6. Ovarian Tissue Cryopreservation Is a Feasible and Safe Procedure in a Pediatric, Adolescent and Young Adult Population for Fertility Preservation Prior to Gonadotoxic Treatment

Streich-Tilles, Tara; Cizek, Stephanie; Burns, Karen; Ferrara, Brycen; Schafer-Kalkhoff, Tara; Frias, Olivia; Breech, Lesley; Rios, Julie Sroga

doi:10.1016/j.jpag.2019.02.108

Cited by 2 publications

(2 citation statements)

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“…However, in some cases, the ovarian dysfunction could become unreversible, leading to POI [ 35 ]. For this reason, in the case of RT or alkylating agents, a strict follow-up and an oncofertility management (i.e., ovarian cryopreservation) is crucial to avoid future reproductive issues [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Anti-Müllerian Hormone Levels and Risk of Premature Ovarian Insufficiency in Female Childhood Cancer Survivors: Systematic Review and Network Meta-Analysis

Torella

Riemma

Franciscis

et al. 2021

Cancers

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Background: Female childhood cancer survivors (CCS) might have impaired ovarian reserves, especially after alkylating agents or radiotherapy. The purpose of this systematic review and network meta-analysis is to evaluate the role of serum anti-Müllerian hormone (AMH) for ovarian reserve screening and the risk of premature ovarian insufficiency (POI) according to the subtype of childhood cancer. (2) Methods: PRISMA-NMA guidelines were followed. We carried out a network meta-analysis based on a random effects model for mixed multiple treatment comparisons to rank childhood cancers effects on fertility by surface under the cumulative ranking curve (SUCRA). Studies were selected only if they had an age-matched control group. Quality assessment was performed using Newcastle–Ottawa Scale. The co-primary outcomes were mean AMH levels and the incidence of POI. (3) Results: A total of 8 studies (1303 participants) were included. Women treated for a neuroblastoma during infancy were more likely to be ranked first for impaired AMH levels (SUCRA = 65.4%), followed by mixed CCS (SUCRA = 29.6%). The greatest rates of POI were found in neuroblastoma survivors (SUCRA = 42.5%), followed by acute lymphoid leukemia (SUCRA = 26.3%) or any other neoplasia (SUCR A = 20.5%). (4) Conclusions: AMH represents a trustworthy approach for ovarian reserve screening. Direct and indirect comparisons found no differences in mean AMH levels and POI risk between subtypes of CCS and healthy controls. SUCRA analysis showed that female neuroblastoma survivors were more at risk for reduced serum AMH levels and increased risk of POI.

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Section: Discussionmentioning

confidence: 99%

Serum Anti-Müllerian Hormone Levels and Risk of Premature Ovarian Insufficiency in Female Childhood Cancer Survivors: Systematic Review and Network Meta-Analysis

Torella

Riemma

Franciscis

et al. 2021

Cancers

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“…Unfortunately, in some cases, this event is not reversible, and POI occurs, making it impossible to get pregnant. Here, the necessity of interventions, such as ovarian cryopreservation, to avoid reproductive issues is highlighted [ 15 ]. The authors of this review also analyzed the correlation between long-term reproductive sequelae experienced by female CCS and the type of cancer (i.e., thyroid cancer, neuroblastoma), describing the same necessity to follow-up patients during and after anticancer therapy administration for all different kinds of cancer.…”

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confidence: 99%