A biosensor material with robust mechanical properties, fatigue-resistance, biocompatibility, biodegradability, and anti-freezing capabilities

Wei, Yanqiang; Jiang, Shuaicheng; Li, Jiongjiong; Li, Xiaona; Kuang, Li; Gu, Wenbin; Fang, Zhen

doi:10.1039/d1ta10998g

Cited by 7 publications

(5 citation statements)

References 64 publications

(90 reference statements)

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“…[47][48][49] To minimize freezing and drying, which occur in conventional hydrogels, the binary solvent and zwitterion were used as media and functional filler, respectively, which lowers the freezing temperature by interrupting the hydrogen bonds in ice crystals and slows the rate of drying by reducing vapor pressure (Figure 1b,c). [50][51] Moreover, the Na + , H + , and AgNPs in the solvent make the NSD-Gel e-skin conductive, and the NSD-Gel e-skin possesses hypersensitivity to strain due to deformation can effectively change the ion transport path and time (Figure 1d). [52][53] Furthermore, due to the zwitterions' hydrophilic functional groups, betaines are properly dispersed in the solution, which ensures a continuously conductive network entangled with the collagen fiber bundles.…”

Section: Design and Fabrication Of Nsd-gel E-skinmentioning

confidence: 99%

Mechanically Robust and Transparent Organohydrogel‐Based E‐Skin Nanoengineered from Natural Skin

Bai

Wang

Zheng

et al. 2023

Adv Funct Materials

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Electronic skins (e‐skins), which are mechanically compliant with human skin, are regarded as ideal electronic devices for noninvasive human–machine interaction and wearable devices. In order to fully mimic human skin, e‐skins should possess reliable mechanical properties and be able to resist external environmental factors like heat, cold, desiccation, and bacteria, while perceiving multiple external stimuli, such as temperature, humidity, and strain. Here, a transparent, mechanically robust, environmentally stable, versatile natural skin‐derived organohydrogel (NSD‐Gel) is nanoengineered through the integration of betaine, silver nanoparticles, and sodium chloride in a glycerol/water binary solvent. The transparent NSD‐Gel e‐skin exhibits outstanding tensile strength (7.33 MPa), puncture resistance, moisture retention, self‐regeneration, and antibacterial properties. Additionally, the NSD‐Gel e‐skin possesses enhanced cold/heat resistance and stimuli‐responsive characteristics that effectively sense environmental temperature and humidity changes, as well as physiological human body motion signals. In vitro and in vivo experiments show that the NSD‐Gel e‐skin confers desired biocompatibility and tissue protective properties even in extremely harsh environments (−196 °C to 100 °C). The NSD‐Gel e‐skin has great potential for applications in multidimensional wearable electronic devices, human‐machine interfaces, and artificial intelligence, generating a versatile platform for the development of high‐performance e‐skins with on‐demand properties.

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Section: Design and Fabrication Of Nsd-gel E-skinmentioning

confidence: 99%

Mechanically Robust and Transparent Organohydrogel‐Based E‐Skin Nanoengineered from Natural Skin

Bai

Wang

Zheng

et al. 2023

Adv Funct Materials

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“…The elongation at break and tensile strength of SPI‐BT@PDA@PANI film material reached up to 72.4% and 36.3 ± 2.5 MPa at a stretching rate of 20 mm min −1 ( Figure a and Figure S3, Supporting Information), with a concomitant high toughness around 21.25 ± 1.5 MJ m −3 (Figure S4, Supporting Information), which were simultaneously 3.4 and 5 times higher than that of SPI‐BT film material (10.8 MPa and 4.26 MJ m −3 , respectively), mainly attributed to an efficient strain energy dissipation owing to the stable and firm organic–inorganic hybrid interpenetrating network by intermolecular hydrogen bonding and electrostatic interaction between BT@PDA@PANI and SPI. The tensile strength and toughness of SPI‐BT@PDA@PANI biomaterial were clearly not only higher than other previously materials (2–19 and 2–11 times higher than those of most previously materials, Figure 4b,c; Tables S2 and S3, respectively, Supporting Information), [ 37,44–48 ] but also higher than that of traditional PE plastics (about 15–30 MPa). The storage modulus ( E ′) of SPI‐BT@PDA@PANI film material gradually increased (Figure 4d), and the loss factor (tan δ) curve raised from 119.1 to 130.8 °C (Figure 4e), implying that BT@PDA@PANI promoted the construction of the organic–inorganic hybrid interpenetrating network structure in SPI‐BT@PDA@PANI film material, endowing it superior strength and high toughness.…”

Section: Resultsmentioning

confidence: 60%

Scalable Manufacturing of Environmentally Stable All‐Solid‐State Plant Protein‐Based Supercapacitors with Optimal Balance of Capacitive Performance and Mechanically Robust

