65 Randomized Trial of High-Frequency Oscillatory Ventilation Versus Conventional Ventilation: A 3 Year Follow-Up

Gallini, Francesca; Maggio, Luca; Cota, Francesco; Serrao, Francesca; Vento, Giovanni; Mercuri, E.; Romagnoli, Costantino

doi:10.1203/00006450-201011001-00065

Cited by 2 publications

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“…Also, scholars have always been concerned about the safety of HFOV. Studies have found that the incidence of chronic lung disease and mortality after the application of HFOV is slightly superior to that of CMV, and there is no significant difference in the occurrence of complications, such as air leakage and brain injury ( 25 , 26 ). Current clinical studies have shown that although exogenous PS can improve pulmonary gas exchange in infants with ARDS, its effect on reducing the mortality rate is uncertain ( 8 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of High-Frequency Oscillatory Ventilation Combined With Pulmonary Surfactant in the Treatment of Acute Respiratory Distress Syndrome After Cardiac Surgery: A Prospective Randomised Controlled Trial

Zheng

Lei

Liu

et al. 2021

Front. Cardiovasc. Med.

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Background: This study aimed to evaluate the effects of pulmonary surfactant (PS) combined with high-frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) in infants with acute respiratory distress syndrome (ARDS) after congenital cardiac surgery.Methods: A total of 61 infants with ARDS were eligible and were randomised to the CMV + PS group (n = 30) or the HFOV + PS group (n = 31) between January 2020 and December 2020. The primary outcomes were the changes in arterial blood gas parameters. The duration of mechanical ventilation, length of hospitalisation and the incidence of complications were considered secondary outcomes.Results: A total of 61 infants completed the study. In the HFOV + PS group, the blood gas analysis results were significantly improved (P < 0.05), while the duration of mechanical ventilation and length of hospitalisation were shorter than the CMV + PS group (P < 0.05). However, the incidence of complications was not different between the two groups (P > 0.05).Conclusions: Compared with the CMV + PS group, the HFOV + PS group showed significantly improved ABG variables and had a shortened length of hospitalisation and mechanical ventilation in infants with ARDS after cardiac surgery.Clinical Trial Registration: Chinese Clinical Trial Registry; Number: ChiCTR2000039457.

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Section: Discussionmentioning

confidence: 99%

Effect of High-Frequency Oscillatory Ventilation Combined With Pulmonary Surfactant in the Treatment of Acute Respiratory Distress Syndrome After Cardiac Surgery: A Prospective Randomised Controlled Trial

Zheng

Lei

Liu

et al. 2021

Front. Cardiovasc. Med.

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show abstract

“…The safety of HFOV has always been a concern by scholars. Studies have found that the incidence of chronic lung disease and mortality after the application of HFOV is slightly superior to that of CMV, and there is no signi cant difference in the occurrence of complications such as air leakage and brain injury 24,25 . Current clinical studies have shown that although exogenous PS can improve pulmonary gas exchange in infants with ARDS, its effect on reducing the mortality rate is uncertain 26 .…”

Section: Discussionmentioning

confidence: 99%

Effect of high frequency oscillatory ventilation combined with pulmonary surfactant in the treatment of acute respiratory distress syndrome after cardiac surgery: a prospective randomized controlled trail

Zheng

Lei

Liu

et al. 2021

Preprint

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Objective: This study aimed to evaluate the effects of pulmonary surfactant (PS) combined with high-frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) in infants with acute respiratory distress syndrome (ARDS) after congenital cardiac surgery.Method: A total of 61 infants with ARDS were eligible and were randomized to the CMV + PS group (n= 30) or the HFOV + PS group (n= 31) between January 2020 and December 2020. The primary outcomes were the improvement of the arterial blood gas analysis. The incidence of mechanical ventilation duration, length of hospitalization, and the incidence of complications were considered as secondary outcomes.Results: A total of 61 infants completed the study. In HFOV + PS group, the blood gas analysis results were significantly improved (P<0.05), while, duration of mechanical ventilation and length of hospitalization were shorter than CMV + PS group (P<0.05). But the incidences of complications had no statistical significance between the two groups (P>0.05).Conclusions: Compared with the CMV + PS group, HFOV + PS significantly improved the ABG variables and shortened the length of hospitalization and mechanical ventilation in infants with ARDS after cardiac surgery.

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65 Randomized Trial of High-Frequency Oscillatory Ventilation Versus Conventional Ventilation: A 3 Year Follow-Up

Cited by 2 publications

References 0 publications

Effect of High-Frequency Oscillatory Ventilation Combined With Pulmonary Surfactant in the Treatment of Acute Respiratory Distress Syndrome After Cardiac Surgery: A Prospective Randomised Controlled Trial

Effect of High-Frequency Oscillatory Ventilation Combined With Pulmonary Surfactant in the Treatment of Acute Respiratory Distress Syndrome After Cardiac Surgery: A Prospective Randomised Controlled Trial

Effect of high frequency oscillatory ventilation combined with pulmonary surfactant in the treatment of acute respiratory distress syndrome after cardiac surgery: a prospective randomized controlled trail

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