5% Imiquimod Cream for the Treatment of Large Superficial Basal Cell Carcinoma

Overall treatment success after treatment of primary superficial basal cell carcinoma: a systematic review and meta-analysis of randomized and nonrandomized trials

“…Second, we pooled the results of five imiquimod studies with a dosing regimen of 5 days per week during 6 weeks 22,27,40,42,47 . A similar pooled estimate for the proportion with a complete response of 85·8% (95% CI 79–93%, I 2 = 82%, P < 0·0001) was found compared with 86·2% (95% CI 82–90%) for all imiquimod studies.…”

“…45 The majority of studies provided data on the results of treatment with PDT (16) 11,[30][31][32][33][34]43,45,46,[48][49][50][52][53][54][55] or imiquimod (15). [21][22][23][24][27][28][29][35][36][37]40,42,44,45,47 Other treatments that were evaluated were pulsed dye laser, 38,39,51 5-fluorouracil (5-FU), 25,41 cryotherapy, 30,33 surgical excision 31 and PEP005. 26 The latter is also known as ingenol mebutate.…”

“…Probabilities of complete response after treatment could be derived from 34 of 36 studies, 11,[21][22][23][24][25][26][27][28][29][30][31][32][34][35][36][37][38][39][40][41][42][44][45][46][47][48][49][50][51][52][53][54][55] and information on recurrence probabilities during follow-up was available in 23 of 36 studies. 11,21,[30][31][32][33][34][35][36][37]39,40,[42][43][44][45][46]…”

“…An additional histopathological verification was performed in 18 of 34 studies that reported residue probabilities, of which most were studies on imiquimod. [22][23][24][25][26][27][28][29]37,38,41,42,45,47,48,[51][52][53] From the 23 studies that reported recurrence probabilities, two studies performed an additional histopathological verification of the diagnosis. 33,44 Probability of complete response after treatment with imiquimod or photodynamic therapy Probabilities of complete response after treatment with imiquimod could be derived from 15 studies with a total of 1088 sBCCs.…”

“…33,44 Probability of complete response after treatment with imiquimod or photodynamic therapy Probabilities of complete response after treatment with imiquimod could be derived from 15 studies with a total of 1088 sBCCs. [21][22][23][24][27][28][29][35][36][37]40,42,44,45,47 From six dose-finding studies, data were used from only one study arm. [21][22][23][24]27,28 The preferred arm had a dosing regimen most similar to the widely used protocol of imiquimod dosed 5 days a week for 6 weeks.…”