Jiang

Wei

et al. 2023

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widespread adoption and short functional lifetime of traditional energy storage devices will bound to cause global environmental impact (such as e-waste and electronic equipment). [3] Although a large number of studies are reported on novel energy storage devices to tackle this epidemic, such as bio-based hydrogels, [4] film materials. [5] However, hydrogels with conductive nanofiller as energy storage materials are usually made with a tremendous amount of water, [6] and lack integrity and tunability of internal structure and composition, which are generally fragile, mechanically unstable, and poorly water-resistant. [7] Especially, chemical crosslinking and chemical modification methods are commonly required to process polymeric hydrogels, which inevitably suffer from toxic chemicals, complex processing procedures, and high energy consumption. [8] In contrast, film materials are considered to be promising candidates for flexible energy storage materials because of their high conductivity, excellent chemical stability, and excellent merits in energy storage and other applications. [9] To date, methods for preparing film materials, such as vacuumassisted filtration, spin coating, and spray coating, have been developed and shown to have potential applications in fields such as flexible electronics, energy conversion, supercapacitors, and electromagnetic interference shielding. [10] Although film materials may provide outstanding results, most of theseThe development of advanced biomaterial with mechanically robust and high energy density is critical for flexible electronics, such as batteries and supercapacitors. Plant proteins are ideal candidates for making flexible electronics due to their renewable and eco-friendly natures. However, due to the weak intermolecular interactions and abundant hydrophilic groups of protein chains, the mechanical properties of protein-based materials, especially in bulk materials, are largely constrained, which hinders their performance in practical applications. Here, a green and scalable method is shown for the fabrication of advanced film biomaterials with high mechanical strength (36.3 MPa), toughness (21.25 MJ m −3 ), and extraordinary fatigue-resistance (213 000 times) by incorporating tailor-made core-double-shell structured nanoparticles. Subsequently, the film biomaterials combine to construct an ordered, dense bulk material by stacking-up and hot-pressing techniques. Surprisingly, the solidstate supercapacitor based on compacted bulk material shows an ultrahigh energy density of 25.8 Wh kg −1 , which is much higher than those previously reported advanced materials. Notably, the bulk material also demonstrates long-term cycling stability, which can be maintained under ambient condition or immersed in H 2 SO 4 electrolyte for more than 120 days. Thus, this research improves the competitiveness of protein-based materials for real-world applications such as flexible electronics and solid-state supercapacitors.

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“…The NPs were deposited on a nylon membrane that covered an ion sensitive electrode (ISE) to detect the ammonium ions (NH 4 + ) emitted in the reaction of L-asparagine with L-asparaginase. Furthermore, a promising strategy in the development of a new generation of multifunctional flexible wearable biosensors can be seen in the work proposed by Wei et al [ 227 ]. Specifically, a combination of strawberry-type BaTiO 3 (BT) inorganic particles, soy protein isolate (SPI) chains, polyethylene glycol-200 (PEG-200), and glycerin (GL) to fabricate an SPI-based membrane material (SPI-BT@Ag0.5) was proposed ( Figure 4 c).…”

Section: Promising Applications Of Nanomembranes and Nanoparticles In...mentioning

confidence: 99%

Advances in Functionalization of Bioresorbable Nanomembranes and Nanoparticles for Their Use in Biomedicine

Mohammed-Sadhakathullah,

Paulo-Mirasol,

Torras

et al. 2023

IJMS

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Bioresorbable nanomembranes (NMs) and nanoparticles (NPs) are powerful polymeric materials playing an important role in biomedicine, as they can effectively reduce infections and inflammatory clinical patient conditions due to their high biocompatibility, ability to physically interact with biomolecules, large surface area, and low toxicity. In this review, the most common bioabsorbable materials such as those belonging to natural polymers and proteins for the manufacture of NMs and NPs are reviewed. In addition to biocompatibility and bioresorption, current methodology on surface functionalization is also revisited and the most recent applications are highlighted. Considering the most recent use in the field of biosensors, tethered lipid bilayers, drug delivery, wound dressing, skin regeneration, targeted chemotherapy and imaging/diagnostics, functionalized NMs and NPs have become one of the main pillars of modern biomedical applications.

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A biosensor material with robust mechanical properties, fatigue-resistance, biocompatibility, biodegradability, and anti-freezing capabilities

Abstract: A mechanically durable, biocompatible, and frost-resistant protein-based biosensor with biomimetic nanoparticles has been fabricated, and it can be used to monitor physiological signals and movement states.

Cited by 7 publications

References 64 publications

Mechanically Robust and Transparent Organohydrogel‐Based E‐Skin Nanoengineered from Natural Skin

Mechanically Robust and Transparent Organohydrogel‐Based E‐Skin Nanoengineered from Natural Skin

Scalable Manufacturing of Environmentally Stable All‐Solid‐State Plant Protein‐Based Supercapacitors with Optimal Balance of Capacitive Performance and Mechanically Robust

Advances in Functionalization of Bioresorbable Nanomembranes and Nanoparticles for Their Use in Biomedicine

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