6 Anticonvulsant Drugs

Antiepileptic Drug Development: II. Anticonvulsant Drug Screening

“…Over the succeeding 10 years, a number of authors reported their experience with batteries of screening tests (Sorel, 1957: Bastian, 1961Spinks and Waring, 1962;Everett, 1964: Swinyard, 1969). Despite differences among the reports, all pointed out certain factors common to the screening of potential anticonvulsant drugs.…”

Antiepileptic Drug Development: II. Anticonvulsant Drug Screening

“…Over the succeeding 10 years, a number of authors reported their experience with batteries of screening tests (Sorel, 1957: Bastian, 1961Spinks and Waring, 1962;Everett, 1964: Swinyard, 1969). Despite differences among the reports, all pointed out certain factors common to the screening of potential anticonvulsant drugs.…”

Primidone intoxication in a child.

“…Since primidone is bound to serum proteins less than phenobarbitone (Spinks and Waring, 1963), the use of forced diuresis should be even more effective in the immediate treatment of severe primidone intoxication than in severe phenobarbitone intoxication. In addition, haemodialysis with or without exchange transfusion could probably Summary A case report is presented of a 24-year-old epileptic girl who accidentally ingested 4-5 g. primidone (approximately 400 mg./kg.).…”

Concepts in Biochemical Pharmacology

“…Phenylethylmalondiamide possesses, however, only one-fortieth of the anticonvulsant activity of primidone (SPINKS and WARING, 1963). Phenylethylmalondiamide possesses, however, only one-fortieth of the anticonvulsant activity of primidone (SPINKS and WARING, 1963).…”

Antiepileptic Drug Development: II. Anticonvulsant Drug Screening

“…Over the succeeding 10 years, a number of authors reported their experience with batteries of screening tests (Sorel, 1957: Bastian, 1961Spinks and Waring, 1962;Everett, 1964: Swinyard, 1969). Despite differences among the reports, all pointed out certain factors common to the screening of potential anticonvulsant drugs.…”

Primidone intoxication in a child.

“…Since primidone is bound to serum proteins less than phenobarbitone (Spinks and Waring, 1963), the use of forced diuresis should be even more effective in the immediate treatment of severe primidone intoxication than in severe phenobarbitone intoxication. In addition, haemodialysis with or without exchange transfusion could probably Summary A case report is presented of a 24-year-old epileptic girl who accidentally ingested 4-5 g. primidone (approximately 400 mg./kg.).…”

Concepts in Biochemical Pharmacology

“…Phenylethylmalondiamide possesses, however, only one-fortieth of the anticonvulsant activity of primidone (SPINKS and WARING, 1963). Phenylethylmalondiamide possesses, however, only one-fortieth of the anticonvulsant activity of primidone (SPINKS and WARING, 1963).…”

Antiepileptic Drug Development: II. Anticonvulsant Drug Screening

“…Over the succeeding 10 years, a number of authors reported their experience with batteries of screening tests (Sorel, 1957: Bastian, 1961Spinks and Waring, 1962;Everett, 1964: Swinyard, 1969). Despite differences among the reports, all pointed out certain factors common to the screening of potential anticonvulsant drugs.…”

Primidone intoxication in a child.

“…Since primidone is bound to serum proteins less than phenobarbitone (Spinks and Waring, 1963), the use of forced diuresis should be even more effective in the immediate treatment of severe primidone intoxication than in severe phenobarbitone intoxication. In addition, haemodialysis with or without exchange transfusion could probably Summary A case report is presented of a 24-year-old epileptic girl who accidentally ingested 4-5 g. primidone (approximately 400 mg./kg.).…”

Concepts in Biochemical Pharmacology

“…Phenylethylmalondiamide possesses, however, only one-fortieth of the anticonvulsant activity of primidone (SPINKS and WARING, 1963). Phenylethylmalondiamide possesses, however, only one-fortieth of the anticonvulsant activity of primidone (SPINKS and WARING, 1963).…”