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“…Shionogi researchers also studied 9-oxime analogues in detail [66]. A series of C11-C12 cyclic analogues (Fig.…”
Section: Novel Analogues With Other Structural Featuresmentioning
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“…Shionogi researchers also studied 9-oxime analogues in detail [66]. A series of C11-C12 cyclic analogues (Fig.…”
Section: Novel Analogues With Other Structural Featuresmentioning
“…From the 11,12-carbamate ketolides or from the 11,12-carbonate ketolides a C9 oximation reaction was undertaken to give rise to the 9-oxime ketolides. The latter, in particular those of the 11,12-carbonate ketolides series (Figure 21) with compound 27 [184] exhibited better activity both on sensitive and resistant strains than other macrolides including Staphylococcus aureus resistant to Erythromycin by a constitutive MLSB mechanism [184]- [190]. However, the activity although being more stable in gastric acid medium, compound 27 has proved to be ineffective against S. pneumoniae resistant to Erythromycin [184].…”
Section: ) Oxime Ketolidesmentioning
“…13 To develop novel potent ketolides, a variety of structural modifications of the ketolide core skeleton have been carried out. Recently, many ketolide derivatives such as 6-O-alkyl ketolides, [14][15][16][17][18][19] 9-oxime macrolides, [20][21][22][23][24][25] 11,12-cyclic carbamate ketolides, [26][27][28][29][30][31][32] 13-substituents ketolides and 6,11-bridged ketolides [33][34][35] with excellent activities toward numerous macrolide-resistant pathogens were obtained. Herein, we described the synthesis and in vitro biological evaluation of a set of novel ketolides bearing an aryltetrazolyl-substituted alkyl side chain.…”
Section: Introductionmentioning