A biodegradable, injectable, gel system based on MPEG-b-(PCL-ran-PLLA) diblock copolymers with an adjustable therapeutic window

Kang, Young Sook; Lee, Sang Hyo; Lee, Ju Young; Son, Jin Soo; Kim, Byung Soo; Lee, Bong; Chun, Heung Jae; Min, Byoung Hyun; Kim, Jae Ho; Kim, Moon Suk

doi:10.1016/j.biomaterials.2009.11.115

Cited by 106 publications

(68 citation statements)

References 21 publications

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“…51 Kang et al investigated diblock copolymers, where the first block was based on methoxy poly(ethylene glycol) (MPEG) and the second block on both CL and LLA units, randomly distributed. 52 The CL/LLA ratio was varied and only polymers with a high ratio formed gels of which the T gel decreased with increasing CL content. This was attributed to the enhanced crystallinity of the polymer when increasing the CL content.…”

Section: Effect Of Composition/ Hydrophobicitymentioning

confidence: 99%

Tuning the gelation of thermoresponsive gels

Constantinou

Georgiou

2016

European Polymer Journal

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Thermoresponsive gels are exciting polymeric materials with many biomedical applications in medical devices, drug delivery, tissue engineering and bio-printing. Also, they have great potential to be used in 3-D printing and thus in the fabrication of many different devices and materials. As it is crucial for the application of these gels to be able to control and tailor the gelation temperature and concentration this was the main focus and point of discussion of this feature article. Thus, it is discussed in detail how by varying the molar mass, composition, stereochemistry and architecture the thermoresponsive properties of these gels are altered.

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Section: Effect Of Composition/ Hydrophobicitymentioning

confidence: 99%

Tuning the gelation of thermoresponsive gels

Constantinou

Georgiou

2016

European Polymer Journal

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“…Previously, we developed MPEG-b-PCL (MP) and MPEG-b-polyester diblock copolymers, (MPEG-b-(PCL-ran-PLLA), MPEG-b-(PCL-ran-poly(trimethylene carbonate)), and MPEG-b-(PCLran-poly(1,4-dioxan-2-one)), as thermogelling materials [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…polyesters, such as poly(L-lactic acid) (PLLA), poly(glycolic acid), their copolyesters, or poly(ε-caprolactone) (PCL), have been reported as potential thermogelling candidates [8][9][10][11][12]. Previously, we developed MPEG-b-PCL (MP) and MPEG-b-polyester diblock copolymers, (MPEG-b-(PCL-ran-PLLA), MPEG-b-(PCL-ran-poly(trimethylene carbonate)), and MPEG-b-(PCLran-poly (1,4-dioxan-2-one)), as thermogelling materials [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Pendant Group-Functionalized Diblock Copolymers with Adjustable Thermogelling Behavior

Lee

Park

et al. 2017

Polymers

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Abstract:Recently, several thermogelling materials have been developed for biomedical applications. In this study, we prepared methoxy polyethylene glycol (MPEG)-b-(poly(ε-caprolactone)-ran-poly(2-chloride-ε-caprolactone) (PCL-ran-PfCL)) (MP-Cl) diblock copolymers at room temperature via the ring-opening polymerization of caprolactone (CL) and 2-chloride-ε-caprolactone (fCL) monomers, using the terminal alcohol of MPEG as the initiator in the presence of HCl. MPEG-b-(poly(ε-caprolactone)-ran-poly(2-azide-ε-caprolactone) (PCL-ran-PCL-N 3 )) (MP-N 3 ) was prepared by the reaction of MP-Cl with sodium azide. MPEG-b-(poly(ε-caprolactone)-ran-poly(2-amine-ε-caprolactone) (PCL-ran-PCL-NH 2 )) (MP-NH 2 ) was subsequently prepared by Staudinger reaction. MP-Cl and MP-N 3 showed negative zeta potentials, but MP-NH 2 had a positive zeta potential. MP-Cl, MP-N 3 , and MP-NH 2 solutions formed opaque emulsions at room temperature. The solutions exhibited a solution-to-hydrogel phase transition as a function of the temperature and were affected by variation of the chloride, azide, and the amine pendant group, as well as the amount of pendant groups present in their structure. Additionally, the phase transition of MP-Cl, MP-N 3 , and MP-NH 2 copolymers was altered by pendant groups. The solution-to-hydrogel phase transition was adjusted by tailoring the crystallinity and hydrophobicity of the copolymers in aqueous solutions. Collectively, MP-Cl, MP-N 3 , and MP-NH 2 with various pendant-group contents in the PCL segment showed a solution-to-hydrogel phase transition that depended on both the type of pendant groups and their content.

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“…Various injectable drug depots, like those using collagen, gelatin, hyaluronate, cellulose, and fibrin, as well as synthetic materials, have been developed for this purpose (Kim et al, 2011;Kang et al, 2010;Lee et al, 2010;Yang et al, 2009;Yu and Ding, 2008;Lupton and Alster, 2000). Among them, collagen has the advantage of mimicking many features of the extracellular matrix (ECM) of mammals and it has high mechanical strength, good biocompatibility, low antigenicity, and water-uptake properties (Bhang et al, 2009;Kim et al, 2009;Ruozi et al, 2009;Pollack, 1999;Wallace and Rosenblatt, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, we investigated SIS sheets and sponges for use as scaffolds for tissue engineering (Ahn et al, 2007;Kim et al, 2006Kim et al, , 2007aKim et al, ,b, 2010. SIS could be prepared as a SIS suspension via SIS powder through a variety of processing steps, including mechanical manipulation, digestion, and sterilization.…”

Section: Introductionmentioning

confidence: 99%