A 1-Year Study of Brimonidine Twice Daily in Glaucoma and Ocular Hypertension

Brimonidine 0.15% versus apraclonidine 0.5% for prevention of intraocular pressure elevation after anterior segment laser surgery

“…34 Of the 23 patients in the Nd:YAG capsulotomy group, this study confirmed that patients with glaucoma experience a higher incidence of IOP elevations than patients who do not have glaucoma (P Z .002). Because patients were recruited from a university glaucoma clinic, it is unclear whether this study would have higher incidences of IOP elevation than a general ophthalmology clinic.…”

Brimonidine 0.15% versus apraclonidine 0.5% for prevention of intraocular pressure elevation after anterior segment laser surgery

“…34 Of the 23 patients in the Nd:YAG capsulotomy group, this study confirmed that patients with glaucoma experience a higher incidence of IOP elevations than patients who do not have glaucoma (P Z .002). Because patients were recruited from a university glaucoma clinic, it is unclear whether this study would have higher incidences of IOP elevation than a general ophthalmology clinic.…”

Systemic Side Effects of Ophthalmic Drops

“…3 Clonidine also stimulates parasympathetic outflow, and this may contribute to the slowing of heart rate as a consequence of increased vagal tone. 5 Fatigue is consistent with the pharmacologic activity of an alpha-2 agonist with central activity. 4 In adults, systemic adverse events associated with topical use of brimonidine are dry mouth, fatigue/drowsiness, and headache.…”

Delayed hypersensitivity to brimonidine tartrate 0.2% associated with high intraocular pressure

“…It has been reported that this allergic reaction which occurs in 4.8-9% of patients on brimonidine eye drops is usually seen within the first 9 months. 4,8 In our series of patients a much later presentation was seen in four of the six patients. This may be due to the fact that the studies reporting the delayed hypersensitivity reaction were followed up for 12 months.…”

Brimonidine 0.15% versus apraclonidine 0.5% for prevention of intraocular pressure elevation after anterior segment laser surgery

“…34 Of the 23 patients in the Nd:YAG capsulotomy group, this study confirmed that patients with glaucoma experience a higher incidence of IOP elevations than patients who do not have glaucoma (P Z .002). Because patients were recruited from a university glaucoma clinic, it is unclear whether this study would have higher incidences of IOP elevation than a general ophthalmology clinic.…”

Systemic Side Effects of Ophthalmic Drops

“…3 Clonidine also stimulates parasympathetic outflow, and this may contribute to the slowing of heart rate as a consequence of increased vagal tone. 5 Fatigue is consistent with the pharmacologic activity of an alpha-2 agonist with central activity. 4 In adults, systemic adverse events associated with topical use of brimonidine are dry mouth, fatigue/drowsiness, and headache.…”

Delayed hypersensitivity to brimonidine tartrate 0.2% associated with high intraocular pressure

“…It has been reported that this allergic reaction which occurs in 4.8-9% of patients on brimonidine eye drops is usually seen within the first 9 months. 4,8 In our series of patients a much later presentation was seen in four of the six patients. This may be due to the fact that the studies reporting the delayed hypersensitivity reaction were followed up for 12 months.…”

Brimonidine 0.15% versus apraclonidine 0.5% for prevention of intraocular pressure elevation after anterior segment laser surgery

“…34 Of the 23 patients in the Nd:YAG capsulotomy group, this study confirmed that patients with glaucoma experience a higher incidence of IOP elevations than patients who do not have glaucoma (P Z .002). Because patients were recruited from a university glaucoma clinic, it is unclear whether this study would have higher incidences of IOP elevation than a general ophthalmology clinic.…”

Systemic Side Effects of Ophthalmic Drops

“…3 Clonidine also stimulates parasympathetic outflow, and this may contribute to the slowing of heart rate as a consequence of increased vagal tone. 5 Fatigue is consistent with the pharmacologic activity of an alpha-2 agonist with central activity. 4 In adults, systemic adverse events associated with topical use of brimonidine are dry mouth, fatigue/drowsiness, and headache.…”

Delayed hypersensitivity to brimonidine tartrate 0.2% associated with high intraocular pressure

“…It has been reported that this allergic reaction which occurs in 4.8-9% of patients on brimonidine eye drops is usually seen within the first 9 months. 4,8 In our series of patients a much later presentation was seen in four of the six patients. This may be due to the fact that the studies reporting the delayed hypersensitivity reaction were followed up for 12 months.…”