5H-Dibenz[b,f]azepine based pyrazole sulphonamides: A privileged platform for probing the antimicrobial and antioxidative properties

Novel Dibenzoazepine-Substituted Triazole Hybrids as Cholinesterase and Carbonic Anhydrase Inhibitors and Anticancer Agents: Synthesis, Characterization, Biological Evaluation, and In Silico Studies

“…Due to their biological and pharmacological activities and structural diversity, these structures have become interesting targets for synthetic chemists. 27 − 29 …”

Novel Dibenzoazepine-Substituted Triazole Hybrids as Cholinesterase and Carbonic Anhydrase Inhibitors and Anticancer Agents: Synthesis, Characterization, Biological Evaluation, and In Silico Studies

“…Due to their biological and pharmacological activities and structural diversity, these structures have become interesting targets for synthetic chemists. 27 − 29 …”

Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis

“…Among the heterocyclic compounds that contain nitrogen and sulfur, sulfonamide derivatives with a pyrazole moiety hold a privileged position in organic chemistry ( Kołaczek et al, 2014 ; Khan et al, 2016 ; Dhameja and Gupta, 2019 ; Faisal et al, 2019 ). They not only act as anticonvulsants ( Abdul-Gafoor, 2016 ; Abdelgawad et al, 2018 ; Mishra et al, 2018 ), anti-stress and anxiogenics ( Channar et al, 2018 ; Saha and Pal, 2020 ), antitumor ( Channar et al, 2018 ), antiviral ( Badampudi et al, 2014 ; Kołaczek et al, 2014 ; Kumar et al, 2015 ; Mustafa et al, 2022 ), antimicrobial, anticholinesterase ( Mumtaz et al, 2019 ; Ghosh et al, 2020 ; Verma et al, 2020), antiulcer ( Khan et al, 2018 ), and antimalarial ( Thillainayagam et al, 2020 ) but also exhibit a variety of enzyme inhibition properties ( Mumtaz et al, 2019 ; Bayrak, 2022 ; Chalkha et al, 2022 ; Mustafa et al, 2022 ). Additionally, some of the pyrazole-containing sulfonamide derivatives have been tested against α -glucosidase ( Shu et al, 2016 ; Azimi et al, 2021 ).…”

“…β -glucosidase is an enzyme that catalyzes the hydrolysis of cellobiose’s glycosidic bonds to produce glucose in the digestive system ( Kumar et al, 2015 ). Similarly, α -glucosidase converts starch and other dietary carbohydrates into glucose ( Joshi et al, 2015 ).…”

“…Similarly, α -glucosidase converts starch and other dietary carbohydrates into glucose ( Joshi et al, 2015 ). After that, the breakdown of carbohydrates releases glucose into the bloodstream, causing hyperglycemia ( Tucci et al, 2010 ; Joshi et al, 2015 ; Kumar et al, 2015 ). Consequently, the inhibition of α - and β -glucosidase enzymes can suppress the digestion of carbohydrates, causing a delay in the absorption of glucose and resulting in decreased blood sugar levels ( Tucci et al, 2010 ; Joshi et al, 2015 ; Kumar et al, 2015 ).…”

“…After that, the breakdown of carbohydrates releases glucose into the bloodstream, causing hyperglycemia ( Tucci et al, 2010 ; Joshi et al, 2015 ; Kumar et al, 2015 ). Consequently, the inhibition of α - and β -glucosidase enzymes can suppress the digestion of carbohydrates, causing a delay in the absorption of glucose and resulting in decreased blood sugar levels ( Tucci et al, 2010 ; Joshi et al, 2015 ; Kumar et al, 2015 ). Nevertheless, drugs like acarbose, voglibose, and miglitol inhibit the glucosidase enzyme, although it is commonly reported that they have undesirable side effects such as diarrhea, abdominal pain, bloating, and flatulence ( Lee et al, 2007 ; Fang et al, 2010 ; Derosa and Maffioli, 2012 ).…”

Novel Dibenzoazepine-Substituted Triazole Hybrids as Cholinesterase and Carbonic Anhydrase Inhibitors and Anticancer Agents: Synthesis, Characterization, Biological Evaluation, and In Silico Studies

“…Due to their biological and pharmacological activities and structural diversity, these structures have become interesting targets for synthetic chemists. 27 − 29 …”

Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis

“…Among the heterocyclic compounds that contain nitrogen and sulfur, sulfonamide derivatives with a pyrazole moiety hold a privileged position in organic chemistry ( Kołaczek et al, 2014 ; Khan et al, 2016 ; Dhameja and Gupta, 2019 ; Faisal et al, 2019 ). They not only act as anticonvulsants ( Abdul-Gafoor, 2016 ; Abdelgawad et al, 2018 ; Mishra et al, 2018 ), anti-stress and anxiogenics ( Channar et al, 2018 ; Saha and Pal, 2020 ), antitumor ( Channar et al, 2018 ), antiviral ( Badampudi et al, 2014 ; Kołaczek et al, 2014 ; Kumar et al, 2015 ; Mustafa et al, 2022 ), antimicrobial, anticholinesterase ( Mumtaz et al, 2019 ; Ghosh et al, 2020 ; Verma et al, 2020), antiulcer ( Khan et al, 2018 ), and antimalarial ( Thillainayagam et al, 2020 ) but also exhibit a variety of enzyme inhibition properties ( Mumtaz et al, 2019 ; Bayrak, 2022 ; Chalkha et al, 2022 ; Mustafa et al, 2022 ). Additionally, some of the pyrazole-containing sulfonamide derivatives have been tested against α -glucosidase ( Shu et al, 2016 ; Azimi et al, 2021 ).…”

