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Hepatic-targeting microcapsules construction by self-assembly of bioactive galactose-branched polyelectrolyte for controlled drug release system

“…Vinyl hexanedioyl galactose ester monomer was regioselectively synthesized through the transesterification of galactose with divinyl adipate catalyzed by alkaline protease from Bacillus subtilis in pyridine at 50 • C [35]. Poly(vinyl galactose ester-co-methacryloxyethyl trimethylammonium chloride) (PGEDMC, M w = 54,200, M w /M n = 2.4, GPC data) was prepared by copolymerization of vinyl hexanedioyl galactose ester with quaternary ammonium salt using redox initiator in H 2 O.…”

Regiospecific alkaline protease-catalyzed divinyl acyl transesterifications of primary hydroxyl groups of mono- and di-saccharides in pyridine

“…They proved very useful acyl donors for synthesis of polymerizable sugar vinyl esters. [10][11][12] One vinyl ester group of a divinyl dicarboxylate could be used in transesterification reactions and the other as a polymerizable group. The polymer obtained has sugar branches and a poly(vinyl alcohol) main chain, and was shown to be a biodegradable polymer.…”

“…The polymer obtained has sugar branches and a poly(vinyl alcohol) main chain, and was shown to be a biodegradable polymer. 13 To the best of our knowledge, most of the research performed in this area have been devoted to the synthesis of vinyl fatty acid esters of glucose, [11][12][13][14] whereas di-saccharides or other monosaccharides had rarely been studied.…”

Chemo-enzymatic synthesis route to poly(glucosyl-acrylates) using glucosidase from almonds

“…12 Especially enzymes from the class of hydrolases (EC 3) 13 have been widely used in organic synthesis since they are found to catalyze the reverse reaction of hydrolysis, the formation of ester, amide, and glycosidic bonds, under specific conditions. 14 Lipases, [15][16][17][18] proteases [19][20][21] and glycosidases [22][23][24] have mainly been used to prepare saccharide containing monomers including saccharide-acrylates. Lipase and protease catalyzed synthesis of saccharide acrylates is usually done by transesterification of activated esters.…”