A Biodegradable Metal‐Polymer Composite Stent Safe and Effective on Physiological and Serum‐Containing Biomimetic Conditions

Zhang, Hongjie; Zhang, Wanqian; Qiu, Hong; Gui, Zhilun; Li, Xin; Qi, Haiping; Guo, Jingzhen; Qian, Jie; Shi, Xiaoli; Xian, Gao; Shi, Daokun; Zhang, Deyuan; Gao, Runlin; Ding, Jiandong

doi:10.1002/adhm.202201740

Cited by 26 publications

(24 citation statements)

References 84 publications

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“…We employed the mold casting method to fabricate the patterned surfaces, as schematically presented in Figure S2, and the topography was controlled with varied array parameters, in particular, heights and diameters. Here, we choose PLLA as the raw material because PLLA as well as its copolymer such as poly(lactide- co -glycolide) (PLGA) is a kind of polymeric biomaterials widely used in biodegradable implants, − and we choose human umbilical vein endothelial cells (HUVECs) as the model cell type because this is an important cell type widely used in biomaterial studies, in particular for cardiovascular systems. − Roughness, plateau coverage, stereo coverage, and overall stiffness were calculated and correlated to adhesion behaviors of cells on different micropatterns. It is verified that these important parameters can semi-quantify the effects of surface topography on cell adhesion.…”

Section: Introductionmentioning

confidence: 99%

Stereo Coverage and Overall Stiffness of Biomaterial Arrays Underly Parts of Topography Effects on Cell Adhesion

Wang

Liu

Gao

et al. 2023

ACS Appl. Mater. Interfaces

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Surface topography is a biophysical factor affecting cell behaviors, yet the underlying cues are still not clear. Herein, we hypothesized that stereo coverage and overall stiffness of biomaterial arrays on the scale of single cells underly parts of topography effects on cell adhesion. We fabricated a series of microarrays (micropillar, micropit, and microtube) of poly(L-lactic acid) (PLLA) using mold casting based on pre-designed templates. The characteristic sizes of array units were less than that of a single cell, and thus, each cell could sense the micropatterns with varied roughness. With human umbilical vein endothelial cells (HUVECs) as the model cell type, we examined spreading areas and cell viabilities on different surfaces. "Stereo coverage" was defined to quantify the actual cell spreading fraction on a topographic surface. Particularly in the case of high micropillars, cells were confirmed not able to touch the bottom and had to partially hang among the micropillars. Then, in our opinion, a cell sensed the overall stiffness combining the bulk stiffness of the raw material and the stiffness of the culture medium. Spreading area and single cell viability were correlated to coverage and topographic feature of the prepared microarrays in particular with the significantly protruded geometry feather. Cell traction forces exerted on micropillars were also discussed. These findings provide new insights into the surface modifications toward biomedical implants.

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Section: Introductionmentioning

confidence: 99%

Stereo Coverage and Overall Stiffness of Biomaterial Arrays Underly Parts of Topography Effects on Cell Adhesion

Wang

Liu

Gao

et al. 2023

ACS Appl. Mater. Interfaces

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“…The aforementioned results indicated that SMEN had good histocompatibility and potential application value. Before ending our discussion of a ROS‐responsive exosome coating of nitinol for interventional stent, it seems worthy of noting the effect of serum proteins on ROS, pointed out very recently by Ding team in their assessment of the potential cytotoxicity during their research and development of the next‐generation biodegradable cardiovascular device for interventional treatment along with the first clinical case, [ 73 ] based on their new concept of metal–polymer composite stent. [ 74 ] Both of their in vitro and in vivo examinations support the strong effects of physiological conditions, in particular serum proteins, on biocompatibility of an implant.…”

Section: Discussionmentioning

confidence: 99%

Preparation of ROS‐Responsive Exosome Coating of Nitinol Material for Making the Neurointerventional Stent

