“…Pyrido [2,3-d]pyrimidine derivatives possess wide range of physiological properties, which include antiviral [1], antibacterial [2], diuretic, analgesic [3], anticonvulsive [4,5], anti-inflammatory [6], antipyretic [7], cardiotonic [8,9], antitumoral [10], antihistaminic [11], bactericidal [12], bronchiodilator [13], and also act as a cyclin-dependent kinase 4 inhibitor [14]. Pyrido [3,2-d]pyrimidines act as dihydrofolate reductase inhibitors and tyrosine kinase inhibitors [15].…”