535 Safety and Efficacy of Entecavir in Patients Receiving Liver Transplant Due to Chronic Hepatitis B

High Genetic Barrier Nucleos(t)ide Analogue(s) for Prophylaxis From Hepatitis B Virus Recurrence After Liver Transplantation: A Systematic Review

“…In total, 94 articles were initially identified from the literature search, but only 20 studies (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) fulfilled the inclusion criteria ( Figure A1). Of two studies (14,15) from one center in China with overlapping study periods, only the latest one (14) was included in the analysis.…”

“…Six studies were from USA (8,10,12,18,19,21), three from China (7,14,20), two from Spain (13,16), two from Japan (9,25) and one study from Netherlands (17), India (23), Taiwan (22) and Greece (11). Eleven studies evaluated the combination of HBIG with hgbNA(s) (7,9,10,(12)(13)(14)16,18,19,22,25), while eight studies (8,11,(17)(18)(19)(20)(21)23) evaluated patients under hgbNA(s) after HBIG discontinuation or without any HBIG (Figure 1). There was only one randomized controlled trial (10), while seven were prospective cohort (7,11,12,17,18,21,23) and nine retrospective cohort studies (8,9,13,14,16,19,…”

“…Eleven studies evaluated the combination of HBIG with hgbNA(s) (7,9,10,(12)(13)(14)16,18,19,22,25), while eight studies (8,11,(17)(18)(19)(20)(21)23) evaluated patients under hgbNA(s) after HBIG discontinuation or without any HBIG (Figure 1). There was only one randomized controlled trial (10), while seven were prospective cohort (7,11,12,17,18,21,23) and nine retrospective cohort studies (8,9,13,14,16,19,20,22,25).…”

“…In particular, monotherapy with LAM was used in 1910 (86%) (12, and with a hgbNA(s) in 304 (14%) patients (7,9,10,12,14,16,18,19,22,25) (Table 1). Patients who received HBIG and a hgbNA with or without another NA were considered as patients treated with HBIG and a hgbNA and were analyzed together, unless otherwise stated.…”

“…Details regarding the mode of HBIG administration were available in 131 patients included in all but four studies (10,12,18,22): 31 of them received HBIG always intravenously (IV), 97 always intramuscularly (IM) and 3 IV for the first period after LT and IM thereafter.…”