544: Mucus-Degrading Microbiota and Proinflammatory T-Cell Responses Underlie Helicobacter Pylori Induced Colon Carcinogenesis

Ralser, Anna; Dietl, Alisa; Jarosch, Sebastian; Engelsberger, Veronika; Wanisch, Andreas; Janssen, Klaus–Peter; Quante, Michael; Haller, Dirk; Deng, Li; Mejías-Luque, Raquel; Gerhard, Markus

doi:10.1016/s0016-5085(22)60311-1

Cited by 1 publication

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“…The fact that H. pylori infection accelerates colorectal carcinogenesis, and early antibiotic eradication of H. pylori infection reduces the tumor incidence to the level of uninfected controls have been demonstrated before (Ralser et al, 2022).…”

Section: H Pylori-driven Crc Is Characterized By An Altered But Dynam...mentioning

confidence: 99%

“…The epidemiological findings and meta-analysis have implied a close correlation between CRC and H. pylori infection (Kim et al, 2017;Butt and Epplein, 2019;Zuo et al, 2020). To better understand the mechanisms of causal effect of H. pylori on CRC, Ralser et al recently conducted a series of analyses of H. pylori-induced changes in gut environment on Apcmutant mouse models and C57BL/6 mice, and further verified the findings in human samples (Ralser et al, 2022). H. pylori infection was found to cause the deregulation of enteric immunity, and significantly alter the bacterial community structures, characterized by the mucus-degrading microbiota expansion (Ralser et al, 2022).…”

Section: Introductionmentioning

confidence: 96%

“…To better understand the mechanisms of causal effect of H. pylori on CRC, Ralser et al recently conducted a series of analyses of H. pylori-induced changes in gut environment on Apcmutant mouse models and C57BL/6 mice, and further verified the findings in human samples (Ralser et al, 2022). H. pylori infection was found to cause the deregulation of enteric immunity, and significantly alter the bacterial community structures, characterized by the mucus-degrading microbiota expansion (Ralser et al, 2022). In short, the homeostasis in the gut would be disrupted by the H. pylori invasion and contribute to colorectal carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Altered virome structrue and function characterization in Helicobacter pylori-driven colorectal carcinogenesis and H. pylori eradication

Luo

Xue

et al. 2022

Preprint

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The understanding of gut virome and its role in Helicobacter pylori-driven colorectal cancer (CRC), as well as the long-term impact of H. pylori eradication via antibiotic treatment on it could contribute to better understanding the mechanisms of the disruption of gut bacteriome homeostasis involved in H. pylori-driven colorectal carcinogenesis and antibiotic therapy for H. pylori eradication. In the dynamic analysis of viral genome shotgun metagenomic of samples from lower gastrointestinal tract of the Apc+/1638N and C57BL/6 mice with H. pylori infection and eradication, stable viral abundance and replacement of bursted unique viral contigs in infected and uninfected Apc+/1638N mice were observed. Temperate phages, which encoding comprehensive microbial functional genes and targeting various susceptible hosts, were expanded extremely prior to cancer exacerbation. In addition, short-term antibiotic exposure for H. pylori eradication was able to alter the gut virome and thrive the antibiotic resistance genes (ARGs) in the viral genome for at least 6 months. Collectively, these results point toward a potential role of the altered, but dynamically balanced gut virome, characterized by the expanded temperate phages, in contributing to the H. pylori-driven CRC, and indicate that viral genome may act as ARG reservoir for the antibiotic resistance of bacteria after the antibiotics therapy to H. pylori eradication.

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Section: H Pylori-driven Crc Is Characterized By An Altered But Dynam...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Altered virome structrue and function characterization in Helicobacter pylori-driven colorectal carcinogenesis and H. pylori eradication

Luo

Xue

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

544: Mucus-Degrading Microbiota and Proinflammatory T-Cell Responses Underlie Helicobacter Pylori Induced Colon Carcinogenesis

Cited by 1 publication

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Altered virome structrue and function characterization in Helicobacter pylori-driven colorectal carcinogenesis and H. pylori eradication

Altered virome structrue and function characterization in Helicobacter pylori-driven colorectal carcinogenesis and H. pylori eradication

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