7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation

Li, Mingzong; Jin, Wei; Jiang, Chen; Zheng, Chao; Tang, Weidong; You, Tianyan; Lou, Liguang

doi:10.1016/j.bmcl.2009.06.010

Cited by 19 publications

(11 citation statements)

References 18 publications

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“…You et al 46 reported a series of 7-cycloalkylcamptothecin derivatives (53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66). As shown in Table III, many of the compounds exhibited IC 50 values in the low moicromolar-to-nanomolar level and were up to 40-fold more potent than 3, the reference compound.…”

Section: A and B Ring Modified Cpt Derivativesmentioning

confidence: 99%

Perspectives on Biologically Active Camptothecin Derivatives

et al. 2015

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Camptothecins (CPTs) are cytotoxic natural alkaloids that specifically target DNA topoisomerase I. Research on CPTs has undergone a significant evolution from the initial discovery of CPT in the late 1960s through the study of synthetic small molecule derivatives to investigation of macromolecular constructs and formulations. Over the past years, intensive medicinal chemistry efforts have generated numerous CPT derivatives. Three derivatives, topotecan, irinotecan, and belotecan, are currently prescribed as anticancer drugs, and several related compounds are now in clinical trials. Interest in other biological effects, besides anticancer activity, of CPTs is also growing exponentially, as indicated by the large number of publications on the subject during the last decades. Therefore, the main focus of the present review is to provide an ample but condensed overview on various biological activities of CPT derivatives, in addition to continued up-to-date coverage of anticancer effects.

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Section: A and B Ring Modified Cpt Derivativesmentioning

confidence: 99%

Perspectives on Biologically Active Camptothecin Derivatives

et al. 2015

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“…, methyl, ethyl) using the corresponding alkyl bromides, peroxide, and acid under thermal conditions. 38 To demonstrate the advantages of using the currently developed, mild photoredox conditions, secondary and primary alkyltrifluoroborates were selected as reagents for generation of analogues. As displayed in Scheme 6, primary α-alkoxyalkyl subunits could be incorporated, along with secondary alkyl moieties ( 7a , 7b ).…”

Section: Practical Applicationsmentioning

confidence: 99%

Metal-free C–H alkylation of heteroarenes with alkyltrifluoroborates: a general protocol for 1°, 2° and 3° alkylation

2017

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“…MCPT was synthesized in-house according to reported procedures [31]. CPT and HCPT with purities of 99% were purchased from Harbin Foran High-Tech Development Ltd. (Harbin, Heilongjiang, China).…”

Section: Chemicals and Reagentsmentioning

confidence: 99%