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doi:10.1001/archderm.126.11.1523

Cited by 26 publications

(5 citation statements)

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“…BMT has been associated with transfer of immune-mediated diseases to recipients including autoimmune thyroiditis [25], psoriasis [26], insulin-dependent diabetes [27] and immune cytopenia [28]. In the literature adoptive passive transfer of vitiligo from the donor to the recipient after BMT has been reported [7, 9].…”

Section: Discussionmentioning

confidence: 99%

Vitiligo after Hematopoietic Cell Transplantation: Six Cases and Review of the Literature

et al. 2008

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Aim: To investigate the prevalence and clinical characteristics of vitiligo after allogeneic hematopoietic cell transplantation (AHCT). Methods: The development of vitiligo was analyzed among 421 patients who underwent AHCT in Ibni Sina Hospital (University of Ankara) between 1988 and 2004. Results: Among 421 patients, we describe 6 with generalized vitiligo occurring after AHCT for chronic myelogenous leukemia. Five of them had severe chronic graft-versus-host disease (GVHD). Vitiligo was accompanied by alopecia areata and acquired ichthyosis in 2 patients with GVHD. Conclusion: Melanocyte destruction caused by the autoimmune reactions triggered by chronic GVHD as well as a genetic predisposition might have played a role in the development of vitiligo in our patients. These data support the hypothesis that vitiligo is an autoimmune entity.

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Section: Discussionmentioning

confidence: 99%

Vitiligo after Hematopoietic Cell Transplantation: Six Cases and Review of the Literature

et al. 2008

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“…Two cases that developed psoriasis after HSCT have been reported [6, 7]. In one case, the donor of allogeneic HSCT had a history of psoriasis [6].…”

Section: Discussionmentioning

confidence: 99%

“…Two cases that developed psoriasis after HSCT have been reported [6, 7]. In one case, the donor of allogeneic HSCT had a history of psoriasis [6]. In another case, psoriasis was found after syngeneic HSCT from a twin donor with a history of psoriasis vulgaris [7].…”

Section: Discussionmentioning

confidence: 99%

“…Both previous cases had an apparent psoriatic history of the donor. In the former case, the psoriasiform eruption was transiently induced on day 175 after HSCT [6], but then the eruption disappeared with topical therapy by day 196 after HSCT. In the latter case, the psoriasiform eruption was induced on day 10 after HSCT and persisted for 8 years [7].…”

Section: Discussionmentioning

confidence: 99%

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A Case of Acute Cutaneous Graft-versus-Host Disease Mimicking Psoriasis Vulgaris

Matsushita¹,

Hasegawa²,

Shirasaki³

et al. 2007

Dermatology

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Graft-versus-host disease (GVHD) is a frequent complication occurring after allogenic hematopoietic stem cell transplantation and is divided into acute and chronic type. Cutaneous involvement is the most frequent manifestation of acute GVHD, with maculopapular exanthema and perifollicular papular lesions. We describe the first case to develop acute cutaneous GVHD mimicking psoriasis vulgaris shortly after allogenic peripheral blood stem cell transplantation. The patient’s rash resembled psoriasis vulgaris and showed histologic features of both psoriasis and acute GVHD. Despite various immunosuppressant therapies, the skin lesion was drug-resistant. Therefore, we administered psoralen-UVA (PUVA) therapy and achieved the desired therapeutic effect. As far as we know, this is the first case of psoriasiform skin eruption as a manifestation of acute GVHD.

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“…However, it is widely accepted that a dysregulation of the immune system by an alteration in the cytokine production provides persistent proinflammatory signals in the skin that lead to psoriatic lesions. This is also supported by the fact that psoriasis may be cured by allogenic bone marrow transplantation [8] and that psoriasis may be transferred from the bone marrow transplant donor to the recipient [9]. Although a model involving dysregulated cytokines is conceptually useful and therapeutically relevant, it does not entail the full complexity of the disease or the more than 1,300 genes that are differentially expressed in psoriatic lesions [10].…”

Section: Introductionmentioning

confidence: 99%

Regulation of cytokines by small RNAs during skin inflammation

Bak

Mikkelsen

2010

J Biomed Sci

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Intercellular signaling by cytokines is a vital feature of the innate immune system. In skin, an inflammatory response is mediated by cytokines and an entwined network of cellular communication between T-cells and epidermal keratinocytes. Dysregulated cytokine production, orchestrated by activated T-cells homing to the skin, is believed to be the main cause of psoriasis, a common inflammatory skin disorder. Cytokines are heavily regulated at the transcriptional level, but emerging evidence suggests that regulatory mechanisms that operate after transcription play a key role in balancing the production of cytokines. Herein, we review the nature of cytokine signaling in psoriasis with particular emphasis on regulation by mRNA destabilizing elements and the potential targeting of cytokine-encoding mRNAs by miRNAs. The proposed linkage between mRNA decay mediated by AU-rich elements and miRNA association is described and discussed as a possible general feature of cytokine regulation in skin. Moreover, we describe the latest attempts to therapeutically target cytokines at the RNA level in psoriasis by exploiting the cellular RNA interference machinery. The applicability of cytokine-encoding mRNAs as future clinical drug targets is evaluated, and advances and obstacles related to topical administration of RNA-based drugs targeting the cytokine circuit in psoriasis are described.

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Cited by 26 publications

References 0 publications

Vitiligo after Hematopoietic Cell Transplantation: Six Cases and Review of the Literature

Vitiligo after Hematopoietic Cell Transplantation: Six Cases and Review of the Literature

A Case of Acute Cutaneous Graft-versus-Host Disease Mimicking Psoriasis Vulgaris

Regulation of cytokines by small RNAs during skin inflammation

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