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Deliveliotis, Ch.; Varkarakis, John; Trakas, N.; Louras, G.; Giannakopoulos, Stilianos; Skolarikos, Andreas; Alargof, E.

doi:10.1023/a:1007128008153

Cited by 8 publications

(1 citation statement)

References 15 publications

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“…Seminal vesicle invasion is an insufficient prognostic parameter with biochemical progression- free rates varying between 5–60% [ 42 , 43 ]. Bloom et al showed the relation between SVI and post radical prostatectomy high BCR levels which later developed distant metastasis [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Predictive factors for biochemical recurrence in radical prostatectomy patients

Türk

Çelik

Ün

et al. 2015

CEJU

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IntroductionRadical prostatectomy (RP) is considered the best treatment for the management of localized prostate cancer in patients with life expectancy over 10 years. However, a complete recovery is not guaranteed for all patients who received/underwent RP treatment. Biochemical recurrence is frequently observed during the post-operative follow-up period. The main objective in this study is to evaluate the predictive factors of biochemical recurrence in localized prostate cancer patients who underwent RP surgeryMaterial and methodsThe study included 352 patients with prostate cancer treated by RP at a single institution between February 2004 and June 2014. Detailed pathological and follow-up data of all patients were obtained and analyzed to determine the results.ResultsMean follow-up duration was 39.7 months. 83 patients (23%) experienced biochemical recurrence (BCR) during the follow-up period. Mean BCR duration range was 6.56 (1–41) months. In multivariate logistic regression analysis, Gleason score (GS), PSA and extra-capsular tumour spread (ECS) variables were found to be statistically significant as BCR predictive factors.ConclusionsAccording to our study results, it is thought that PSA, GS and ECS can all be used for guidance in choosing a treatment modality for post-RP biochemical recurrence and metastatic disease as predictive factors. However, there is no consensus in this matter and it is still debated.

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Section: Discussionmentioning

confidence: 99%