A 10-day sequential therapy: New option for Helicobacter pylori eradication in children

Meta‐analysis: sequential therapy for Helicobacter pylori eradication in children

“…Of the included studies, 10 RCTs met the inclusion criteria . However, only five were full‐text publications; the remaining five trials were published only in abstract form . Except one publication in Chinese that was translated, all trials were published in English.…”

“…In almost all the studies, the standard triple therapy consisted of a PPI (omeprazole or lansoprazole) and two or three antibiotics. In almost all the included trials, clarithromycin was one of the antibiotics used.…”

“…In almost all the included trials, clarithromycin was one of the antibiotics used. In five out of 10 RCTs, the duration of triple therapy was 7 days . In the remaining studies, the duration of triple therapy ranged from 5 days through 10 days to 14 days .…”

“…Except for one RCT, all were two‐armed studies. The sequential therapy consisted of a PPI (omeprazole or lansoprazole) and amoxicillin administered for the first 5 days or 7 days, and then a PPI and two antibiotics administered for the next 5 or 7 days . In one RCT, the time of administration of the PPI was extended to 30 days .…”

Ornidazole-based sequential therapy is not effective in Helicobacter pylori eradication in children

“…Lionetti et al (11) found an overall eradication rate of 82,5% in 40 children. Lerro et al (12) compared sequential therapy to amoxicillin, omeprazole and tinidazole combination therapy in H. pylori eradication. They randomly assigned 50 children into two therapy groups.…”