Duan

et al. 2023

Adv Materials Inter

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Nitinol (NiTi) alloy is an ideal material for preparing neurointerventional stents due to its excellent mechanical properties and biocompatibility. However, NiTi stents without surface‐specific functionalization cause a high rate of stent thrombosis and in‐stent restenosis after implantation. In ischemic stroke, exosomes have a role in regulating nervous system development, regeneration, vascular remodeling, and neuroinflammation. In this work, the effect of exosome coating on the biocompatibility of NiTi alloy is evaluated. NiTi alloy is successively immersed in relevant solution (sodium alginate, 3‐aminophenylboronic acid, distearoylphosphatidylethanolamine, and exosomes) to form ROS‐responsive exosome coated surfaces. In vitro experiments (platelets, endothelial cells, smooth muscle cells, and macrophages) and in vivo subcutaneous implantation experiments are performed to test coatings for biocompatibility. The results show that the modified NiTi alloy surface has high hydrophilicity, which has the functions of inhibiting platelet aggregation, promoting endothelialization, inhibiting smooth muscle cell migration, anti‐inflammatory, and good tissue biocompatibility. This study develops exosome neurointerventional stent coating as a bioactive drug via reactive oxygen species accumulation in lesions, thus targeting drug release, inhibiting intimal hyperplasia, and reducing inflammation and thrombosis.

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“…With the development of biomaterials [ 48–53 ], the biodegradable type has been the front of medical devices [ 54–57 ], and some corrodible metals have been tried as the skeletal materials [ 58–60 ]. Even a metal-polymer composite stent has been into clinical research [ 61 , 62 ]. Our equation is expected to be a new tool to investigate biodegradable medical devices and assist the evaluation and choice of the biomaterial.…”

Section: Disscusionmentioning

confidence: 99%

Establishment of coverage-mass equation to quantify the corrosion inhomogeneity and examination of medium effects on iron corrosion

Ding

2023

Regenerative Biomaterials

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Metal corrosion is important in the fields of biomedicine as well as construction and transportation etc. While most corrosion occurs inhomogeneously, there is so far no satisfactory parameter to characterize corrosion inhomogeneity. Herein, we employ the Poisson raindrop question to model the corrosion process and derive an equation to relate corrosion coverage and corrosion mass. We also suggest corrosion mass at 50% coverage, termed as half-coverage mass Mcorro50%, as an inhomogeneity parameter to quantify corrosion inhomogeneity. The equation is confirmed and the half-coverage mass Mcorro50%, is justified in our experiments of iron corrosion in five aqueous media, normal saline (NS), phosphate buffered saline (PBS), Hank’s solution (HS), deionized water (DI), and artificial seawater (AS), where the former three ones are biomimetic and very important in studies of biomedical materials. The half-coverage mass Mcorro50%, is proved to be more comprehensive and mathematically convergent than the traditional pitting factor. Iron corrosion is detected using visual observation, scanning electron microscopy with a build-in energy dispersive spectrometer, inductive coupled plasma emission spectrometry, and electrochemical measurements. Both rates and inhomogeneity extents of iron corrosion are compared among the five aqueous media. The factors underlying the medium effects on corrosion rate and inhomogeneity are discussed and interpreted. Corrosion rates of iron in the five media differ about 7 folds, and half-coverage mass values differ about 300,000 folds. The fastest corrosion and the most significant inhomogeneity occur both in biomimetic media, but not the same one. The new equation and the new quantity are stimulating for dealing with a dynamic and stochastic process with inhomogeneity including but not limited to metal corrosion. The findings are meaningful for research and development of biomaterials.

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A Biodegradable Metal‐Polymer Composite Stent Safe and Effective on Physiological and Serum‐Containing Biomimetic Conditions

Cited by 26 publications

References 84 publications

Stereo Coverage and Overall Stiffness of Biomaterial Arrays Underly Parts of Topography Effects on Cell Adhesion

Stereo Coverage and Overall Stiffness of Biomaterial Arrays Underly Parts of Topography Effects on Cell Adhesion

Preparation of ROS‐Responsive Exosome Coating of Nitinol Material for Making the Neurointerventional Stent

Establishment of coverage-mass equation to quantify the corrosion inhomogeneity and examination of medium effects on iron corrosion

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