A Biomedical Sensor for Detection of Cancer Cells Based on Terahertz Metamaterial Absorber

Banerjee, Sagnik; Dutta, Purba; Jha, Amitkumar V.; Appasani, Bhargav; Khan, Mohammad S.

doi:10.1109/lsens.2022.3178918

Cited by 37 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metamaterials are artificially fabricated and periodically arranged structures of dielectric and/or sub-wavelength metallic elements also known as THz metamaterial absorbers (TMA) which make use of their rich spectral fingerprinting in the EM region. They are unique structures that exhibit unique properties such as anomalous reflection, negative refractive index, sub-diffraction limited focusing, cloaking and optical magnetism with ability to absorb the incident EM radiation [144], [145]. Additionally, metamaterials that have well designed structures are capable of sensitive detection of minute/ thin biological and chemical substances through enhanced and strongly localized fields [146].…”

Section: F Thz For Treatment Of Cancermentioning

confidence: 99%

“…In other words, the THz metamaterials' resonance frequency is comparable to biomolecular vibrational frequency, the biomolecules include cancer biomarkers. One such study proposed a design that merged circular ring resonators on a gallium arsenide substrate which achieved 99% absorption at 3.71THz, 1447GHz/RIU sensitivity with 92.75 quality factor (Q-factor) and resonance frequency that shifts with altering the encompassing medium's refractive index in the range 1.3-1.40 for cancer cell detection [144].…”

Section: F Thz For Treatment Of Cancermentioning

confidence: 99%

“…Highly sensitive and specific THz metamaterial biosensors were also fabricated for cancer detection [144], pancreatic cancer biomarker called exosomal microRNA with high accuracy [154], CA125 and CA199 cancer biomarkers [155], type A549 lung cancer cells [156], carcinoma cells [157], [158], [159], [160], skin cancer [114], [161], breast cancer [162], [163], colon cancer [164]. Plasmon based metamaterial biosensors that use Graphene were also proposed that are a breakthrough invention due to being highly sensitive, low cost prototyping, fabrication, design and inherent configurability [151], [165], [166], [167], [168], [169], [170].…”

Section: F Thz For Treatment Of Cancermentioning

confidence: 99%

See 2 more Smart Citations

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Gezimati

Singh

2023

IEEE Access

View full text Add to dashboard Cite

There is a keen interest in the exploration of new generation emitters and detectors due to advancements in innovation of new materials and device processing technologies which have opened up new frontiers in the Terahertz (THz) spectrum. Therefore, it is necessary to review the developments in THz technology for healthcare applications, their impact, implications and prospects for ongoing research and development. This paper provides a broad overview of the current status and prospects of application of THz imaging and sensing for the healthcare domain. We present current knowledge, identify existing challenges for wide scale clinical adoption of THz systems and prospective opinions to facilitate research and development towards optimized and miniaturized THz systems and biosensors that provide real operational convenience through emerging trends. Firstly, we provide an overview of the THz imaging and sensing techniques that exploit properties of THz generation and detection with emphasis on terahertz time domain spectroscopy (THz-TDS) and THz Metamaterials. The mechanisms of tissue image contrast and the application of THz imaging and sensing for biomedical applications in particular, the cancer detection application is reported. Secondly, an outlook toward the advancements in THz technology in the interface of healthcare 4.0 and its enabling technologies is explored for next generation smart and connected healthcare systems. Third, we identify the merits and existing challenges in THz cancer imaging and sensing and suggest prospective opinions to pave way to ongoing and future research. Further, we discuss the recent advances in THz imaging development and the contribution of near-field techniques based on plasmonic, and resonance based metasurfaces, waveguides etc. for breaking the diffraction limit towards development of THz systems that are convenient for point of care. We bring researchers a roadmap for future research scope.

show abstract

Section: F Thz For Treatment Of Cancermentioning

confidence: 99%

Section: F Thz For Treatment Of Cancermentioning

confidence: 99%

Section: F Thz For Treatment Of Cancermentioning

confidence: 99%

See 1 more Smart Citation

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Gezimati

Singh

2023

IEEE Access

View full text Add to dashboard Cite

show abstract

“…Knowing that the back plate reflection coefficient is negative unity (r 23 = −1), part of the incident waves is reflected ( ⇀ r 21 = r 21. e ∅21 ) and transmitted ( ⇀ t 21 = t 21. e ∅21 ) at the air-spacer interface. Consequently, the total reflection coefficient of the structure can be calculated as follows [40]:…”

Section: Absorption Response and Polarization Angle Tolerancementioning

confidence: 99%

“…This can find applications in THz sensing, particularly in biomedical applications. Biomedical samples have refractive indexes in the range of 1.3-1.4 [40], where the sensor can be employed to detect the sample. Thus, the work has merits in terms of the design's angle and polarization insensitivity and the device's ability to act as a dual sensor.…”

Section: Introductionmentioning

confidence: 99%

A polarization-insensitive triple-band perfect metamaterial absorber incorporating ZnSe for terahertz sensing

Abdulkarim

Alkurt

Bakır

et al. 2022

J. Opt.

Self Cite

View full text Add to dashboard Cite

In this work, a triple-band polarization-insensitive metamaterial structure with perfect absorption is proposed, based on a ZnSe substrate is incorporated. The structure was optimally designed by varying the type of substrate and the unit cell dimensions. The structure was simulated using the finite integration technique, and the results showed that the proposed design achieved a near-perfect absorption of about 99%, 99%, and 100% at 22.50 THz, 28.98 THz, and 35.14 THz, respectively. Its absorption characteristics are invariant to the changes in the angle of incidence, making it an ideal absorber. Further investigations on the electric field, magnetic field, and surface current distributions were carried out to elaborate on the absorption characteristics at various resonance frequencies. The proposed design can also be used as a sensor that can detect the depth of the surrounding analyte and its refractive index. The design can detect the depth of the analyte with a peak sensitivity of 2.76 THz/μm and its refractive index with a peak sensitivity of 1.55 THz/RIU. Thus, the design can have significant terahertz sensing applications.

show abstract

Terahertz imaging technology for localization of cancer tumours: a technical review

Gezimati,

Singh

2023

Multimed Tools Appl

View full text Add to dashboard Cite

Currently, cancer is a large contributing factor in the increased mortality rates and at present the predictions are estimating an increased trend. The conventional medical cancer imaging modalities, for example X-Ray and Computed Tomography use ionizing radiation which is not tissue friendly for repeated assessments. The Terahertz (THz) cancer imaging offers novel opportunities for non-ionizing, non-invasive and early cancer detection, or diagnosis as well as improved cancer patient treatment follow-ups. In this review, a broad overview is given on the potential of THz radiation-based imaging and sensing as a technique for detection of various cancers cells. The THz radiation dynamics and interaction mechanisms with biological systems as well as parameter extraction and modelling for the observed THz image contrast are studied. The experimental studies on THz imaging and sensing are investigated with the goal approach to investigate the ex vivo, in vitro, and in vivo observations. The use of advanced analytic algorithms, specifically deep learning, is proposed for improved detection, discrimination of complex tissue with overlapping dielectric properties and development of clinical decision support systems. Research gaps in the THz imaging studies are identified based on recent trends, latest strategies suggested and the roadmap for future research direction provided.

show abstract

A Biomedical Sensor for Detection of Cancer Cells Based on Terahertz Metamaterial Absorber

Cited by 37 publications

References 19 publications

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

A polarization-insensitive triple-band perfect metamaterial absorber incorporating ZnSe for terahertz sensing

Terahertz imaging technology for localization of cancer tumours: a technical review

Contact Info

Product

Resources

About