99mTc-TRODAT-1 SPECT/CT imaging as a complementary biomarker in the diagnosis of parkinsonian syndromes

Mittal, Bhagwant Rai; Sood, Apurva; Shukla, Jaya; Vatsa, Rakhee; Bhusari, Priya; Shree, Ritu; Mehta, Sahil; Goyal, Manoj; Modi, Manish

doi:10.1097/mnm.0000000000000802

Cited by 12 publications

(21 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, algorithms for image reconstruction and sophisticated compensation techniques to correct for photon attenuation and scattering have made quantitative SPECT viable in a manner similar to quantitative PET (i.e., kBqcm -3 , SUV) [18,19].…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of SPECT/CT scans using SUV measurement of the normal pelvis with Tc-99m methylene diphosphonate

Wang

Duan

Shen

et al. 2018

Int J Radiol Radiat Oncol

View full text Add to dashboard Cite

et al. (2018) A retrospective study of SPECT/CT scans using SUV measurement of the normal pelvis with Tc-99m methylene diphosphonate. Int J Radiol Radiat Oncol 4(1): 003-008. DOI: http://dx. AbstractObjective: This study aimed to perform the quantitative measurement based on the standardized uptake value (SUV) of Tc-99m methylene diphosphonate (MDP) in normal pelvis using a single-photon emission tomography (SPECT)/computed tomography (CT) scanner. Material and Methods:This retrospective study was performed on 31 patients with cancer undergoing bone SPECT/CT scans with 99m Tc-MDP between August and December 2016. SUV max and SUV mean of the normal pelvis were calculated based on the body weight. SUV max and SUV mean of the bilateral anterior superior iliac spine, posterior superior iliac spine, facies auricularis ossis ilii, ischial tuberosity, and sacrum were calculated. Further, the correlation of SUV max and SUV mean of all parts of the pelvis with weight, height, and CT was studied. Results:The data for 31 patients (20 women and 11 men; mean age 58.97± 9.12 years; age range 37-87 years) were acquired. SUV max and SUV mean changed from 1.65 ± 0.40 to 3.8 ± 1 and from 1.15 ± 0.25 to 2.07 ± 0.58, respectively. The coeffi cient of variation of SUV max and SUV mean ranged from 0.22 to 0.31. SUV max and SUV mean had no statistically signifi cant difference between men and women. SUV max and SUV mean showed no signifi cant correlation with weight and height. Part of SUV max and SUV mean showed a signifi cant correlation with CT. However, SUV max and SUV mean of bilateral ischial tuberosity showed a signifi cant correlation with CT values. Conclusions:SUVs of the normal pelvis showed a relatively large variability. As a quantitative imaging biomarker, SUVs might require standardization with adequate reference data for the participant to minimize variability.

show abstract

Section: Discussionmentioning

confidence: 99%

A retrospective study of SPECT/CT scans using SUV measurement of the normal pelvis with Tc-99m methylene diphosphonate

Wang

Duan

Shen

et al. 2018

Int J Radiol Radiat Oncol

View full text Add to dashboard Cite

show abstract

“…With regards to the differential diagnosis between PD and atypical parkinsonian syndromes, studies that compare the two modalities are not available. Although at group level, a more uniform involvement of the striatum has been reported in patients with progressive supranuclear palsy, no reliable distinctive patterns of DAT decline make it possible to individually discriminate patients with atypical parkinsonian syndromes from PD [25][26][27].…”

Section: Diagnostic Accuracymentioning

confidence: 99%

Dopamine transporter imaging in neurodegenerative movement disorders: PET vs. SPECT

Kerstens

Varrone

2020

Clin Transl Imaging

View full text Add to dashboard Cite

Purpose The dopamine transporter (DAT) serves as biomarker for parkinsonian syndromes. DAT can be measured in vivo with single-photon emission computed tomography (SPECT) and positron emission tomography (PET). DAT-SPECT is the current clinical molecular imaging standard. However, PET has advantages over SPECT measurements, and PET radioligands with the necessary properties for clinical applications are on the rise. Therefore, it is time to review the role of DAT imaging with SPECT compared to PET. Methods PubMed and Web of Science were searched for relevant literature of the previous 10 years. Four topics for comparison were used: diagnostic accuracy, quantitative accuracy, logistics, and flexibility. Results There are a few studies directly comparing DAT-PET and DAT-SPECT. PET and SPECT both perform well in discriminating neurodegenerative from non-neurodegenerative parkinsonism. Clinical DAT-PET imaging seems feasible only recently, thanks to simplified DAT assessments and better availability of PET radioligands and systems. The higher resolution of PET makes more comprehensive assessments of disease progression in the basal ganglia possible. Additionally, it has the possibility of multimodal target assessment. Conclusion DAT-SPECT is established for differentiating degenerative from non-degenerative parkinsonism. For further differentiation within neurodegenerative Parkinsonian syndromes, DAT-PET has essential benefits. Nowadays, because of wider availability of PET systems and radioligand production centers, and the possibility to use simplified quantification methods, DAT-PET imaging is feasible for clinical use. Therefore, DAT-PET needs to be considered for a more active role in the clinic to take a step forward to a more comprehensive understanding and assessment of Parkinson’s disease.

show abstract

“…Nonetheless, when comparison to age-matched healthy controls is required, such as the examination of the dopamine transporters with 123 I-FP CIT in cases of parkinsonism (Fig. 11), CT information helps to obtain a more robust spatial normalization of SPECT data [232][233][234]. The use of SPECT/CT in brain tumours with tracers such as 99m Tc-MIBI and 99m Tc-tetrofosmin (Myoview ® ) or 99m Tc-bis-methionine-DTPA (MDM) is limited and largely restricted to differentiation between recurrence and radiation necrosis [235].…”

Section: Neurologymentioning

confidence: 99%

Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence

Israel

Pellet

Biassoni

et al. 2019

Eur J Nucl Med Mol Imaging

161

View full text Add to dashboard Cite

Purpose Single-photon emission computed tomography (SPECT) combined with computed tomography (CT) was introduced as a hybrid SPECT/CT imaging modality two decades ago. The main advantage of SPECT/CT is the increased specificity achieved through a more precise localization and characterization of functional findings. The improved diagnostic accuracy is also associated with greater diagnostic confidence and better inter-specialty communication. Methods This review presents a critical assessment of the relevant literature published so far on the role of SPECT/CT in a variety of clinical conditions. It also includes an update on the established evidence demonstrating both the advantages and limitations of this modality. Conclusions For the majority of applications, SPECT/CT should be a routine imaging technique, fully integrated into the clinical decision-making process, including oncology, endocrinology, orthopaedics, paediatrics, and cardiology. Large-scale prospective studies are lacking, however, on the use of SPECT/CT in certain clinical domains such as neurology and lung disorders. The review also presents data on the complementary role of SPECT/CT with other imaging modalities and a comparative analysis, where available.

show abstract

99mTc-TRODAT-1 SPECT/CT imaging as a complementary biomarker in the diagnosis of parkinsonian syndromes

Abstract: For clinical practice, both the visual analysis and the quantitative parameters of Tc-TRODAT-1 single-photon emission computed tomography/computed tomography showed usefulness in distinguishing cases of PD and PPS from the healthy individuals.

Cited by 12 publications

References 22 publications

A retrospective study of SPECT/CT scans using SUV measurement of the normal pelvis with Tc-99m methylene diphosphonate

A retrospective study of SPECT/CT scans using SUV measurement of the normal pelvis with Tc-99m methylene diphosphonate

Dopamine transporter imaging in neurodegenerative movement disorders: PET vs. SPECT

Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence

Contact Info

Product

Resources

About