980 nm and 808 nm excitable upconversion nanoparticles for the detection of enzyme related reactions

Himmelstoß, Sandy F.; Wiesholler, Lisa M.; Buchner, Markus; Muhr, Verena; Märkl, Susanne; Baeumner, Antje J.; Hirsch, Thomas

doi:10.1117/12.2252381

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Abundant energy states of lanthanide-based ions endow the upconversion nanoparticles with enormous chances for the up-energy transfer processes. These complex energy transfer systems can be divided into three processes: the excited-state absorption (ESA), energy transfer upconversion (ETU), and photon avalanche (PA) [ 56 – 58 ]. The fluorescence mechanism of UCNPs based on the principle of the two-photon or multiphoton process of UCL is illustrated in Fig.…”

Section: The Fundamentals Of Ucnp Compositionmentioning

confidence: 99%

Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment

et al. 2020

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Multifunctional lanthanide-based upconversion nanoparticles (UCNPs), which feature efficiently convert low-energy photons into high-energy photons, have attracted considerable attention in the domain of materials science and biomedical applications. Due to their unique photophysical properties, including light-emitting stability, excellent upconversion luminescence efficiency, low autofluorescence, and high detection sensitivity, and high penetration depth in samples, UCNPs have been widely applied in biomedical applications, such as biosensing, imaging and theranostics. In this review, we briefly introduced the major components of UCNPs and the luminescence mechanism. Then, we compared several common design synthesis strategies and presented their advantages and disadvantages. Several examples of the functionalization of UCNPs were given. Next, we detailed their biological applications in bioimaging and disease treatment, particularly drug delivery and photodynamic therapy, including antibacterial photodynamic therapy. Finally, the future practical applications in materials science and biomedical fields, as well as the remaining challenges to UCNPs application, were described. This review provides useful practical information and insights for the research on and application of UCNPs in the field of cancer.

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Section: The Fundamentals Of Ucnp Compositionmentioning

confidence: 99%

Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment

et al. 2020

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“…This inconvenience can be overcome by doping UCNPs with neodymium ions lowering the excitation wavelength to 808 nm. Sample heating can thus be avoided which is of particular importance for in vivo bioimaging [ 46 ] and this approach also shows advantages in the monitoring of enzymatic reactions [ 47 ].…”

Section: Nanoparticlesmentioning

confidence: 99%

Synergetic Effects of Combined Nanomaterials for Biosensing Applications

Holzinger

Goff

Cosnier

2017

Sensors

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Nanomaterials have become essential components for the development of biosensors since such nanosized compounds were shown to clearly increase the analytical performance. The improvements are mainly related to an increased surface area, thus providing an enhanced accessibility for the analyte, the compound to be detected, to the receptor unit, the sensing element. Nanomaterials can also add value to biosensor devices due to their intrinsic physical or chemical properties and can even act as transducers for the signal capture. Among the vast amount of examples where nanomaterials demonstrate their superiority to bulk materials, the combination of different nano-objects with different characteristics can create phenomena which contribute to new or improved signal capture setups. These phenomena and their utility in biosensor devices are summarized in a non-exhaustive way where the principles behind these synergetic effects are emphasized.

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980 nm and 808 nm excitable upconversion nanoparticles for the detection of enzyme related reactions

Cited by 2 publications

References 17 publications

Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment

Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment

Synergetic Effects of Combined Nanomaterials for Biosensing Applications

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