“…β -glucosidase is an enzyme that catalyzes the hydrolysis of cellobiose’s glycosidic bonds to produce glucose in the digestive system ( Kumar et al, 2015 ). Similarly, α -glucosidase converts starch and other dietary carbohydrates into glucose ( Joshi et al, 2015 ).…”

“…Similarly, α -glucosidase converts starch and other dietary carbohydrates into glucose ( Joshi et al, 2015 ). After that, the breakdown of carbohydrates releases glucose into the bloodstream, causing hyperglycemia ( Tucci et al, 2010 ; Joshi et al, 2015 ; Kumar et al, 2015 ). Consequently, the inhibition of α - and β -glucosidase enzymes can suppress the digestion of carbohydrates, causing a delay in the absorption of glucose and resulting in decreased blood sugar levels ( Tucci et al, 2010 ; Joshi et al, 2015 ; Kumar et al, 2015 ).…”

“…After that, the breakdown of carbohydrates releases glucose into the bloodstream, causing hyperglycemia ( Tucci et al, 2010 ; Joshi et al, 2015 ; Kumar et al, 2015 ). Consequently, the inhibition of α - and β -glucosidase enzymes can suppress the digestion of carbohydrates, causing a delay in the absorption of glucose and resulting in decreased blood sugar levels ( Tucci et al, 2010 ; Joshi et al, 2015 ; Kumar et al, 2015 ). Nevertheless, drugs like acarbose, voglibose, and miglitol inhibit the glucosidase enzyme, although it is commonly reported that they have undesirable side effects such as diarrhea, abdominal pain, bloating, and flatulence ( Lee et al, 2007 ; Fang et al, 2010 ; Derosa and Maffioli, 2012 ).…”

Novel Dibenzoazepine-Substituted Triazole Hybrids as Cholinesterase and Carbonic Anhydrase Inhibitors and Anticancer Agents: Synthesis, Characterization, Biological Evaluation, and In Silico Studies

“…Due to their biological and pharmacological activities and structural diversity, these structures have become interesting targets for synthetic chemists. 27 − 29 …”

Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis

“…Among the heterocyclic compounds that contain nitrogen and sulfur, sulfonamide derivatives with a pyrazole moiety hold a privileged position in organic chemistry ( Kołaczek et al, 2014 ; Khan et al, 2016 ; Dhameja and Gupta, 2019 ; Faisal et al, 2019 ). They not only act as anticonvulsants ( Abdul-Gafoor, 2016 ; Abdelgawad et al, 2018 ; Mishra et al, 2018 ), anti-stress and anxiogenics ( Channar et al, 2018 ; Saha and Pal, 2020 ), antitumor ( Channar et al, 2018 ), antiviral ( Badampudi et al, 2014 ; Kołaczek et al, 2014 ; Kumar et al, 2015 ; Mustafa et al, 2022 ), antimicrobial, anticholinesterase ( Mumtaz et al, 2019 ; Ghosh et al, 2020 ; Verma et al, 2020), antiulcer ( Khan et al, 2018 ), and antimalarial ( Thillainayagam et al, 2020 ) but also exhibit a variety of enzyme inhibition properties ( Mumtaz et al, 2019 ; Bayrak, 2022 ; Chalkha et al, 2022 ; Mustafa et al, 2022 ). Additionally, some of the pyrazole-containing sulfonamide derivatives have been tested against α -glucosidase ( Shu et al, 2016 ; Azimi et al, 2021 ).…”

“…β -glucosidase is an enzyme that catalyzes the hydrolysis of cellobiose’s glycosidic bonds to produce glucose in the digestive system ( Kumar et al, 2015 ). Similarly, α -glucosidase converts starch and other dietary carbohydrates into glucose ( Joshi et al, 2015 ).…”

“…Similarly, α -glucosidase converts starch and other dietary carbohydrates into glucose ( Joshi et al, 2015 ). After that, the breakdown of carbohydrates releases glucose into the bloodstream, causing hyperglycemia ( Tucci et al, 2010 ; Joshi et al, 2015 ; Kumar et al, 2015 ). Consequently, the inhibition of α - and β -glucosidase enzymes can suppress the digestion of carbohydrates, causing a delay in the absorption of glucose and resulting in decreased blood sugar levels ( Tucci et al, 2010 ; Joshi et al, 2015 ; Kumar et al, 2015 ).…”

“…After that, the breakdown of carbohydrates releases glucose into the bloodstream, causing hyperglycemia ( Tucci et al, 2010 ; Joshi et al, 2015 ; Kumar et al, 2015 ). Consequently, the inhibition of α - and β -glucosidase enzymes can suppress the digestion of carbohydrates, causing a delay in the absorption of glucose and resulting in decreased blood sugar levels ( Tucci et al, 2010 ; Joshi et al, 2015 ; Kumar et al, 2015 ). Nevertheless, drugs like acarbose, voglibose, and miglitol inhibit the glucosidase enzyme, although it is commonly reported that they have undesirable side effects such as diarrhea, abdominal pain, bloating, and flatulence ( Lee et al, 2007 ; Fang et al, 2010 ; Derosa and Maffioli, 2012 ).…”