A Behavioral Paradigm for the Evaluation of

Unaided Smoking Cessation

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Lost in translation? Moving contingency management and cognitive behavioral therapy into clinical practice

“…During the induction phase, about 40% of patients drop out during the first month of treatment and 60% drop out by 3 months . In the 1970s, preliminary evaluations of behavioral interventions used to address naltrexone's weaknesses, including providing financial incentives for compliance with naltrexone, suggested the promise of these strategies. However, these interventions were not widely adopted.…”

Intranasal oxycodone self-administration in non-dependent opioid abusers.

“…Self-administration has been successfully adapted for use in the human laboratory to study the reinforcing efficacy of opioids, including heroin and prescription opioids (e.g., oxycodone), and to assess potential pharmacotherapies for substance use disorders (Comer et al, 2008). The earliest human studies examined the reinforcing efficacy of heroin, methadone, or hydromorphone under an array of conditions, including detoxification (Altman, Meyer, Mirin, & McNamee, 1976; Meyer, Mirin, Altman, & McNamee, 1976) and maintenance with methadone (Jones & Prada, 1975; Stitzer, McCaul, Bigelow, & Liebson, 1983), buprenorphine (Mello & Mendelson, 1980; Mello, Mendelson, & Kuehnle, 1982), and naltrexone (Altman et al, 1976; Mello, Mendelson, Kuehnle, & Sellers, 1981; Meyer et al, 1976). More recent studies have used various self-administration procedures to expand findings with pharmacotherapies including methadone (Donny, Brasser, Bigelow, Stitzer, & Walsh, 2005) and buprenorphine/naloxone (Comer, Walker, & Collins, 2005).…”