596 Selenium preserves keratinocyte stemness and delays senescence by maintaining epidermal adhesion

Abstract

Vasculature cross-talking with epithelial stem cells is not understood in adult skin homeostasis. Skin vasculature undergoes dramatic remodeling during adult hair cycle. Specifically, a dermal horizontal plexus transiently neighbors the hair follicle stem cell activation zone during the quiescence phase of hair homeostasis (cycle). We showed that increased density of this plexus was induced by reciprocal mutations in the epithelium (Runx1) and endothelium (Alk1). This increase in vasculature correlates with prolonged quiescence of hair follicle stem cells and delayed entry into the hair growth phase, suggesting an inhibitory role of dense vasculature neighboring stem cells. Suggestively, we find that skin vasculature produces BMP4, a known hair follicle stem cell quiescence-inducing factor. Our work provides a scaffold for understanding how reciprocal cross-talking between epithelial stem cells and their neighboring vasculature promotes coordinated remodeling and modulates timing of hair follicle stem cell activation for proper tissue homeostasis of adult skin.

The Status of Selenium and Zinc in the Urine of Children From Endemic Areas of Kashin-Beck Disease Over Three Consecutive Years

“…It has been demonstrated that selenium deficiency is one of the crucial etiological factors for KBD, and the relevance between Se and KBD relies on a specific relationship between the morbidity of KBD and the content of Se in several samples, such as soil, drinking water, food, and human biological samples (15,16). A previous study found that Se could improve cell aging and strengthen lipid peroxidation (17,18), which played a key role in articular cartilage damage in patients with KBD (19). Moreover, Se supplementation has been suggested to be functional in preventing new cases of KBD in children based on meta-analysis (20).…”