A bone substitute composed of polymethylmethacrylate and α-tricalcium phosphate: results in terms of osteoblast function and bone tissue formation

Fini, Milena; Giavaresi, Gianluca; Aldini, N. Nicoli; Torricelli, Paola; Botter, R.; Beruto, D.; Giardino, Roberto

doi:10.1016/s0142-9612(02)00196-5

Cited by 108 publications

(91 citation statements)

References 37 publications

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“…The current implants were machined with a lathe out of pre-polymerized PMMA rods, while in the Ooms study the PMMA implants had to polymerize in situ, which results in prolonged release of cytotoxic monomer. This explanation is supported by other studies [13][14][15][16], who all used pre-polymerized implants, which evoked a moderate non-compatible bone response characterized by the occurrence of reduced bone contact and a thin separating fibrous tissue layer.…”

Section: Discussionsupporting

confidence: 73%

Evaluation of bone response to titanium-coated polymethyl methacrylate resin (PMMA) implants by X-ray tomography

Shalabi

Wolke

Cuijpers

et al. 2007

J Mater Sci: Mater Med

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High-resolution three-dimensional data about the bone response to oral implants can be obtained by using microfocus computer tomography. However, a disadvantage is that metallic implants cause streaking artifacts due to scattering of X-rays, which prevents an accurate evaluation of the interfacial bone-to-implant contact. It has been suggested that the use of thin titanium coatings deposited on polymeric implants can offer an alternative option for analyzing bone contact using micro-CT imaging. Consequently, the aim of the current study was to investigate bone behavior to titanium-coated polymethylmethacrylate (PMMA) implants by micro-CT and histological evaluation. For the experiment titanium-coated PMMA implants were used. The implants had a machined threaded appearance and were provided with a 400-500 nm thick titanium coating. The implants were inserted in the right or left tibia of 10 goats. After an implantation period of 12 weeks the implants were retrieved and prepared for micro-computer tomography (lCT), light microscopy, and X-ray microanalysis. The micro-CT showed that the screwthreads and typical implant configuration were well maintained through the installation procedure. Overall, histological responses showed that the titanium-coated implants were well tolerated and caused no atypical tissue response. In addition, the bone was seen in direct contact with the titanium-coated layer. The X-ray microanalysis results confirmed the light microscopical data. In conclusion, the obtained results proof the final use of titanium-coated PMMA implants for evaluation of the bone-implant response using lCT. However, this study also confirms that for a proper analysis of the bone-implant interface the additional use of microscopical techniques is still required.

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Section: Discussionsupporting

confidence: 73%

Evaluation of bone response to titanium-coated polymethyl methacrylate resin (PMMA) implants by X-ray tomography

Shalabi

Wolke

Cuijpers

et al. 2007

J Mater Sci: Mater Med

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“…Apparently, the inclusion of b-TCP particles improves the bone response better than exclusively polymethylmethacrylatebased materials, which is consistent with previous investigations studying calcium phosphate-based bone cements. [30][31][32][33] In percutaneous transpedicular vertebroplasty, but also in other orthopedic and dental procedures, it is important to obtain optimal binding between bone and implanted material. The inclusion of bone antiresorptive agents might contribute to faster and enhanced ingrowth of new bone into bone cement composites with greater bone density in the implant surroundings.…”

Section: Discussionmentioning

confidence: 99%

No Increased Bone Formation around Alendronate or Omeprazole Loaded Bioactive Bone Cements in a Femoral Defect

Bodde

Kowalski²,

Spauwen

et al. 2008

Tissue Engineering Part A

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Alendronate and omeprazole have been found to influence bone healing by interfering with osteoclastic activity, resulting in increased bone formation. The biological effect of these conventional drugs, incorporated into bioactive bone cement (G2B1), was investigated in a rabbit model. The 2 materials and a control were inserted in defects created in the femoral condyle of rabbits. Implantation time was 6 and 12 weeks. After retrieval, micro-computed tomography and histomorphometry were performed to quantify bone mineral density (BMD) and bone volume (BV) of the implant-surrounding bone mass and the percentage of bone-to-implant contact. BMD and BV were similar in all groups. The percentage of bone-to-implant contact was significantly lower in the alendronate and omeprazole groups than in controls after 6 weeks of implantation. After 12 weeks, this difference in bone contact disappeared for the omeprazole but not for the alendronate implants, which were almost completely surrounded by a fibrous capsule, associated with a limited inflammatory response. In conclusion, in the current study, alendronate and omeprazole did not result in better bone healing when incorporated into bioactive bone cement than did plain control implants. Moreover, an additional cytotoxicity assay revealed that alendronate evoked a toxic response.

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“…The favorable physicochemical properties, such as high thermal stability, 37 little shrinkage, 38,39 high strength, and toughness, 40 which make epoxy become popular in science and industry areas. It is widely used in the fields of adhesives, 41 anti-corrosion coatings, 42 tissue substitutes, 43 electronics, 44 aerospace. 45 and so on.…”

Section: Introductionmentioning

confidence: 99%

Magnetic epoxy nanocomposites with superparamagnetic MnFe2O4 nanoparticles

et al. 2015

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Manganese iron oxide (MnFe2O4) nanoparticles successfully served as nanofillers for obtaining magnetic epoxy nanocomposites. The viscosities of MnFe2O4/epoxy resin liquid suspensions increased with increasing the nanoparticles loading except the suspension with 5.0 and 1.0 wt% loading, whose viscosities were lower than that of pure epoxy. The introduction of MnFe2O4 nanoparticles showed a lower onset decomposition temperature and glass transition temperature (Tg), which decreased with increasing the nanoparticles loading. The storage modulus and tensile strength of 1.0 wt% MnFe2O4/epoxy were a little higher than that of pure epoxy. The coercivity of MnFe2O4/epoxy nanocomposites with 5.0 wt% (44.7 Oe) and 10.0 wt% (43.9 Oe) displayed much higher than that of pure MnFe2O4 nanoparticles (14.94 Oe). The magnetic moment (m) of nanocomposites (1.354 μB for 10 wt% MnFe2O4/epoxy) are higher than that of pure MnFe2O4 nanoparticles (1.244 μB). The increased real permittivity observed in the nanocomposites was attributed to the interfacial polarization. The intrinsic permittivity of the MnFe2O4 nanoparticles was also calculated.

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A bone substitute composed of polymethylmethacrylate and α-tricalcium phosphate: results in terms of osteoblast function and bone tissue formation

Cited by 108 publications

References 37 publications

Evaluation of bone response to titanium-coated polymethyl methacrylate resin (PMMA) implants by X-ray tomography

Evaluation of bone response to titanium-coated polymethyl methacrylate resin (PMMA) implants by X-ray tomography

No Increased Bone Formation around Alendronate or Omeprazole Loaded Bioactive Bone Cements in a Femoral Defect

Magnetic epoxy nanocomposites with superparamagnetic MnFe2O4 nanoparticles

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