72 CORRELATION BETWEEN SERUM ANTI CAG A (LgG) AND THE CLINICAL COURSE OF HELICOBACTER PYLORI (HP) INFECTION IN CHILDREN.

Yahav, Jacob; Fradkin, Akiva; Weisselberg, Batia; Diver-Haber, A.; Jones, Abigail

doi:10.1097/00005176-199605000-00085

Cited by 8 publications

(8 citation statements)

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“…IgG antibodies against CagA protein were tested with immunoblot staining using a Western blot kit (Helicoblot 2.0; Genelabs Diagnostic, Singapore). The determinations of CagA seropositivity were in accordance with the manufacturer's criteria [18,19].…”

Section: Serologymentioning

confidence: 99%

Helicobacter pyloriinfection is associated with advanced colorectal neoplasia

Shmuely

Melzer

Braverman

et al. 2013

Scandinavian Journal of Gastroenterology

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Section: Serologymentioning

confidence: 99%

Helicobacter pyloriinfection is associated with advanced colorectal neoplasia

Shmuely

Melzer

Braverman

et al. 2013

Scandinavian Journal of Gastroenterology

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“…Association of the severity of H. pylori induced diseases with virulence entity of the colonized strains was reported in several studies. CagA, VacA, IceA, DupA and urease are among the most important virulence factors whose involvement in the progression of these diseases has been established (Rathbone and Rathbone, 2011 (Kusters et al, 2006;Yahav et al, 2000). Urease of H. pylori accounts for about 10% of the total cell protein that is expressed in most of the strains (Suzuki et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Relationship between ureB Sequence Diversity, Urease Activity and Genotypic Variations of Different Helicobacter pylori Strains in Patients with Gastric Disorders

Ghalehnoei

Ahmadzadeh

Farzi

et al. 2016

Polish Journal of Microbiology

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A b s t r a c tAssociation of the severity of Helicobacter pylori induced diseases with virulence entity of the colonized strains was proven in some studies. Urease has been demonstrated as a potent virulence factor for H. pylori. The main aim of this study was investigation of the relationships of ureB sequence diversity, urease activity and virulence genotypes of different H. pylori strains with histopathological changes of gastric tissue in infected patients suffering from different gastric disorders. Analysis of the virulence genotypes in the isolated strains indicated significant associations between the presence of severe active gastritis and cagA + (P = 0.039) or cagA/iceA1 genotypes (P = 0.026), and intestinal metaplasia and vacA m1 (P = 0.008) or vacA s1/m2 (P = 0.001) genotypes. Our results showed a 2.4-fold increased risk of peptic ulcer (95% CI: 0.483-11.93), compared with gastritis, in the infected patients who had dupA positive strains; however this association was not statistically significant. The results of urease activity showed a significant mean difference between the isolated strains from patients with PUD and NUD (P = 0.034). This activity was relatively higher among patients with intestinal metaplasia. Also a significant association was found between the lack of cagA and increased urease activity among the isolated strains (P = 0.036). While the greatest sequence variation of ureB was detected in a strain from a patient with intestinal metaplasia, the sole determined amino acid change in UreB sequence (Ala201Thr, 30%), showed no influence on urease activity. In conclusion, the supposed role of H. pylori urease to form peptic ulcer and advancing of intestinal metaplasia was postulated in this study. Higher urease activity in the colonizing H. pylori strains that present specific virulence factors was indicated as a risk factor for promotion of histopathological changes of gastric tissue that advance gastric malignancy. K e y w o r d s: Helicobacter pylori, virulence, factor urease activity, histopathological changes

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“…[2378] H. pylori strains may be divided into at least two subgroups based on the expression or nonexpression of cytotoxin-associated gene A (CagA) and the vacuolating cytotoxin. [910] The CagA has been identified as a possible marker of H. pylori virulence. [1112]…”

Section: Introductionmentioning

confidence: 99%

Frequency of Helicobacter pylori and cytotoxine associated gene A antibodies in patients with cardiac syndrome X

Rasmi

Seyyed-Mohammadzad

2012

Journal of Cardiovascular Disease Research

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Background:Cardiac syndrome X (CSX) is a condition in which patients have the pain of angina despite normal coronary angiogram. Recently, Helicobacter pylori (H. pylori) bacteria has been associated with CSX. However, there is no obvious data about the frequency of its virulent strain (cytotoxine associated gene A: CagA) in patients with CSX. We surveyed the frequency of H. pylori and CagA antibodies in patients with cardiac syndrome X and healthy controls.Materials and Methods:Plasma samples from 100 CSX patients (61 females and 39 males; mean age: 51.8 ± 12.3 years) and 100 healthy controls (61 females and 39 males; mean age: 48.9 ± 6.3 years) were tested for the presence of IgG antibody to H. pylori using enzyme linked immunosorbent assay (ELISA) method. Also, infected patients were determined by the presence of IgG antibody to CagA by ELISA method. Statistical analysis was carried out using chi-square test and independent samples T-test.Results:Ninety two percent (92/100) of patients were anti-H. pylori positive (anti-H. pylori+), while only 56.0% (56/100) of control group were anti-H. pylori+ (P<0.01). However, prevalence of anti-CagA positive (anti- CagA+) in H. pylori infected- CSX patients and control groups were 59.8% (55/92) and 60.7% (34/56), respectively (P>0.05).Conclusion:Thus, due to the high frequency of anti-H. pylori in CSX patients, and the probable causative effect of chronic infection in vascular diseases, it is suggested that H. pylori has a probable role in the pathogenesis of CSX.

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72 CORRELATION BETWEEN SERUM ANTI CAG A (LgG) AND THE CLINICAL COURSE OF HELICOBACTER PYLORI (HP) INFECTION IN CHILDREN.

Cited by 8 publications

References 0 publications

Helicobacter pyloriinfection is associated with advanced colorectal neoplasia

Helicobacter pyloriinfection is associated with advanced colorectal neoplasia

Relationship between ureB Sequence Diversity, Urease Activity and Genotypic Variations of Different Helicobacter pylori Strains in Patients with Gastric Disorders

Frequency of Helicobacter pylori and cytotoxine associated gene A antibodies in patients with cardiac syndrome X

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