di erent cyclins, activators and inhibitors (Tsai et al, 1994;Lew et al, 1994;Morgan, 1995;Pines, 1995;Sherr and Roberts, 1995). The onset of mitosis is controlled by p34 cdc2 (CDK1), which form with its regulator, a B-type cyclin, a complex known as maturation, or mitosis promoting factor (MPF) (Nurse and Bissett, 1981;Lohka et al, 1988;Gautier et al, 1988;Arion et al, 1988;Simanis and Nurse, 1986;Minshull et al, 1989).…”
Section: Introductionmentioning
confidence: 99%