511: Inflammatory cytokines and spontaneous preterm birth in asymptomatic women: a systematic review

Wei, Shu Qin; Yang, Fulun; Fraser, William D.; Luo, Zhong‐Cheng

doi:10.1016/j.ajog.2009.10.677

Cited by 83 publications

(101 citation statements)

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“…Inflammatory cytokines are thought to play an important role in preterm delivery pathogenesis with infection occurring via the uterine cervix (17,18).…”

Section: Discussionmentioning

confidence: 99%

Influence of lactoferrin in preventing preterm delivery: A pilot study

Giunta¹,

Giuffrida²,

Mangano

et al. 2011

Mol Med Report

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“…Inflammatory cytokines are thought to play an important role in preterm delivery pathogenesis with infection occurring via the uterine cervix (17,18).…”

Section: Discussionmentioning

confidence: 99%

Influence of lactoferrin in preventing preterm delivery: A pilot study

Giunta¹,

Giuffrida²,

Mangano

et al. 2011

Mol Med Report

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“…It is possible that actions of NO or glutathione may accumulate as a consequence of vascular NO generation and redox reactions in uterine myocytes that then manage contractile force. The notion that pregnancy physiology and preterm birth may in part involve an infl ammatory-like state [41] fi ts with this notion and provides a testable platform for these ideas.…”

Section: No-mediated Relaxationmentioning

confidence: 99%

A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction

Buxton

Heyman

et al. 2011

Acta Pharmacol Sin

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Rates of premature birth are alarming and threaten societies and healthcare systems worldwide. Premature labor results in premature birth in over 50% of cases. Preterm birth accounts for three-quarters of infant morbidity and mortality. Children that survive birth before 34 weeks gestation often face life-long disability. Current treatments for preterm labor are wanting. No treatment has been found to be generally effective and none are systematically evaluated beyond 48 h. New approaches to the treatment of preterm labor are desperately needed. Recent studies from our laboratory suggest that the uterine muscle is a unique compartment with regulation of uterine relaxation unlike that of other smooth muscles. Here we discuss recent evidence that the mechanically activated 2-pore potassium channel, TREK-1, may contribute to contraction-relaxation signaling in uterine smooth muscle and that TREK-1 gene variants associated with human labor and preterm labor may lead to a better understanding of preterm labor and its possible prevention.

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“…While moderate inflammation may be beneficial to pregnancy, excessive production of pro-inflammatory cytokines is harmful and contributes to adverse pregnancy outcomes, such as miscarriage, preterm birth (PTB) and preeclampsia (PE) (Redman and Sargent, 2004, Wei et al, 2010, Calleja-Agius et al, 2012. During placentation fetal trophoblasts form the growing placenta and invade the maternal uterine wall, interacting with maternal cells and modifying the uterine vasculature.…”

Section: Introductionmentioning

confidence: 99%