5-fluorouracil plus tauromustine in advanced colorectal cancer: Unexpected negative results

Pharmacokinetic Drug Interactions with Anticancer Drugs

“…After publication of unexpectedly negative clinical results following administration of fluorouracil in combination with tauromustine (TCNU) [Taal et al 1990], we found sequence-dependent antitumour activity and toxicity associated with this drug combination in mice (Hill & Bibby 1994a;Hill et al 1992). Effects ranged from antagonism when fluorouracil was given 24 hours before tauromustine, to additive when the drugs were given simultaneously, and to synergism when fluorouracil was given 24 hours after tauromustine.…”

Pharmacokinetic Drug Interactions with Anticancer Drugs

“…After publication of unexpectedly negative clinical results following administration of fluorouracil in combination with tauromustine (TCNU) [Taal et al 1990], we found sequence-dependent antitumour activity and toxicity associated with this drug combination in mice (Hill & Bibby 1994a;Hill et al 1992). Effects ranged from antagonism when fluorouracil was given 24 hours before tauromustine, to additive when the drugs were given simultaneously, and to synergism when fluorouracil was given 24 hours after tauromustine.…”

Pharmacokinetic Drug Interactions with Anticancer Drugs

“…After publication of unexpectedly negative clinical results following administration of fluorouracil in combination with tauromustine (TCNU) [Taal et al 1990], we found sequence-dependent antitumour activity and toxicity associated with this drug combination in mice (Hill & Bibby 1994a;Hill et al 1992). Effects ranged from antagonism when fluorouracil was given 24 hours before tauromustine, to additive when the drugs were given simultaneously, and to synergism when fluorouracil was given 24 hours after tauromustine.…”

Pharmacokinetic Drug Interactions with Anticancer Drugs

“…After publication of unexpectedly negative clinical results following administration of fluorouracil in combination with tauromustine (TCNU) [Taal et al 1990], we found sequence-dependent antitumour activity and toxicity associated with this drug combination in mice (Hill & Bibby 1994a;Hill et al 1992). Effects ranged from antagonism when fluorouracil was given 24 hours before tauromustine, to additive when the drugs were given simultaneously, and to synergism when fluorouracil was given 24 hours after tauromustine.…”