A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change

Razquín, Cristina; Martínéz, J. Alfredo; Martínez-González, M. Á.; Salas‐Salvadó, Jordi; Estruch, Ramón; Marti, Amelia

doi:10.1007/s00394-009-0090-2

Cited by 24 publications

(19 citation statements)

References 49 publications

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“…Carriers of the À11391A variant who had an MUFA intake exceeding the median MUFA intake (that is, X13% of energy intake) had a lower BMI and reduced risk for developing obesity (Warodomwichit et al, 2009); however, this association was not seen in individuals with an MUFA intake less than 13% (Warodomwichit et al, 2009). Similar results were obtained by a Spanish group who wanted to determine the effects of a Mediterranean-style diet on adiponectin SNPs and weight changes over a 3-year period (Razquin et al, 2009). As mentioned previously, the þ 45G/G and þ 276T/T genotypes were associated with higher weight gain over a 3-year period; however, the Mediterranean diet reversed these effects (Razquin et al, 2009).…”

Section: Adiponectin and Dietary Fassupporting

confidence: 63%

“…Similar results were obtained by a Spanish group who wanted to determine the effects of a Mediterranean-style diet on adiponectin SNPs and weight changes over a 3-year period (Razquin et al, 2009). As mentioned previously, the þ 45G/G and þ 276T/T genotypes were associated with higher weight gain over a 3-year period; however, the Mediterranean diet reversed these effects (Razquin et al, 2009). Currently, the mechanisms by which dietary fats affect adiponectin levels are unclear; however, it is hypothesized that it may be through the activation of PPAR-g. FA such as EPA and DHA are ligands for PPAR-g, which subsequently upregulate adiponectin expression and circulating levels (Krey et al, 1997;Maeda et al, 2001).…”

Section: Adiponectin and Dietary Fassupporting

confidence: 55%

“…In addition, it was shown that obese homozygote carriers of the G allele had decreased serum adiponectin levels relative to obese G/T and T/T carriers (Gonzalez-Sanchez et al, 2005). Razquin et al (2009) also showed that another SNP in the adiponectin gene, þ 45T/G (rs2241766), is associated with body weight, in which individuals with the GG genotype gained the most weight over the study period.…”

Section: Genetic Variations Affecting Adiponectin Signallingmentioning

confidence: 99%

“…Further investigation is required to determine whether this association holds true in men, as adiponectin plasma levels differ significantly between men and women (Nishizawa et al, 2002). Conversely, Kondo et al (2002) and Razquin et al (2009) showed a negative association between the þ 276G/T SNP, adiponectin plasma levels and BMI. Homozygotic carriers of the G allele with a high BMI had lower adiponectin plasma levels, whereas homozygotic carriers of the T allele displayed higher weight gain in response to a Mediterranean-style dietary intervention.…”

Section: Genetic Variations Affecting Adiponectin Signallingmentioning

confidence: 99%

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Fatty acid–gene interactions, adipokines and obesity

Stryjecki

Mutch

2011

Eur J Clin Nutr

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It is now recognized that the low-grade inflammation observed with obesity is associated with the development of a wide range of downstream complications. As such, there is considerable interest in elucidating the regulatory mechanisms underlying the production of inflammatory molecules to improve the prevention and treatment of obesity and its co-morbidities. White adipose tissue is no longer considered a passive reservoir for storing lipids, but rather an important organ influencing energy metabolism, insulin sensitivity and inflammation by the secretion of proteins, commonly referred to as adipokines. Dysregulation of several adipokines, such as tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6) and adiponectin, contributes to the low-grade inflammation that is a hallmark of obesity. Evidence now suggests that fatty acids represent a class of molecules that can modulate adipokine production, thereby influencing inflammatory status. Although the precise molecular mechanisms by which dietary fats regulate adipokine production remain unclear, recent findings indicate that diet-gene interactions may have an important role in the transcriptional and secretory regulation of adipokines. Single-nucleotide polymorphisms in the genes encoding TNF-a, IL-6 and adiponectin can modify circulating levels of these adipokines and, subsequently, obesity-related phenotypes. This genetic variation can also alter the influence of dietary fatty acids on adipokine production. Therefore, the current review will show that it is paramount to consider both genetic information and dietary fat intake to unravel the interindividual variability in inflammatory response observed in intervention protocols targeting obesity.

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Section: Adiponectin and Dietary Fassupporting

confidence: 63%

Section: Adiponectin and Dietary Fassupporting

confidence: 55%

Section: Genetic Variations Affecting Adiponectin Signallingmentioning

confidence: 99%

Section: Genetic Variations Affecting Adiponectin Signallingmentioning

confidence: 99%

See 2 more Smart Citations

Fatty acid–gene interactions, adipokines and obesity

Stryjecki

Mutch

2011

Eur J Clin Nutr

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“…In a different experiment, the relationship between the −174G/C polymorphism of the IL6 gene and a Mediterranean-style diet to document body weight changes after 3 years of a diet change in a high cardiovascular risk population was performed by Razquin et al [102]. There were 737 participants involved in this experiment who were aged 55–80 years that were assigned to either a low-fat diet or to a Mediterranean-style diet group with high consumption of virgin olive oil (VOO) or nuts.…”

Section: Criteria To Detect Diabetesmentioning

confidence: 99%

Dynamics of diabetes and obesity: Epidemiological perspective

Boles¹,

Kandimalla

Reddy³

2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

198

119

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The purpose of this review article is to understand the current literature on obesity, diabetes and therapeutic avenues across the world. Diabetes is a chronic lifestyle condition that affects millions of people worldwide and it is a major health concern in our society. Diabetes and obesity are associated with various conditions, including non-modifiable and modifiable risk factors. Early detectable markers are not well established to detect pre-diabetes and as a result, it becomes diabetes. Several published epidemiological studies were assessed and the findings were summarized. Resources from published studies were used to identify criteria used for pre-diabetes, the role of diet in pre-diabetics and potential risks and characteristics associated with pre-diabetes. Preventive strategies are needed to combat diabetes. Individuals diagnosed with pre-diabetes need detailed education, need to fully understand the risk factors and have the ability to manage diabetes. Interventions exist that include chronic disease self-management programs, lifestyle interventions and pharmacological strategies. Obesity plays a large role in causing pre-diabetes and diabetes. Critical analysis of existing epidemiological research data suggests that additional research is needed to determine the efficacy of interventions.

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Reduction in saturated fat intake for cardiovascular disease

Hooper

Martin

Abdelhamid

et al. 2015

Cochrane Database of Systematic Reviews

480

415

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The findings of this updated review are suggestive of a small but potentially important reduction in cardiovascular risk on reduction of saturated fat intake. Replacing the energy from saturated fat with polyunsaturated fat appears to be a useful strategy, and replacement with carbohydrate appears less useful, but effects of replacement with monounsaturated fat were unclear due to inclusion of only one small trial. This effect did not appear to alter by study duration, sex or baseline level of cardiovascular risk. Lifestyle advice to all those at risk of cardiovascular disease and to lower risk population groups should continue to include permanent reduction of dietary saturated fat and partial replacement by unsaturated fats. The ideal type of unsaturated fat is unclear.

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A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change

Abstract: Anthropometric parameters were taken at baseline and after 3-year follow-up, and the genotyping of the -4034A/C, +45T/G and +276 G/T polymorphisms was done.

Cited by 24 publications

References 49 publications

Fatty acid–gene interactions, adipokines and obesity

Fatty acid–gene interactions, adipokines and obesity

Dynamics of diabetes and obesity: Epidemiological perspective

Reduction in saturated fat intake for cardiovascular disease

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