5-HT1A receptor responsivity in anxiety disorders and depression

Serotonin-1A receptor imaging in recurrent depression: replication and literature review

“…These data were compatible with the results of 5-HT 1A R agonist challenge studies, which showed that unmedicated MDD subjects have blunted hypothermic and adrenocorticotropin (ACTH) and cortisol release relative to controls in response to ipsapirone or buspirone [43][44][45]. Since 5-HT 1A R stimulation induced hypothermia and ACTH/cortisol release are thought to distinguish pre-and postsynaptic 5-HT 1A R stimulation, respectively, in humans and rats, 47 these findings were compatible with the PET data implicating both pre-and postsynaptic 5-HT 1A R in MDD.…”

Serotonin-1A receptor imaging in recurrent depression: replication and literature review

“…These data were compatible with the results of 5-HT 1A R agonist challenge studies, which showed that unmedicated MDD subjects have blunted hypothermic and adrenocorticotropin (ACTH) and cortisol release relative to controls in response to ipsapirone or buspirone [43][44][45]. Since 5-HT 1A R stimulation induced hypothermia and ACTH/cortisol release are thought to distinguish pre-and postsynaptic 5-HT 1A R stimulation, respectively, in humans and rats, 47 these findings were compatible with the PET data implicating both pre-and postsynaptic 5-HT 1A R in MDD.…”

Decreased sensitivity of 5-HT1D receptors in melancholic depression

“…Our data suggest that patients with melancholic depression have blunted growth hormone responses to zolmitriptan. In this respect our findings are similar to those of challenge studies using 5-HT 1A receptor ligands, where blunted endocrine and thermic responses are particularly apparent in subjects with melancholic depression (Lesch, 1992; Cowen et al , 1994). Two other studies have reported blunted growth hormone responses to sumatriptan in patients with major depression (Yatham et al , 1997; Cleare et al , 1998), although results of sumatriptan challenge are difficult to interpret because of the number of healthy subjects who fail to produce useful growth hormone responses.…”

Involvement of 5-HT 1A Receptors in Animal Tests of Anxiety and Depression: Evidence from Genetic Models

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Serotonin-1A receptor imaging in recurrent depression: replication and literature review

“…These data were compatible with the results of 5-HT 1A R agonist challenge studies, which showed that unmedicated MDD subjects have blunted hypothermic and adrenocorticotropin (ACTH) and cortisol release relative to controls in response to ipsapirone or buspirone [43][44][45]. Since 5-HT 1A R stimulation induced hypothermia and ACTH/cortisol release are thought to distinguish pre-and postsynaptic 5-HT 1A R stimulation, respectively, in humans and rats, 47 these findings were compatible with the PET data implicating both pre-and postsynaptic 5-HT 1A R in MDD.…”

Decreased sensitivity of 5-HT1D receptors in melancholic depression

“…Our data suggest that patients with melancholic depression have blunted growth hormone responses to zolmitriptan. In this respect our findings are similar to those of challenge studies using 5-HT 1A receptor ligands, where blunted endocrine and thermic responses are particularly apparent in subjects with melancholic depression (Lesch, 1992; Cowen et al , 1994). Two other studies have reported blunted growth hormone responses to sumatriptan in patients with major depression (Yatham et al , 1997; Cleare et al , 1998), although results of sumatriptan challenge are difficult to interpret because of the number of healthy subjects who fail to produce useful growth hormone responses.…”

Involvement of 5-HT 1A Receptors in Animal Tests of Anxiety and Depression: Evidence from Genetic Models

“……”

Serotonin-1A receptor imaging in recurrent depression: replication and literature review

“…These data were compatible with the results of 5-HT 1A R agonist challenge studies, which showed that unmedicated MDD subjects have blunted hypothermic and adrenocorticotropin (ACTH) and cortisol release relative to controls in response to ipsapirone or buspirone [43][44][45]. Since 5-HT 1A R stimulation induced hypothermia and ACTH/cortisol release are thought to distinguish pre-and postsynaptic 5-HT 1A R stimulation, respectively, in humans and rats, 47 these findings were compatible with the PET data implicating both pre-and postsynaptic 5-HT 1A R in MDD.…”

Decreased sensitivity of 5-HT1D receptors in melancholic depression

“…Our data suggest that patients with melancholic depression have blunted growth hormone responses to zolmitriptan. In this respect our findings are similar to those of challenge studies using 5-HT 1A receptor ligands, where blunted endocrine and thermic responses are particularly apparent in subjects with melancholic depression (Lesch, 1992; Cowen et al , 1994). Two other studies have reported blunted growth hormone responses to sumatriptan in patients with major depression (Yatham et al , 1997; Cleare et al , 1998), although results of sumatriptan challenge are difficult to interpret because of the number of healthy subjects who fail to produce useful growth hormone responses.…”

Involvement of 5-HT 1A Receptors in Animal Tests of Anxiety and Depression: Evidence from Genetic Models

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