Abstract:The present study was undertaken to investigate the hepatotoxic potential of rosiglitazone-an oral hypoglycemic thiazolidenedione class of drug. The hepatotoxic potential of rosiglitazone was assessed in-vitro on isolated rat hepatocytes before subjecting to in-vivo studies. The in-vitro activity was measured by trypan blue exclusion assay and determination of liver marker enzymes. The hepatotoxic potential of rosiglitazone was measured at 100 to 500 µg/ml concentration and maximum hepatotoxicity was produced … Show more
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