7B.09

Huang, Qi‐Fang; Li, Y.; Sheng, Chunhong; Dou, Yu; Zheng, Mingqi; Zhu, Zhiming; Wang, J.

doi:10.1097/01.hjh.0000467606.23483.a4

Cited by 7 publications

(4 citation statements)

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“…1,4-DHPs are considered one of the most useful molecular scaffolds in medicinal chemistry. The scaffold is the main constituent of several crucial drugs, including amlodipine and nifedipine [ 24 ]. The structure of 1,4-DHP resembles the coenzyme NADH, which is very important in oxidation and reduction reactions in biological systems.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of C5–C6-unsubstituted 1,4-DHP scaffolds using an efficient Ni–chitosan nanocatalyst under ultrasonic conditions

Basu¹,

Chatterjee²,

Ray³

et al. 2022

Beilstein J. Org. Chem.

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A heterogeneous and magnetically recyclable Ni–chitosan nanocatalyst was synthesized and thoroughly characterized by powder Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) analysis, scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray (EDX) spectroscopy, etc. It was effectively utilized in the eco-friendly synthesis of new C5–C6-unsubstituted 1,4-DHPs under ultrasonic irradiation. The important focus of the methodology was to develop an environmentally friendly protocol with a short reaction time and a simple reaction procedure. The other advantages of this protocol are a wide substrate scope, a very good product yield, the use of an eco-friendly solvent and a recyclable nanocatalyst, as well as reaction at room temperature.

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Section: Introductionmentioning

confidence: 99%

Green synthesis of C5–C6-unsubstituted 1,4-DHP scaffolds using an efficient Ni–chitosan nanocatalyst under ultrasonic conditions

Basu¹,

Chatterjee²,

Ray³

et al. 2022

Beilstein J. Org. Chem.

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“…Among the aza‐heterocyclic compounds, pyridocarbazoles are critical scaﬀolds that have received considerable attention due to their broad spectrum of biological properties [7–9] . Dihydropyridines (DHPs) are organic scaffolds based on pyridine nucleus, they exhibit intriguing biological functions, [10] and it has served as a vital drugs in treatment of angina and hypertension [11] . The greatest interest of this class can be explained by their activity as calcium channel blockers for the treatment of cardiovascular disease [12]…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9] Dihydropyridines (DHPs) are organic scaffolds based on pyridine nucleus, they exhibit intriguing biological functions, [10] and it has served as a vital drugs in treatment of angina and hypertension. [11] The greatest interest of this class can be explained by their activity as calcium channel blockers for the treatment of cardiovascular disease. [12] Synthetic efforts for preparing aza heterocyclic scaffolds like pyridine and dihydropyridine, have been continuously devoted in the past few years.…”

Section: Introductionmentioning

confidence: 99%

A Direct and Divergent Entrance to Aza Heterocycles On 3‐Amino Carbazole

Murali

Prasad

2022

ChemistrySelect

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The product‐switchable reagent‐controlled construction of 1,4‐Dihydropyridines and stereo‐structured amino dienes decorated with carbazole moieties have been realized via coupling of 3‐amino‐9‐ethylcarbazole with benzaldehyde and methyl propiolate. Highly functionalized pyrido[3,2‐b]carbazoles have been concisely synthesized in good yields via Et3N promoted single‐pot assembly of 3‐amino‐9‐ethylcarbazole with aryl/heteroaryl aldehydes and α‐aryl‐3‐oxopropanenitrile. The structures of the synthesized products were confirmed by spectral data and elemental analysis.

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“…The 1,4-DHP scaffold has served as a nucleus for several blockbuster drugs such as nifedipine and amlodipine. 1 Close resemblance to nicotinamine adenine dinucleotide (NADH) coenzyme, which has an important role in biological oxidation-reduction reactions, has made the 1,4-DHP core even more lucrative. Perhaps less studied in the past, the potential of 1,2-dihydropyridines has recently been explored as a critical scaffold for the synthesis of alkaloids and other drugs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, utility and medicinal importance of 1,2- & 1,4-dihydropyridines

2017

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Dihydropyridine (DHP) is among the most beneficial scaffolds that have revolutionised pharmaceutical research with unprecedented biological properties. Over the years, metamorphosis of easily accessible 1,2-and 1,4-dihydropyridine (1,4-DHP) intermediates by synthetic chemists has generated several drug molecules and natural products such as alkaloids. The 1,4-dihydropyridine (1,4-DHP) moiety itself is the main fulcrum of several approved drugs. The present review aims to collate the literature of 1,2-and the 1,4-DHPs relevant to synthetic and medicinal chemists. We will describe various methodologies that have been used for the synthesis of this class of compounds, including the strategies which can furnish enantiopure DHPs, either by asymmetric synthesis or by chiral resolution.We will also elaborate the significance of DHPs towards the synthesis of natural products of medicinal merit.

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7B.09

Cited by 7 publications

References 0 publications

Green synthesis of C5–C6-unsubstituted 1,4-DHP scaffolds using an efficient Ni–chitosan nanocatalyst under ultrasonic conditions

Green synthesis of C5–C6-unsubstituted 1,4-DHP scaffolds using an efficient Ni–chitosan nanocatalyst under ultrasonic conditions

A Direct and Divergent Entrance to Aza Heterocycles On 3‐Amino Carbazole

Synthesis, utility and medicinal importance of 1,2- & 1,4-dihydropyridines

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