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Yegorov, Yegor E.; Veiko, Natalia N.; Tsvetkova, T. G.; Terekhov, S. M.; Karachentsev, Dmitry; Vishnyakova, Khava S.; Смирнова, Т. Д.; Lyapunova, N. A.; Zelenin, A. V.

doi:10.1023/a:1020784200611

Cited by 1 publication

(2 citation statements)

References 8 publications

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“…There are definite (and rather similar) relations between telomeres, telomerase, and nucleoli [201]. Thus, RNA of human telomerase contains the sequences responsible for transport into the nucleolus [202].…”

Section: Centriolar/cytoskeletal Mechanisms Of Cell Replicative Agingmentioning

confidence: 99%

“…A syn drome is described when mutation in the protein diskerin (a normal nucleolar component) results in a sharp decrease in the telomerase activity, possibly, at the cost of enhanced interaction of diskerin with RNA of telomerase [203]. There are hypotheses that connect cell aging and the nucleolus: the nucleolus can be the place of accumu lation of telomere binding proteins [201,204]. It is also known that factors directly influencing the assemblage of nucleoli are located in the centrosome during mitosis.…”

Section: Centriolar/cytoskeletal Mechanisms Of Cell Replicative Agingmentioning

confidence: 99%

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Centriolar Mechanisms of Differentiation and Replicative Aging of Higher Animal Cells

Tkemaladze¹,

Chichinadze

2005

Biochemistry (Moscow)

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The centrosome (centriole) and the cytoskeleton produced by it are structures, which probably determine differentiation, morphogenesis, and switching on the mechanism of replicative aging in all somatic cells of multicellular animals. The mechanism of such programming of the events seems to include cytoskeleton influences and small RNAs related to the centrosome. 1) If these functions are really related with centrioles, the multicellular organism's cells which: a) initially lack centrioles (e.g., higher plant cells and also zygote and early blastomeres of some animals) or cytoskeleton (e.g., embryonic stem cells); or b) generate centrioles de novo (e.g., zygote and early blastomeres of some animals), will be totipotent and lack replicative aging. Consequently, the absence (constant or temporary) of the structure determining the counting of divisions also means the absence of counting of differentiation processes. 2) Although a particular damage to centrioles or cytoskeleton (e.g., in tumor cells) fails to make the cells totipotent (because the morphogenetic status of these cells, as differentiated from that of totipotent ones, is not zero), but such a transformation can suppress the initiation of the aging mechanism induced by these structures and, thus, make such cells replicatively "immortal".

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Section: Centriolar/cytoskeletal Mechanisms Of Cell Replicative Agingmentioning

confidence: 99%

Section: Centriolar/cytoskeletal Mechanisms Of Cell Replicative Agingmentioning

confidence: 99%

Centriolar Mechanisms of Differentiation and Replicative Aging of Higher Animal Cells

Tkemaladze¹,

Chichinadze

2005

Biochemistry (Moscow)

View full text Add to dashboard Cite

show abstract

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Cited by 1 publication

References 8 publications

Centriolar Mechanisms of Differentiation and Replicative Aging of Higher Animal Cells

Centriolar Mechanisms of Differentiation and Replicative Aging of Higher Animal Cells

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