2005
DOI: 10.1007/s00280-004-0967-y View full text |Buy / Rent full text
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Abstract: The excellent pharmacokinetic properties of PTAU, and its extraordinary effectiveness in improving the oral bioavailability of uridine, could be useful to rescue or protect from host toxicities of 5-fluorouracil and various chemotherapeutic pyrimidine analogues used in the treatment of cancer and AIDS, as well as in the management of medical disorders that are remedied by the administration of uridine including CNS disorders (e.g. Huntington's disease, bipolar disorder), liver diseases, diabetic neuropathy, ca… Show more

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“…In addition, numerous pyrimidine-related derivatives displayed marked activities against herpes simplex viruses (HSV) [8], and hepatitis B viruses (HBV) [9]. Moreover, potent anticancer [10,11] and antimicrobial activities [12][13][14][15] were observed among several pyrimidine-2,4-dione derivatives. In the present investigation, we report the crystal structure of the title compound, which was proved to exhibit marked anti-HIV-1 activity [7].…”
Section: Discussionmentioning
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“…In addition, numerous pyrimidine-related derivatives displayed marked activities against herpes simplex viruses (HSV) [8], and hepatitis B viruses (HBV) [9]. Moreover, potent anticancer [10,11] and antimicrobial activities [12][13][14][15] were observed among several pyrimidine-2,4-dione derivatives. In the present investigation, we report the crystal structure of the title compound, which was proved to exhibit marked anti-HIV-1 activity [7].…”
Section: Discussionmentioning
“…Pyrimidine-2,4-diones and their related derivatives have long been known for their diverse chemotherapeutic activities including antiviral activity against HIV [1][2][3][4][5] and HSV viruses [6]. In addition, potent anticancer [7][8][9][10] and antimicrobial activities [11,12] was observed for several pyrimidine-2,4-diones. In continuation to our interest in the chemical and pharmacological properties of pyrimidine and uracil derivatives [13][14][15][16] we synthesized the title compound as potential chemotherapeutic agent.…”
Section: Discussionmentioning
“…The chemotherapeutic e cacy of pyrimidine derivatives is related to their ability to inhibit vital enzymes responsible for DNA biosynthesis as dihydrofolate reductase (DHFR), thymidylate synthetase (TSase), thymidine phosphorylase (TPase) and reverse transcriptase (RTase). Non-nucleoside pyrimidine-based derivatives have long been known as potent anticancer drugs [1][2][3][4]. Large array of pyrimidine-based analogues have emerged as useful therapies against human immunode ciency viruses (HIV) [5][6][7][8], hepatitis B viruses (HBV) [9], herpes simplex viruses (HSV) [10,11], in uenza viruses [12] and varicella-zoster virus (VZV) [13].…”
Section: Discussionmentioning