78Gy with Fiducial Marker Image‐Guided Radiotherapy in Prostate Cancer: Single Center Analysis of 301 Patients

Choong, Ee Siang; Hruby, George; Yang, Yee Hwa; Kwong, Carol; Patanjali, Nitya

doi:10.1111/ajco.12637

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…Other Australian series which have used higher doses have shown similar results at the 5‐year mark. Choong et al . reported on a cohort of 301 Australian patients treated with doses of 78 Gy with fiducial marker image‐guided radiotherapy and found a 4‐year freedom from biochemical failure rate of 88.8%.…”

Section: Discussionmentioning

confidence: 99%

Long‐term outcomes in 1121 Australian prostate cancer patients treated with definitive radiotherapy

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Long‐term outcomes in 1121 Australian prostate cancer patients treated with definitive radiotherapy

et al. 2018

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“…The use of different fiducials with portal imaging or CBCT is well established in clinical routine [1,11]. However, the combination of MRI planning and the use of GMs in regard to visibility on MRI [12,13], distortion of MRI data by artifacts [14] and anisotropic deformation of MRI-sequences [15] with underestimated prostatic volumes (target miss) are currently under investigation.…”

Section: Introductionmentioning

confidence: 99%

Precision of T2 TSE MRI-CT-image fusions based on gold fiducials and repetitive T2 TSE MRI-MRI-fusions for adaptive IGRT of prostate cancer by using phantom and patient data

et al. 2018

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2019) Precision of T2 TSE MRI-CT-image fusions based on gold fiducials and repetitive T2 TSE MRI-MRI-fusions for adaptive IGRT of prostate cancer by using phantom and patient data, Acta Oncologica, 58:1, 88-94, ABSTRACT Introduction: To increase precision of radiation treatment (RT) delivery in prostate cancer, MRI-based RT as well as the use of fiducials like gold markers (GMs) have shown promising results. Their combined use is currently under investigation in clinical trials. Here, we aimed to evaluate a workflow of image registration based on GMs between CT and MRI as well as weekly MRI-MRI adaption based on T2 TSE sequence. Material and methods: A gel-phantom with two inserted GMs was scanned with CT and three different MR-scanners of 1.5 and 3 T (T2 TSE and T1 VIBE-Dixon, isotropic, voxel size 2 Â 2 Â 2 mm). After image fusion, deviations for fiducial and gel match were measured and artifacts were evaluated. Additionally, CT-MRI-match deviations and MRI-MRI-match deviations of 10 Patients from the M-basePro study using GMs were assessed. Results: GMs were visible in all imaging modalities. The outer gel contours were matched with <1 mm deviation, contour volumes varied between 0 and 1%. The deviations of the GMs were less than 2 mm in any direction of MRI/CT. Shifts of peripherally or centrally located GMs were randomly distributed. The average MRI-CT-match precision of 10 patients with GMs was 1.9 mm (range 1.1-3.1 mm). Conclusions: Match inaccuracies for GMs between reference CT and voxel-isotropic T2-TSE sequences are small. Spatial deviations of CT-and MR-contoured fiducials were less than 2 mm, i.e., below SLT of the applied modalities. In patients, the average CT-MRI-match precision for GMs was 1.9 mm supporting their use in MR-guided high precision RT. ARTICLE HISTORY

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“…Acute GU toxicity of Grade 1 was observed in 62% and Grade 2 in 21% and GI toxicity in 29% and 11% respectively. Whereas Grade 3 was described in 1% of treated individuals [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Does the radiation approach affects acute toxicity in prostate cancer patients? A comparison of four radiation techniques

Poźniak-Balicka

Chomiak

Wośkowiak

et al. 2020

Cent european J Urol

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Introduction Prostate cancer is treated with increasingly sophisticated radiation techniques. The aim of the study is to compare acute toxicity in patients managed with different therapeutic modalities. Material and methods A total of 60 patients irradiated between 2012 and 2016 were analyzed: A. conformal 3D – 11, B. intensity-modulated radiation therapy (IMRT) 20, C. image-guided radiation therapy (IGRT) – 19 and D. volumetric modulated arc therapy (VMAT) – 10. Patients' age ranged from 46 to 85 years (median 70.5), prostate-specific antigen values at the time of diagnosis were in the range of 3.54–154 ng/ml (median 15.9). Acute toxicity from the genitourinary (GU) and gastrointestinal (GI) tracts according to the European Organization for Research and Treatment of Cancer (EORTC) /Radiation Therapy Oncology Group (RTOG) grading system were assessed. Results All irradiation techniques were well tolerated and neither 3 nor 4 degrees acute toxicity was observed. Importantly, IGRT and IMRT did not lead to Grade 2 GI acute toxicity. There was no relationship between the severity of GU acute toxicity depending on the irradiation technique used (p = 0.8), but a trend towards a significant relationship was noted for GI acute toxicity (p = 0.05). Conclusions All assessed irradiation methods do not lead to severe acute adverse effects. Importantly, patients treated with IGRT and IMRT had only minor GI toxicity.

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78Gy with Fiducial Marker Image‐Guided Radiotherapy in Prostate Cancer: Single Center Analysis of 301 Patients

Abstract: Dose escalation to 78Gy with FMIGRT in our series achieved good FFBF at 5 years with low acute and late toxicity rates. These results provide a good comparator cohort to our current use of image-guided intensity modulated radiotherapy.

Cited by 4 publications

References 30 publications

Long‐term outcomes in 1121 Australian prostate cancer patients treated with definitive radiotherapy

Long‐term outcomes in 1121 Australian prostate cancer patients treated with definitive radiotherapy

Precision of T2 TSE MRI-CT-image fusions based on gold fiducials and repetitive T2 TSE MRI-MRI-fusions for adaptive IGRT of prostate cancer by using phantom and patient data

Does the radiation approach affects acute toxicity in prostate cancer patients? A comparison of four radiation techniques

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