A 71-year-old woman with an intracranial dural-based mesenchymal chondrosarcoma

Vergeer, Rob A; Vink, Robert; Avenarius, Johannes K. A.; Driesse, M.J.

doi:10.1016/j.jocn.2011.08.042

Cited by 12 publications

(11 citation statements)

References 10 publications

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“…There are studies reporting occurrence of intracranial mesenchymal chondrosarcoma from 2 months to 71 years of age; it occurs most frequently between 20 and 30 years, with slight female predominance. 13 Our patient was 18 years old.…”

Section: Discussionmentioning

confidence: 83%

Intracranial Mesenchymal Chondrosarcoma: A Case Report

Agrawal

Gupta

Juneja

et al. 2015

IJNS

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Primary intracranial mesenchymal chondrosarcoma is an extremely rare tumor. We present a case of primary intracranial mesenchymal chondrosarcoma in a young female who presented with headache, loss of vision, and one episode of convulsions associated with nausea and vomiting. MRI brain revealed a large, well-marginated, lobulated, partially calcified, intensely enhancing lesion with a broad dural base in bilateral frontal regions with marked mass effect suggestive of meningioma. Bilateral frontal craniotomy with gross tumor excision was performed. Histopathology revealed mesenchymal chondrosarcoma. Adjuvant radiotherapy was delivered and patient is currently on follow-up. We emphasize that intracranial mesenchymal chondrosarcoma is a rare neoplasm and should be considered in the differential diagnoses of intracranial mass along with meningioma. Treatment of choice is surgery followed by adjuvant radiotherapy. We review the relevant literature and discuss the characteristics of this rare tumor.

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Section: Discussionmentioning

confidence: 83%

Intracranial Mesenchymal Chondrosarcoma: A Case Report

Agrawal

Gupta

Juneja

et al. 2015

IJNS

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“…Sometimes IEMCs demonstrate extremely hypervascular on angiographic images. 3,4 Included in our two cases, the radiological features were mentioned in 30 patients. Six among them were reported to have cystic components, four were highly vascular, and three were hemorrhagic.…”

Section: Discussionmentioning

confidence: 99%

“…Up-to-date, no study could differentiate IEMC from meningioma by radiological scanning studies. IEMCs are misdiagnosed as atypical meningioma, 1,2 hemangiopericytoma, 3 schwannomas, 4 dural-based metastasis, 5 gliomas, or oligodendroglioma. 6 IEMCs vary from hypo-to isointense on T1-WIs with intense heterogeneous enhancement after administering a contrast substance.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 The recommended appropriate management is gross total resection (GTR) followed by radiotherapy; however, IEMCs have a high propensity for neural axis dissemination. [1][2][3][4] IEMCs are reported to be aggressive, quick-growing tumors with high mitotic index properties. 1,2 Therefore, preoperative radiological distinguishing the subtype of chondrosarcoma is essential in managing these patients.…”

Section: Introductionmentioning

confidence: 99%

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Radiological Features of the Intracranial Extraskeletal Mesenchymal Chondrosarcoma: A Report of Two Cases Insight Into the Literature Review

Abdallah¹,

Çınar²

2020

Preprint

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Background: Mesenchymal chondrosarcomas are the most malignant form of chondrosarcomas. They have mostly affected bones. Rarely, these tumors can be intracranial extraskeletal (IEMC) that originates from the meninges or parenchyma. Methods and Materials: We presented two IEMC patients who were treated at our institutions and followed up for the long-term. To understand the radiological features of IEMC, we conducted a systematic literature review for previously reported series and cases of IEMCs. Results: We surgically treated two young males with IEMC initially diagnosed at their age of 18 and 20 years. The patients initially treated with gross total resection (GTR) and GTR followed by radiotherapy, and followed-up for 218 and 73 months, respectively. With both patients, we obtained 83 reported IEMC patients from the literature. Among them, only 30 cases were reported with their radiological MRI details. The mean age of the reported cases was 24.5±16.0 years (2 months–71 years). Female predominance was 54.2%. The mean progression-free and overall survivals were 27.9 and 39.0 months, respectively. Most IEMCs showed a partially calcified mass on roentgenography and a highly vascular mass on angiography. On T1WIs, IEMCs almost show hypo- to isointensity and intense heterogeneous enhancement after administering a contrast substance. On T2WIs, IEMCs show iso- to hyperintensity.Conclusions: IEMCs usually show dural attachment without a net dural tail sign and a well-identified brimmed vascular nodule on TOF-MRA. This nodule appears as a prominent blooming on SWI. TOF-MRA and SWI images can help in the radiological diagnosis of IEMCs.

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“…Primary intracranial chondrosarcomas are rare, representing <0.15% of all intracranial tumors. Most of them arise from underlying precursor cartilaginous or bony lesions of the axial skeleton, and the most common type of intracranial chondrosarcoma is the mesenchymal type [3,4]. Primary intracranial chondrosarcomas may present with radiation sarcoma [5].…”

Section: Introductionmentioning

confidence: 99%

Squash Cytology of a Dural-Based High-Grade Chondrosarcoma May Mimic That of Glioblastoma in the Central Nervous System

Lee

Kim²,

Chung³

et al. 2015

Acta Cytologica

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Background: Intracranial chondrosarcoma is rare, and most cases occur in the skull base. Intradural chondrosarcoma is even rarer. Case: Here, we describe a case of dural chondrosarcoma with a radiation history for nasopharyngeal carcinoma and a radical prostatectomy for prostatic cancer 15 and 8 years earlier, respectively. A 67-year-old man presented with a 3-week memory disturbance and dysarthria. Computed tomography and magnetic resonance images of the brain revealed a dural-based mass in the left temporal area. Under the impression of a glioblastoma, a resection and an intraoperative squash cytology were done. A necrotic dirty background as well as bluish-to-pinkish myxoid stroma were characteristic; the nuclei of highly pleomorphic tumor cells were hyperchromatic to vesicular with an occasional ground-glass appearance. The cytoplasm was of an eosinophilic hyalinized condensed morphology with an occasional granular appearance. Histologically, the lobulated mass was composed of hypercellular lobules of well-differentiated chondrocytes intermixed with anaplastic pleomorphic cells and diagnosed as a conventional grade III chondrosarcoma. These cells were immunoreactive for D2-40, S-100 protein and vimentin. Brain invasion was also found. Conclusion: Albeit rare, dural-based chondrosarcomas should be considered in the differential diagnosis for meningeal tumors, especially in the case of previous radiation therapy.

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A 71-year-old woman with an intracranial dural-based mesenchymal chondrosarcoma

Cited by 12 publications

References 10 publications

Intracranial Mesenchymal Chondrosarcoma: A Case Report

Intracranial Mesenchymal Chondrosarcoma: A Case Report

Radiological Features of the Intracranial Extraskeletal Mesenchymal Chondrosarcoma: A Report of Two Cases Insight Into the Literature Review

Squash Cytology of a Dural-Based High-Grade Chondrosarcoma May Mimic That of Glioblastoma in the Central Nervous System

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