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doi:10.1001/archderm.107.4.628

Cited by 7 publications

(1 citation statement)

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“…This raises the possibility that the onset of rashes may depend on a variable interaction of viral infection and exogenous inducing factors; the intervention of exogenous factors seems decisive in triggering the expression of eruptions. In this regard, it is of note that viral exanthems are often accentuated in sun-exposed areas: previous reports have described that photolocalized viral exanthems are observed in viral eruptions such as varicella [14, 15, 16], hepatitis B virus infection [17]and echovirus 9 infection [16]. The photoaccentuated eruption in this patient may provide a plausible explanation why viral infection-associated eruptions develop predominantly in sun-exposed areas.…”

Section: Discussionsupporting

confidence: 52%

Photo-Accentuated Eruption and Vascular Deposits of Immunoglobulin A Associated with Hepatitis A Virus Infection

Kano¹,

Kokaji²,

Shiohara³

2000

Dermatology

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Skin rash associated with hepatitis A virus infection has rarely been reported. We describe a patient with hepatitis A virus infection who presented a rubelliform rash markedly accentuated in sun-exposed areas; direct immunofluorescence studies of the lesion revealed immunoglobulin (Ig) A deposition on the endothelial cells in the upper dermis. Oral rechallenge tests of the previously administered drugs failed to reproduce the eruption. The preferential setting of immune complexes containing IgA at sites of sun exposure and sunlight as a triggering factor might have been responsible for the development of the eruption in this patient. Eruptions associated with hepatitis A virus infections may be more frequent than commonly thought. Because of difficulty to exclude the possibility of drug eruptions, these cases might have been overlooked. In patients with such a disorder, a careful clinical workup such as IgM antibodies for hepatitis A virus at diagnosis and during follow-up is especially recommended.

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Section: Discussionsupporting

confidence: 52%

Photo-Accentuated Eruption and Vascular Deposits of Immunoglobulin A Associated with Hepatitis A Virus Infection

Kano¹,

Kokaji²,

Shiohara³

2000

Dermatology

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Acute Generalized Varicella Zoster in the Setting of Preexisting Generalized Erythema

Egan

O'Reilly

Vanderhooft

et al. 1999

Pediatric Dermatology

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We report a 5-year-old girl who initially had generalized erythema from scarlet fever. Four days later she developed sheets of monomorphous vesicles in the areas of erythema. A Tzanck smear of a vesicle base showed multinucleated giant cells, and viral culture grew varicella zoster virus, confirming a clinical diagnosis of varicella. This case illustrates that, with a background of preexisting erythema, varicella may present in an atypical manner.

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